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124691-76-5

5,6-Dichloro-1H-indazole, a chemical compound with the molecular formula C7H4Cl2N2, is a pale yellow to brownish solid. It is recognized for its diverse biological activities, such as anti-inflammatory, anticholinesterase, and antibacterial properties. 5,6-DICHLORO-1H-INDAZOLE is also of interest in the scientific community due to its potential as a building block in the development of new drugs and agrochemicals. Furthermore, 5,6-dichloro-1H-indazole has demonstrated the ability to inhibit the growth of certain cancer cells, positioning it as a promising candidate for further research and development in oncology.

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  • 124691-76-5 Structure

  • Basic information

    1. Product Name: 5,6-DICHLORO-1H-INDAZOLE
    2. Synonyms: 1H-INDAZOLE,5,6-DICHLORO-;5,6-DICHLORO-1H-INDAZOLE;5,6-Dichloroindazole
    3. CAS NO:124691-76-5
    4. Molecular Formula: C7H4Cl2N2
    5. Molecular Weight: 187.029
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 124691-76-5.mol

  • Chemical Properties

    1. Melting Point: 204 °C
    2. Boiling Point: 347.308 °C at 760 mmHg
    3. Flash Point: 194.698 °C
    4. Appearance: /
    5. Density: 1.572 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C(protect from light)
    8. Solubility: N/A
    9. PKA: 11.63±0.40(Predicted)
    10. CAS DataBase Reference: 5,6-DICHLORO-1H-INDAZOLE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 5,6-DICHLORO-1H-INDAZOLE(124691-76-5)
    12. EPA Substance Registry System: 5,6-DICHLORO-1H-INDAZOLE(124691-76-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 124691-76-5(Hazardous Substances Data)

124691-76-5 Usage

Uses

Used in Pharmaceutical Industry:
5,6-Dichloro-1H-indazole is used as an intermediate in the synthesis of pharmaceuticals for its potential to contribute to the development of new drugs with various therapeutic applications.
Used in Agrochemical Development:
In the agrochemical industry, 5,6-dichloro-1H-indazole is utilized as a building block in the creation of new agrochemicals, potentially enhancing crop protection and yield.
Used in Oncology Research:
5,6-Dichloro-1H-indazole is used as a research compound in oncology for its demonstrated inhibitory effects on the growth of certain cancer cells, making it a candidate for further exploration in cancer treatment development.
Used in Antibacterial Applications:
Leveraging its antibacterial properties, 5,6-dichloro-1H-indazole is applied in the development of new antimicrobial agents to combat bacterial infections.
Used in Anti-inflammatory and Anticholinesterase Research:
5,6-Dichloro-1H-indazole is used as a research compound in studies focused on inflammation and cholinesterase inhibition, potentially leading to advancements in treatments for inflammatory diseases and neurological disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 124691-76-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,6,9 and 1 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 124691-76:
(8*1)+(7*2)+(6*4)+(5*6)+(4*9)+(3*1)+(2*7)+(1*6)=135
135 % 10 = 5
So 124691-76-5 is a valid CAS Registry Number.

124691-76-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 5,6-Dichloro-1H-indazole

1.2 Other means of identification

Product number -
Other names 5,6-DICHLOROINDAZOLE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:124691-76-5 SDS

124691-76-5Relevant articles and documents

PYRROLOPYRAZINE KINASE INHIBITORS

-

, (2013/03/28)

The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists

Shimada, Itsuro,Maeno, Kyoichi,Kazuta, Ken-ichi,Kubota, Hideki,Kimizuka, Tetsuya,Kimura, Yasuharu,Hatanaka, Ken-ichi,Naitou, Yuki,Wanibuchi, Fumikazu,Sakamoto, Shuichi,Tsukamoto, Shin-ichi

, p. 1966 - 1982 (2008/09/21)

A series of novel indazole derivatives were synthesized, and their structure-activity relationships examined in order to identify potent and selective 5-HT2C receptor agonists. Among these compounds, (S)-2-(7-ethyl-1H-furo[2,3-g]indazol-1-yl)-1-methylethylamine (YM348) had a good in vitro profile, that is, high agonistic activity to the human 5-HT2C receptor subtype (EC50 = 1.0 nM) and high selectivity over 5-HT2A receptors. This compound was also effective in a rat penile erection model when administered po.

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