An oxazetidine amino acid for chemical protein synthesis by rapid, serine-forming ligations
Amide-forming ligation reactions allow the chemical synthesis of proteins by the union of unprotected peptide segments, and enable the preparation of protein derivatives not accessible by expression or bioengineering approaches. The native chemical ligati
MODULATORS OF HEMOGLOBIN FOR THE TREATMENT OF SICKLE CELL DISEASE
The present disclosure relates to compounds of the general formula (I) and pharmaceutical compositions containing them. The compounds are suitable as modulators of hemoglobin and thus useful in treating disorders mediated by hemoglobin such as sickle cell disease.
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Paragraph 0274
(2020/05/15)
Carbonyl-inserted organo-hybrids of a Dawson-type phosphovanadotungstate: Scope and chemoselective oxidation catalysis
The Dawson-type polyoxometalate (POM) [P2V3W 15O62]9- is a prototype for inclusion of carbonyls of amides, ureas, carbamates, and thiocarbamates into polyoxometallic structures. The carbonyl-inserted POMs catalyze the oxidation of sulfides. Chemoselectivity depends primarily on the proton content of the POM, but it is also influenced by the organic substituent.
Catalytic Asymmetric Construction of Morpholines and Piperazines by Palladium-Catalyzed Tandem Allylic Substitution Reactions
Reaction of 1,4-diacetoxy-cis-2-butene (1a) with 2-(benzylamino)ethanol (2a) was catalyzed by a palladium complex (5 mol percent) coordinated with (R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl to give optically active (R)-4-benzyl-2-vinylmorpholine (3a)
Uozumi, Yasuhiro,Tanahashi, Asako,Hayashi, Tamio
p. 6826 - 6832
(2007/10/02)
Unambiguous Synthesis of 3-Aryloxymethylmorpholine Hydrochlorides Without Ring Enlargement Side Reactions
The unambiguous synthesis of 3-naphthyloxymorpholine hydrochloride appetite suppressants is reportet.Chemoselective reduction of 4-benzyl-5-oxomorpholine-3-carboxylic acid and its derivatives is described under various metal hydride reducing conditions.
Brown, George R.,Foubister, Alan J.
p. 1401 - 1403
(2007/10/02)
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