cas 1244-78-6, 3-Hydroxy-3,4, 5,7-tetramethoxyflavone

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Looker et al.
p. 179,182
(1970)
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Zapesockonaya,Ban'kovskii
(1965)
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Briggs,Locker
p. 3131,3134
(1951)
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Chemical Studies on the Mistletoe. V. The Structure of Taxillusin, a New Flavonoid Glycoside Isolated from Taxillus kaempferi
A new flavonoid glycoside, taxillusin was isolated from Taxillus kaempferi (DC.) Danser and (2R,3R)-taxifolin 3-β-D-glucopyranoside 6''-gallate was assigned to this substance from studies on the hydrolysis products and from analyses of the 1H-NMR and carbon-13 NMR spectra.
Sakurai, Atsushi,Okumura, Yasuaki
p. 542 - 544
(1983)
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Nitrogen-containing derivatives of O-tetramethylquercetin: Synthesis and biological profiles in prostate cancer cell models
Forty-eight nitrogen-containing quercetin derivatives were synthesized from readily available rutin or quercetin for the in vitro evaluation of their biological profiles. The WST-1 cell proliferation assay data indicate that thirty-nine out of the forty-eight derivatives possess significantly improved antiproliferative potency as compared with quercetin and fisetin, as well as the parent 3,3′,4′,7-O-tetramethylquercetin toward both androgen-sensitive (LNCaP) and androgen-insensitive (PC-3 and DU145) human prostate cancer cell lines. 5-O-Aminoalkyl-3,3′,4′,7-O-tetramethylquercetins were established as a better scaffold for further development as anti-prostate cancer agents. Among them, 5-O-(N,N-dibutylamino)propyl-3,3′,4′,7-O-tetramethylquercetin (44) was identified as the optimal derivative with IC50 values of 0.55–2.82 μM, being over 35–182 times more potent than quercetin. The flow cytometry-based assays further demonstrate that 44 effectively activates PC-3 cell apoptosis.
Rajaram, Pravien,Jiang, Ziran,Chen, Guanglin,Rivera, Alyssa,Phasakda, Alison,Zhang, Qiang,Zheng, Shilong,Wang, Guangdi,Chen, Qiao-Hong
p. 227 - 239
(2019)
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Synthesis and antiproliferative activity of flavonoid triazolyl glycosides
Sixteen flavonoid triazolyl glycosides 4-19 were synthesized in good yields via Cu(I)-catalyzed azide-alkyne cycloadditions of terminal alkynes of flavonoids 1-3 with acetylated sugar azides followed by deacetylation with sodium methoxide in anhydrous met
Wang, Gang-Qiang,Yan, Li-Li,Wang, Qiu-An
p. 119 - 124
(2018)
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Design and synthesis of the 4H-chromenone derivatives against psoriasis
On basis of Quercetin moiety, two series of 20 new compounds were designed and synthesized accordingly in this study, and their anti-inflammatory activities in vitro and in vivo were evaluated. At last, compound 8A2: 3- (1- (2- (4- (5-bromo-2-chlorobenzoyl) piperazin-1-yl) ethyl)-1H-1,2,3-triazol-4-yl) methoxy)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one with low toxicity was found the best one for inhibiting of NO. Meanwhile, this compound could significantly inhibit the expression of IL-6 (Interleukin-6), TNF-α (Tumor necrosis factor-α) and IL-17 (Interleukin-17), and also significantly down-regulate IL-17 mRNA psoriasis model in vitro. Further studies were performed to establish mouse psoriasis model induced by Imiquimod (IMQ), and the preliminary mechanism indicated that compound 8A2 may alleviate mouse psoriasis through obstructed the JAK1/2-STAT1/3 pathway. This study should be provide a basis for further study of effective treatment of psoriasis.
Du, Jun Cheng,Han, Xu,Liu, Xin Hua,Yan, Yaoyao,Zhang, Famin,Zhu, Rende
(2022/02/03)

Pharmacokinetics and Metabolites of 12 Bioactive Polymethoxyflavones in Rat Plasma
Polymethoxyflavones (PMFs) are a subgroup of flavonoids possessing various health benefits. 3,5,7,4′-Tetramethoxyflavone (1), 5,6,7,4′-tetramethylflavone (2), 3,7,3′,4′-tetramethoxyflavone (3), 5,7,3′,4′-tetramethoxyflavone (4), 5-hydroxy-3,7,2′,4′-tetramethoxyflavone (5), 3,5,7,2′,4′-pentamethoxyflavone (6), 5-hydroxy-3,7,3′,4′-tetramethoxyflavone (7), 3-hydroxy-5,7,3′,4′-tetramethylflavone (8), 3,5,7,3′,4′-pentamethoxyflavone (9), 5-hydroxy-3,7,3′,4′,5′-pentamethoxyflavone (10), 3-hydroxy-5,7,3′,4′,5′-pentamethoxyflavone (11), and 3,5,7,3′,4′,5′-hexamethoxylflavone (12) were 12 bioactive and available PMFs. The aim of this study was to investigate the pharmacokinetic, metabolite, and antitumor activities as well as the structure-pharmacokinetic-antitumor activity relationships of these 12 PMFs to facilitate further studies of their medicinal potentials. The cytotoxicity of PMFs with a hydroxy group toward HeLa, A549, HepG2, and HCT116 cancer cell lines was generally significantly more potent than that of PMFs without a hydroxy group. Compounds 5, 7, 8, 10, and 11 were all undetectable in rat plasma, while compounds 1-4, 6, 9, and 12 were detectable. Both the number and position of hydroxy and methoxy groups played an important role in modulating PMF pharmacokinetics and metabolites.
Chen, Hongping,Ding, Haiyan,Hu, Yuan,Li, Dan,Liu, Youping,You, Qiang
p. 12705 - 12716
(2021/11/17)

Discovery and synthesis of rocaglaol derivatives inducing apoptosis in HCT116 cells via suppression of MAPK signaling pathway
Six rocaglaol derivatives were isolated from Dysoxylum gotadhora, and those compounds showed good cytotoxic activity with IC50 values ranging from 10 to 350 ng/mL against five different cancer cells. Obviously, further total synthesis of rocaglaol derivatives for medical chemistry study is of great significance. Then, twenty six rocaglaol derivatives including 25 new compounds were designed, synthesized, and evaluated for their cytotoxic activities against three human cancer cell lines: human colon cancer cells (HCT116), colorectal cancer stem cells (P6C), and human red leukocyte leukemia cells (HEL), using MTT assay. Most of derivatives showed good cytotoxic activities, with the lowest IC50 being 3.2 nM for HEL cells, which was 169 times stronger than that of the positive control (doxorubicin). Further mechanism study indicated that 11k could significantly suppress MAPK pathway in HCT116 cells, which may responsible for induction of apoptosis and cell cycle arrest.
Yang, Hao-Jie,Li, Ya-Nan,Yan, Chen,Yang, Jue,Zeng, Yan-Rong,Yi, Ping,Li, Yan-Mei,Hao, Xiao-Jiang,Yuan, Chun-Mao
(2021/03/16)

Synthesis, telomerase inhibitory and anticancer activity of new 2-phenyl-4H-chromone derivatives containing 1,3,4-oxadiazole moiety
Based on previous studies, 66 2-phenyl-4H-chromone derivatives containing amide and 1,3,4-oxadiazole moieties were prepared as potential telomerase inhibitors. The results showed most of the title compounds exhibited significantly inhibitory activity on telomerase. Among them, some compounds demonstrated the most potent telomerase inhibitory activity (IC50 50 = 6.41 μM). In addition, clear structure–activity relationships were summarised, indicating that the substitution of the methoxy group and the position, type and number of the substituents on the phenyl ring had significant effects on telomerase activity. Among them, compound A33 showed considerable inhibition against telomerase. Flow cytometric analysis showed that compound A33 could arrest MGC-803 cell cycle at G2/M phase and induce apoptosis in a concentration-dependent way. Meanwhile, Western blotting revealed that this compound could reduce the expression of dyskerin, which is a fragment of telomerase.
Han, Xu,Liu, Xin Hua,Ma, Duo,Yu, Yun Long,Zhang, Zhao Yan
p. 344 - 360
(2021/01/06)

Synthesis of Flavonols via Pyrrolidine Catalysis: Origins of the Selectivity for Flavonol versus Aurone
A novel synthetic method for flavonol from 2′-hydroxyl acetophenone and benzaldehyde promoted by pyrrolidine under an aerobic condition in water is established. This protocol was supported by efficient synthesis of 44 common examples and three natural products. The α, β-unsaturated iminium ion (enimine ion E) was proved to be the key intermediate in the reaction. H218O and 18O2 isotope tracking experiments demonstrated that both water and the aerobic atmosphere were necessary to ensure the transformation. The selectivity for flavonol or aurone was originated from solvent-triggered intermediates, which were determined by UV-visible spectra from isolated enimine. The phenol-iminium E-A is dominant in water and the ketoenamine intermediate E-B is prevalent in acetonitrile. In the presence of pyrrolidine and oxygen, E-A leads to flavonol through E-I, a zwitterionic-like phenoloxyl-iminium ion, following the key steps of cyclization and a [2 + 2] oxidation; E-B proceeds through path II, a radical process induced by photolysis of E-B with both pyrrolidine and oxygen, to afford aurone. Preliminary mechanistic studies are reported.
Xiong, Wei,Wang, Xiaohong,Shen, Xianyan,Hu, Cuifang,Wang, Xin,Wang, Fei,Zhang, Guolin,Wang, Chun
supporting information
p. 13160 - 13176
(2020/11/23)

Flavonoid aromatizing enzyme inhibitor as well as preparation method and application thereof
The invention relates to a flavonoid aromatizing enzyme inhibitor. Through cyanomethylation reaction and alkylation reaction, some substituted groups on the mother ring of a flavonoid compound are changed and a series of flavonoid compounds and derivatives thereof are synthesized. The structural general formula can be shown in the general formula in claims. In the structural general formula, R1 isselected from any one of -OH or -H, R2 is selected from any one of -H, -OCH3 or -OH, R3 is selected from any one of -H, -OH, -OCH2CN or -OCH3, R4 is selected from any one of -H, -OH, -CH2Ph or -2-(2-methoxy-2-oxo ethyl)benzyloxy, R5 is selected from any one of -H, -OCH2Ph or -OCH3, and R6 is selected from any one of -H, -OH or -OCH3. The flavonoid compounds have good inhibition effect on aromatizing enzyme; through activity test, the maximal value IC50 of inhibiting the activity of the aromatizing enzyme by the inhibitor is equal to 0.251 [mu]mol/L.
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(2018/07/30)

Synthesis and pharmacological evaluation of mutual prodrugs of aceclofenac with quercetin, vanillin and l-tryptophan as gastrosparing NSAIDS
Synthesis, physicochemical characterization and pharmacological evaluation of mutual prodrugs of aceclofenac with quercetin, vanillin and l-tryptophan have been attempted to develop novel gastrosparing NSAIDs, devoid of ulcerogenic side effects. The structures of synthesized prodrugs were confirmed by IR, 1H NMR, 13C NMR and mass spectroscopy. The hydrolysis kinetics studies were performed in simulated gastric fluid, simulated intestinal fluid and rat fecal matter. Its anti-inflammatory and ulcer index were analyzed along with estimation of biochemical parameters (GWM and Hexosamine), oxidative parameters (LPO, GSH, CAT, and SOD) and protein estimation. The results indicated that the synthesized prodrugs are chemically stable, biolabile and possesses optimum lipophilicity. They also exhibited retention of anti-inflammatory activity with reduced ulcerogenicity. The study showed that the mutual prodrugs are better in action compared to the parent drug and have fewer gastrointestinal side effects.
Rasheed, Arun,Lathika,Raju, Y. Prasanna,Mansoor,Azeem,Balan, Nija
p. 70 - 82
(2016/01/25)

Design, synthesis, and antiviral activity of novel rutin derivatives containing 1, 4-pentadien-3-one moiety
Rutin (compound 5) and some compounds (compounds 1e4 and 6) were isolated from Artemisia princeps Pamp (A. princeps Pamp.) and a series of novel rutin derivatives containing 1,4-pentadien-3-one moiety were designed and synthesized. The target compounds were characterized by proton nuclear magnetic resonance spectroscopy (1H NMR), carbon nuclear magnetic resonance spectroscopy (13C NMR), and ESIMS. Bioassay results indicated that some of the compounds showed good to excellent antiviral activities against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV) at 500 μg/mL in vivo. The 50% effective concentrations (EC50) of the compound 7r against CMV was 394.78 μg/mL, which was better than that of Ningnanmycin (432.22 μg/mL). These results indicated that novel rutin derivatives containing 1,4-pentadien-3-one moiety can effectively control CMV.
Han, Yu,Ding, Yan,Xie, Dandan,Hu, Deyu,Li, Pei,Li, Xiangyang,Xue, Wei,Jin, Linhong,Song, Baoan
p. 732 - 737
(2015/02/05)

Synthesis and anti-hypertensive effects of the twin drug of Nicotinic Acid and Quercetin Tetramethyl Ether
A novel twin drug consisting of nicotinic acid (VB3) and quercetin tetramethyl ether (QTME) has been synthesized as an antihypertensive in a total yield of 79.2% through methylation, hydrolysis, acylation and esterification starting from rutin. The structures of synthesized compounds were elucidated by 1H-NMR, 13C-NMR and elemental analysis. The anti-hypertensive effects of an oral daily dose (15 mg/kg) of the synthesized compounds in spontaneously hypertensive (SHR) rats and normotensive Wistar Kyoto (WKY) rats were analysed. The data demonstrate that the twin drug VB3-QTME both reduces the elevated blood pressure and prolongs the action time in SHR rats without effect on WKY rats. However, definitive evidence of a precise mechanism of action by which VB3-QTME might decrease blood pressure remains elusive. Based on the results, the therapeutic potential of this twin drug is discussed.
Wang, Zhonglei,Yang, Liyan,Cui, Shuai,Liang, Yingxi,Zhang, Xiaohua
p. 4791 - 4801
(2014/05/20)

Synthesis of methylated quercetin derivatives and their reversal activities on P-gp- and BCRP-mediated multidrug resistance tumour cells
Three methylated quercetins and a series of O-3 substituted 5,7,3′,4′-tetra-O-methylated quercetin derivatives have been synthesized and evaluated on the modulating activity of P-gp, BCRP and MRP1 in cancer cell lines. Compound 17 (with a 2-((4-methoxybenzoyl)oxy)ethyl at O-3) is the most potent P-gp modulator. Three derivatives, compound 9 (3,7,3′,4′-tetra-O-methylated quercetin), compound 14 (with a 2-((3-oxo-3-(3,4,5trimethoxyphenyl)prop-1-en-1-yl)oxy)ethyl at O-3) and compound 17, consistently exhibited promising BCRP-modulating activity. Interestingly, compound 17 was found to be equipotent against both P-gp and BCRP. Importantly, these synthetic quercetin derivatives did not exhibit any inherent cytotoxicity to cancer cell lines or normal mouse fibroblast cell lines. These quercetin derivatives can be employed as safe and effective modulators of P-gp- or BCRP-mediated drug resistance in cancer.
Yuan, Jian,Wong, Iris L.K.,Jiang, Tao,Wang, Si Wen,Liu, Tao,Jin Wen, Bin,Chow, Larry M.C.,Wan Sheng, Biao
scheme or table
p. 413 - 422
(2012/10/08)

Isolation and synthesis of flavonols and comparison of their antioxidant activity
Phytochemical investigation of the leaves of Astragalus beckari yielded four flavonol aglycones, namely kaempferol, quercetin, 5-deoxy kaempferol and fisitin. These isolated compounds were then synthesised in the laboratory using the Algar-Flyn-Oyamad reaction. Antioxidant activity of both the isolated and synthesised flavonoids was compared using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay method. The isolated flavonoids were found to be more active.
Hasan, Aurangzeb,Sadiq,Abbas,Mughal,Khan, Khalid M.,Ali, Muhammad
experimental part
p. 995 - 1003
(2010/09/05)

Design, synthesis and evaluation of mutual prodrug of 4-biphenylacetic acid and quercetin tetramethyl ether (BPA-QTME) as gastrosparing NSAID
A novel mutual prodrug consisting of 4-biphenylacetic acid (BPA) and quercetin tetramethyl ether (QTME) has been synthesized as a gastrosparing NSAID, devoid of ulcerogenic side effects. The physicochemical properties, including aqueous solubility, partition coefficient, chemical stability and enzymatic hydrolysis of synthesized derivative have been studied to assess its prodrug potential. Its antiinflammatory, antiulcer and analgesic activities were also evaluated. The results indicated that BPA-QTME derivative is chemically stable, biolabile and possesses optimum lipophilicity. The synthesized compound also exhibited retention of antiinflammatory activity with reduced ulcerogenicity. Based on these observations, the therapeutic potential of this mutual prodrug is discussed.
Madhukar, Mamta,Sawraj, Shruti,Sharma, Pritam Dev
body text
p. 2591 - 2596
(2010/07/08)

Elderberry flavonoids bind to and prevent H1N1 infection in vitro
A ionization technique in mass spectrometry called Direct Analysis in Real Time Mass Spectrometry (DART TOF-MS) coupled with a Direct Binding Assay was used to identify and characterize anti-viral components of an elderberry fruit (Sambucus nigra L.) extr
Roschek Jr., Bill,Fink, Ryan C.,McMichael, Matthew D.,Li, Dan,Alberte, Randall S.
experimental part
p. 1255 - 1261
(2010/06/19)

Darzens reaction of 2-bromo-4,6-dimethoxy-3(2H)-benzofuranone with aromatic aldehydes to form flavonoids
(Chemical Equation Presented) The applicability of 2-bromo-4,6-dimethoxy- 3(2H)-benzofuranone (1) to produce flavonoid-derived epoxides in the course of the Darzens reaction with aldehydes was investigated. However, instead of the epoxides, flavonols 3 and, in certain cases, benzofuranyl-substituted flavonols 4 were isolated. The generation of 3 is assumed due to a ring expansion of the initially formed epoxides. These flavonols can react with 1 to produce the unexpected 1:2 adducts 4 as minor products. The structure of the hexamethoxy derivative 4b (R1 = H, R2 = R3 = OMe) was confirmed by X-ray crystallographic analysis.
Ottersbach, Philipp A.,Bolek, David,Lepicova, Eva,Nieger, Martin,Guetschow, Michael
p. 1149 - 1153
(2008/12/21)

HETEROCYCLIC COMPOUNDS THAT BLOCK THE EFFECTS OF ADVANCED GLYCATION END PRODUCTS (AGE)
The present invention relates to novel compounds of Formula (Ia) or (Ib), their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. Formula (Ia), or Formula (Ib) in the above formulae L represents Formula (I), Formula (II) or -(CH2)1- Q represents Formula (III), or Formula (IV). The present invention also relates to a process for the preparation of the above said novel compounds, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory responses in tissues, including endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. The present invention also relates to compounds that act as modulators of Perlecan activity and expression. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating heparan sulfate proteoglycans (HSPG) such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as stenosis, restenosis, neointimal hyperplasia, and atherosclerosis. The compounds of Formula (I) are also useful for the treatment and/or prevention of cancer. The types of cancers include melanoma, prostate, leukemia, lymphoma, non-small lung cancers, cancer of the central nervous system, breast, colon, ovarian or renal cancer.
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Page/Page column 57

(2010/02/11)

[60]Fullerene-flavonoid dyads
A range of fullerene-chalcone, fullerene-flavone, and fullerene-chromone dyads, including a bis(flavonyl)-fullerene dyad, were prepared by 1,3-dipolar cycloaddition reactions of azomethine ylides to C60 and by cyclopropanation of C60 with flavonyl malonates. Synthetic and natural flavonoid derivatives were used as starting materials.
De La Torre, Maria D. L.,Rodrigues, Andrea G. P.,Tomé, Augusto C.,Silva, Artur M. S.,Cavaleiro, José A. S.
p. 3581 - 3592
(2007/10/03)

Regioselective hydroxylation of 2-hydroxychalcones by dimethyldioxirane towards polymethoxylated flavonoids
The flavone nucleus is part of a large number of natural products and medicinal compounds. In this presentation the novel regioselective hydroxylation of hydroxyarenes with DMD is described. The results showed further that flavonoids with 5-hydroxy group were selectively oxyfunctionalized at the para-position C8 carbon atom by DMD. Finally, according to this methodology, the naturally occurring isosinensetin, tangeretin, sinensetin, nobiletin, natsudaidain, gardenin B, 3,3′,4′,5,6,7,8- heptamethoxyflavone, quercetin and its derivatives were synthesized.
Chu, Han-Wei,Wu, Huan-Ting,Lee, Yean-Jang
p. 2647 - 2655
(2007/10/03)

Synthesis of [60]fullerene-quercetin dyads
Starting from quercetin, a natural flavonol with high antioxidant activity, three novel [60]fullerene-flavone derivatives were synthesized via cyclopropanation of C60.
De La Torre, Maria D.L.,Tomé, Augusto C.,Silva, Artur M.S.,Cavaleiro, José A.S.
p. 4617 - 4620
(2007/10/03)

Flavonol glycosides from the leaves of Sterculia urens roxb
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Khatoon,Khabiruddin,Asif,Ansari
p. 287 - 288
(2007/10/02)

A Flavonol-diglycoside from Melastoma melabathricum
A new flavonol-diglycoside was isolated from the methanolic extract of the aerial parts of Melastoma melabathricum.Its structure was established as quercetin-3-O-α-L-rhamnosyl-(1->2)-β-D-galactoside on the basis of physical and chemical evidences.
Dinda, B.,Saha, M. K.
p. 209 - 211
(2007/10/02)

Studies on the antihemorrhagic substances in herbs classified as hemostatics in Chinese medicine. IX. On the antihemorrhagic principles in Typha lactifolia L.
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Ishida,Umino,Tsuji,Kosuge
p. 4414 - 4420
(2007/10/02)

QUERCETIN 3-O-GALACTOSYL-(1 -> 6)-GLUCOSIDE, A COMPOUND FROM NARROWLEAF WETCH WITH ANTIBACTERIAL ACTIVITY
A new flavonol glycoside, quercetin 3-O-galactosyl-(1 -> 6)-glucoside, has been isolated from above-ground parts of narrowleaf vetch, Vicia angustifolia.Its antibacterial activity against Pseudomonas maltophilia and Enterobacter cloacae is compared with that of several other flavonol glycosides.Key Word Index - Vicia angustifolia; Leguminosae; flavonol glycoside; quercetin; antibacterial.
Waage, Susan K.,Hedin, Paul A.
p. 243 - 246
(2007/10/02)

TWO RHAMNETIN DIGALACTOSIDES AND AN OLEANOLIC ACID DIGALACTOSIDE FROM THE FLOWERS OF CASSIA LAEVIGATA
From the flowers of Cassia laevigata, two new rhamnetin glycosides, the 3-galactosyl(1->4)galactopyranoside and the related 3-galactosyl(1->6)galactopyranoside, and oleanolic acid 3-galactosyl(1->4)galactopyranoside have been isolated.These three glycosides have not been isolated earlier from any plant source.The known compounds quercetin, docosyl alcohol, carnaubyl alcohol, ceryl alcohol and octacosanol have also been obtained.Key Word Index - Cassia laevigata; Leguminosae; flowers; rhamnetin 3-galactosyl(1->4)galactoside; rhamnetin 3-galactosyl(1->6)galactoside; oleanolic acid 3-galactosyl(1->4)galactoside.
Singh, J.
p. 1832 - 1833
(2007/10/02)

XANTHONE AND FLAVONOL CONSTITUENTS OF SWERTIA HOOKERI
The whole plant of Swertia hookeri, collected at flowering has been shown to contain two tri- and nine tetraoxygenated free, glucosyloxy, and stearyl ester xanthones and one flavonol stearyl ester.Among these, three are previously unreported in nature and one was known previously only as a synthetic compound.The xanthones are based on 1,3,5-, 1,3,5,8- and 1,3,7,8-oxygenated systems with the middle oxygenation pattern predominating.The two ester compounds appeared only at the flowering stage.Plants collected at the pre-flowering stage gave the corresponding free compounds.The biochemical and biological significance of these findings are appraised.Key Word Index - Swertia hookeri; Gentianaceae; 1-O-stearyl-3,5-dimethoxyxanthone; 3-O-stearyl-3',4',5,7-tetra-O-methylquercetin; 1-hydroxy-3,5-dimethoxyxanthone; tetraoxygenated xanthones; 8-O-β-D-glucosyl-1,3-dihydroxy-5-methoxyxanthones; 8-O-β-D-glucosyl-1,5-dihydroxy-3-methoxyxanthone.
Ghosal, Shibnath,Biswas, Kanika,Jaiswal, Dinesh K.
p. 123 - 126
(2007/10/02)

Studies on the Constituents of Apocynacae Plants. Gas Chromatography-Mass Spectrometric Determination of New Flavanoid Triglycosides from the Leaves of Cerbera manghas L.
Two new flavonol triglycosides, named manghaslin(I) and clitorin(II), were isolated from the leaves of Cerbera manghas L. (Apocynaceae).The structures of I and II were elucidated as quertecin-3-O-L-rhamnosyl-(12)-O6)> D-glucoside(I) and kaempferol-3-O-L-rhamnosyl-(12)-O-6)> D-glucoside(II), respectively, by chemical and gas chromatography-mass spectrometric studies.Keywords-Cerbera manghas L.; Apocynaceae; flavonol triglycerides; manghaslin; clitorin; gas chromatography-mass spectrometry; photohydrolysis; mass spectrum; methanolysis.
Sakushima, Akiyo,Hisada, Sueo,Ogihara, Yukio,Nishibe, Sansei
p. 1219 - 1223
(2007/10/02)