1240783-02-1

Basic information

• Product Name: 5-Bromo-2-pyrimidinemethanamine
• Synonyms: 5-Bromo-2-pyrimidinemethanamine;(5-broMopyriMidin-2-yl)MethanaMine;(5-Bromopyrimidin-2-yl);2-aminomethyl-5-bromopyrimidine
• CAS NO: 1240783-02-1
• Molecular Formula: C5H6BrN3
• Molecular Weight: 188
• Mol File: 1240783-02-1.mol

Chemical Properties

• Boiling Point: 245℃
• Flash Point: 102℃
• Appearance: /
• Density: 1.678
• PKA: 7.22±0.29(Predicted)
• CAS DataBase Reference: 5-Bromo-2-pyrimidinemethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-pyrimidinemethanamine(1240783-02-1)
• EPA Substance Registry System: 5-Bromo-2-pyrimidinemethanamine(1240783-02-1)

Safety Data

• Hazardous Substances Data: 1240783-02-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
5-Bromo-2-pyrimidinemethanamine is utilized as a key intermediate in the synthesis of various organic compounds. Its chemical properties make it a versatile building block for the creation of pharmaceuticals with potential therapeutic benefits.
Used in Chemical Research:
In the realm of chemical research, 5-Bromo-2-pyrimidinemethanamine serves as a valuable compound for exploring novel chemical reactions and transformations. Its unique structure allows for the investigation of new pathways and mechanisms in organic chemistry.
Used in Drug Synthesis:
5-Bromo-2-pyrimidinemethanamine is employed as a precursor in the production of valuable chemicals and pharmaceuticals. Its presence in the molecular structure can influence the pharmacological properties of the final product, making it an important component in drug discovery and development.
Used in Chemical Process Development:
5-Bromo-2-pyrimidinemethanamine is also used in the development of new chemical processes, where its reactivity and the presence of the bromine atom can be leveraged to improve the efficiency and selectivity of chemical reactions.
Overall, 5-Bromo-2-pyrimidinemethanamine is a promising chemical entity with applications spanning across various industries, including pharmaceuticals, where its potential to contribute to the advancement of new therapeutic agents is recognized.

Upstream product

• 7752-78-5 5-bromo-2-methylpyrimidine 
• 100707-39-9 5-bromo-2-methyl-pyrimidine-4-carboxylic acid 
• 1193116-74-3 5-bromo-2-(bromomethyl)pyrimidine 

Downstream Products

• 1235451-38-3 tert-butyl (5-bromopyrimidin-2-yl)methylcarbamate 

Relevant articles and documents

Heterocyclic kinase inhibitor

The invention belongs to the technical field of medicines, and particularly relates to a heterocyclic DNA-PK kinase inhibitor compound shown as a general formula (I), a pharmaceutically acceptable salt and an isomer thereof, a pharmaceutical composition and preparation containing the compound, the pharmaceutically acceptable salt and the isomer thereof, a method for preparing the compound, the pharmaceutically acceptable salt and the isomer thereof, and application of the compound, the pharmaceutically acceptable salt and the isomer thereof.

TREATMENT OF CANCERS HAVING K-RAS MUTATIONS

The present invention provides a method of treating a cancer associated with a K- ras mutation in a subject in need thereof. The method comprises the steps of (1) identifying a subject with a cancer associated with a K-ras mutation; and (2) adminsiterign to the subject (i) an inhibitor of PI3 kinase and (ii) an HDAC inhibitor, wherein the PI3 kinase inhibitor and the HDAC inhibitor are administered in amounts which together are therapeutically effective.