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4-Fluoro-5-methoxy-2-nitroaniline is a chemical compound with the molecular formula C7H7FN2O3. It is an aniline derivative characterized by the presence of a nitro group, a methoxy group, and a fluoro group. 4-Fluoro-5-methoxy-2-nitroaniline is recognized for its versatility in undergoing various chemical reactions, which allows for the synthesis of a broad spectrum of products. Due to its chemical properties, it is a valuable intermediate in the fields of organic synthesis, pharmaceuticals, and agrochemicals, and has potential applications in materials science.

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  • 125163-12-4 Structure
  • Basic information

    1. Product Name: 4-Fluoro-5-methoxy-2-nitroaniline
    2. Synonyms: 4-Fluoro-5-methoxy-2-nitroaniline;BenzenaMine, 4-fluoro-5-Methoxy-2-nitro-;4-Fluoro-5-methoxy-2-nitro-phenylamine
    3. CAS NO:125163-12-4
    4. Molecular Formula: C7H7FN2O3
    5. Molecular Weight: 186.1404832
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 125163-12-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-Fluoro-5-methoxy-2-nitroaniline(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-Fluoro-5-methoxy-2-nitroaniline(125163-12-4)
    11. EPA Substance Registry System: 4-Fluoro-5-methoxy-2-nitroaniline(125163-12-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 125163-12-4(Hazardous Substances Data)

125163-12-4 Usage

Uses

Used in Organic Synthesis:
4-Fluoro-5-methoxy-2-nitroaniline is used as a key intermediate in organic synthesis for the production of a variety of complex organic compounds. Its unique combination of functional groups facilitates multiple reaction pathways, making it a versatile building block in the synthesis of specialty chemicals.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 4-Fluoro-5-methoxy-2-nitroaniline serves as a crucial precursor in the synthesis of certain drugs. Its presence in the molecular structure can impart specific therapeutic properties, contributing to the development of new medications with targeted effects.
Used in Agrochemicals:
4-Fluoro-5-methoxy-2-nitroaniline is also utilized in the agrochemical sector, where it is employed as a starting material for the synthesis of various pesticides and other agricultural chemicals. Its role in these applications is to provide the necessary chemical structure for effective pest control and crop protection.
Used in Materials Science:
4-Fluoro-5-methoxy-2-nitroaniline has been studied for its potential use in materials science, where it may contribute to the development of new materials with specific properties. Its unique structure could be leveraged to create materials with tailored characteristics for use in various applications.
Safety Considerations:
It is important to handle 4-Fluoro-5-methoxy-2-nitroaniline with care, as it can be harmful if ingested or inhaled and may cause irritation to the skin and eyes. Proper safety measures should be taken during its use to minimize potential health risks.

Check Digit Verification of cas no

The CAS Registry Mumber 125163-12-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,5,1,6 and 3 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 125163-12:
(8*1)+(7*2)+(6*5)+(5*1)+(4*6)+(3*3)+(2*1)+(1*2)=94
94 % 10 = 4
So 125163-12-4 is a valid CAS Registry Number.

125163-12-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Fluoro-5-methoxy-2-nitroaniline

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:125163-12-4 SDS

125163-12-4Relevant articles and documents

NOVEL NUCLEOSIDE PHOSPHORAMIDATE COMPOUND AND USE THEREOF

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Paragraph 0147, (2015/11/24)

The present invention provides a novel nucleoside phosphoramidate compound, or a stereoisomer, salt, hydrate, solvate or crystal thereof for the treatment of Flaviviridae family viral infection, especially hepatitis C viral infection. The present invention also provides the pharmaceutical composition comprising a compound of the present invention, or a stereoisomer, salt, hydrate, solvate or crystal thereof and a use of the compound or the composition of the present invention in the treatment of Flaviviridae family viral infection, especially hepatitis C viral infection. The compound of the present invention has a good anti-HCV effect.

HEPATITIS C VIRUS INHIBITORS

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, (2016/01/21)

Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

Benzofurazan derivatives as antifungal agents against phytopathogenic fungi

Wang, Lili,Zhang, Ying-Ying,Wang, Lei,Liu, Feng-You,Cao, Ling-Ling,Yang, Jing,Qiao, Chunhua,Ye, Yonghao

, p. 535 - 542 (2014/06/09)

A series of benzofurazan derivatives were prepared and evaluated for their biological activities against four important phytopathogenic fungi, namely, Rhizoctonia solani, Sclerotinia sclerotiorum, Fusarium graminearum and Phytophthora capsici, using the mycelium growth inhibition method. The structures of these compounds were characterized by1H NMR,13C NMR, and HRMS. N-(3-chloro-4-fluorophenyl)-7-nitrobenzo[c][1,2,5] oxadiazol-4-amine (A3) displayed the maximum antifungal activity against R. solani (IC50= 1.91 μg/mL), which is close to that of the positive control Carbendazim (IC50= 1.42 μg/mL). For other benzofurazan derivatives with nitro group at R4position (A series), 9 out of 30 compounds exhibited high antifungal effect against strain R. solani, with IC50values less than 5 μg/mL. Most of the derivatives with substituents at R2and R3positions (B series) displayed moderate growth inhibition against S. sclerotiorum (IC504position and another conjugated aromatic ring at the R1position of the phenyl ring displayed high antifungal capability against strain R. solani. Compounds with substituents at R2and R3position had moderate efficacy against strain S. sclerotiorum.

Optimization of physicochemical properties and safety profile of novel bacterial topoisomerase type II inhibitors (NBTIs) with activity against Pseudomonas aeruginosa

Reck, Folkert,Ehmann, David E.,Dougherty, Thomas J.,Newman, Joseph V.,Hopkins, Sussie,Stone, Gregory,Agrawal, Nikunj,Ciaccio, Paul,McNulty, John,Barthlow, Herbert,O'Donnell, Jennifer,Goteti, Kosalaram,Breen, John,Comita-Prevoir, Janelle,Cornebise, Mark,Cronin, Mark,Eyermann, Charles J.,Geng, Bolin,Carr, Greg R.,Pandarinathan, Lakshmipathi,Tang, Xuejun,Cottone, Andrew,Zhao, Liang,Bezdenejnih-Snyder, Natascha

, p. 5392 - 5409 (2014/12/10)

Type II bacterial topoisomerases are well validated targets for antimicrobial chemotherapy. Novel bacterial type II topoisomerase inhibitors (NBTIs) of these targets are of interest for the development of new antibacterial agents that are not impacted by

Chemo-enzymatic synthesis and biological evaluation of 5,6-disubstituted benzimidazole ribo- and 2′-deoxyribonucleosides

Konstantinova, Irina D.,Selezneva, Olga M.,Fateev, Ilja V.,Balashova, Tamara A.,Kotovskaya, Svetlana K.,Baskakova, Zoya M.,Charushin, Valery N.,Baranovsky, Alexander V.,Miroshnikov, Anatoly I.,Balzarini, Jan,Mikhailopulo, Igor A.

, p. 272 - 280 (2013/02/25)

A number of new 5,6-disubstituted benzimidazoles have been prepared and their substrate properties for recombinant E. coli purine nucleoside phosphorylase (PNP; the product of the deoD gene) in the transglycosylation reaction were investigated. The heterocyclic bases showed good substrate activity for PNP and the ribo- and 2-deoxyribonucleosides were synthesized. The predominant (OMe and OEt) or exclusive (Oi-Pr, morpholino, and N-methylpiperazino) formation of the 5-substituted 6-fluoro-1-(β-d- ribofuranosyl)benzimidazoles was observed. The formation of the regioisomeric 6- methoxy-, 6-ethoxy-, or 6-isopropoxy-substituted 1-(2-deoxy-β-d- ribofuranosyl)-5-fluorobenzimidazoles was observed in the trans-2- deoxyribosylation reaction of the corresponding bases. The predominant or exclusive formation of the regioisomeric N1-nucleosides with bulky 5-substituents of 6-fluorobenzimidazole points to a large hydrophobic pocket in the E. coli PNP active site that can accommodate these groups. The biological activity of the synthesized nucleosides was studied and revealed no inhibitory activity against a broad variety of DNA and RNA viruses. The compounds also lacked significant cytotoxicity. Georg Thieme Verlag Stuttgart New York.

PYRROLO[1,2-A]QUINOXALIN-5-(4H)-YL)SULFONYLS AND CARBONYLS AND THEIR USE AS ESTROGENIC AGENTS

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Page/Page column 64, (2008/06/13)

This invention provides estrogen receptor modulators having the structure: wherein R1 to R7, R9 and R10 X, Y, and Z are as defined in the specification; or a pharmaceutically acceptable salt thereof.

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