2387-08-8

Usage

Uses

Used in Pharmaceutical Industry:
4,5-Dichloro-2-methylaniline is used as a building block reagent for the synthesis of various drug analogues and pharmaceutical goods. Its unique chemical structure allows it to be a valuable component in the development of new medications, potentially contributing to the treatment of various diseases and health conditions.
Used in Chemical Synthesis:
In the chemical industry, 4,5-Dichloro-2-methylaniline is employed as an intermediate in the synthesis of a range of chemical products. Its reactivity and functional groups make it a versatile compound for creating various organic compounds with specific applications in different sectors, such as agriculture, materials science, and specialty chemicals.

InChI:InChI=1/C7H7Cl2N/c1-4-2-5(8)6(9)3-7(4)10/h2-3H,10H2,1H3

Upstream product

• 24251-12-5 tertiary amyl hypochlorite 
• 7494-45-3 1,2-dichloro-4-methyl-5-nitrobenzene 
• 56-23-5 tetrachloromethane 

Downstream Products

• 124691-76-5 5,6-dichloro-1H-indazole 
• 1426421-77-3 5,6-dichloro-3-iodo-1-methyl-1H-indazole 
• 1426421-76-2 5,6-dichloro-3-iodo-1H-indazole 
• 95-79-4 5-chloro-2-methyl-benzenamine 
• 306277-20-3 4,5-Dichloro-2-methyl-benzonitrile 
• 50-82-8 2,4,5-trichlorobenzoic acid 
• 6639-30-1 2,4,5-trichlorotoluene 
• 128924-46-9 C₁₅H₁₄Cl₂N₂O₃S 

Relevant academic research and scientific papers

PYRROLOPYRAZINE KINASE INHIBITORS

The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists

A series of novel indazole derivatives were synthesized, and their structure-activity relationships examined in order to identify potent and selective 5-HT2C receptor agonists. Among these compounds, (S)-2-(7-ethyl-1H-furo[2,3-g]indazol-1-yl)-1-methylethylamine (YM348) had a good in vitro profile, that is, high agonistic activity to the human 5-HT2C receptor subtype (EC50 = 1.0 nM) and high selectivity over 5-HT2A receptors. This compound was also effective in a rat penile erection model when administered po.

CYCLIC AMIDINES USEFUL AS NMDA NR2B ANTAGONISTS

The invention encompasses novel compounds of Formula I as well as a method of treating NMDA mediated diseases comprising administration to a patient in need of such treatment a non-toxic amount of a compound of Formula I effective to block the NMDA NR2B r

Transition metal catalysed cross-coupling between benzylic halides and aryl nucleophiles. Synthesis of some toxicologically interesting tetrachlorobenzyltoluenes

The aryl-benzyl cross-coupling in the presence of copper-, nickel- and palladium-catalysts has been investigated with a number of chlorine- and methyl-substituted arylmetal compounds ArM (M = MgBr, ZnCl) and (substituted) benzylic halides ArCH2X. The results have been applied in the selective synthesis of some toxicologically interesting tetrachlorobenzyltoluenes.