125273-86-1

Basic information

• Product Name: 2-(cyclohexylcarbonyl)-2,3,6,7-tetrahydro-4H-pyrazino [2,1-alpha]isoquinolin-4-one
• Synonyms: 2-(cyclohexylcarbonyl)-2,3,6,7-tetrahydro-4H-pyrazino [2,1-alpha]isoquinolin-4-one;Praziquantel Related CoMpound B;Praziquantel Related Compound B (50 mg) (2-(cyclohexylcarbonyl)-2,3,6,7-tetrahydro-4H-pyrazino [2,1-alpha]isoquinolin-4-one);4H-Pyrazino[2,1-a]isoquinolin-4-one, 2-(cyclohexylcarbonyl)-2,3,6,7-tetrahydro-;2-Cyclohexanecarbonyl-2,3,6,7-tetrahydro-pyrazino[2,1-a]isoquinolin-4-one
• CAS NO: 125273-86-1
• Molecular Formula: C19H22N2O2
• Molecular Weight: 310.39018
• Mol File: 125273-86-1.mol

Chemical Properties

• Boiling Point: 569.3±50.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• PKA: -1.34±0.20(Predicted)
• CAS DataBase Reference: 2-(cyclohexylcarbonyl)-2,3,6,7-tetrahydro-4H-pyrazino [2,1-alpha]isoquinolin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(cyclohexylcarbonyl)-2,3,6,7-tetrahydro-4H-pyrazino [2,1-alpha]isoquinolin-4-one(125273-86-1)
• EPA Substance Registry System: 2-(cyclohexylcarbonyl)-2,3,6,7-tetrahydro-4H-pyrazino [2,1-alpha]isoquinolin-4-one(125273-86-1)

Safety Data

• Hazardous Substances Data: 125273-86-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(Cyclohexylcarbonyl)-2,3,6,7-tetrahydro-4H-pyrazino[2,1-alpha]isoquinolin-4-one is used as a pharmaceutical compound for its potential therapeutic effects. The compound's unique structure may allow it to interact with specific biological targets, making it a candidate for the development of new drugs.
Used in Chemical Research:
In the field of chemical research, 2-(cyclohexylcarbonyl)-2,3,6,7-tetrahydro-4H-pyrazino[2,1-alpha]isoquinolin-4-one can be used as a starting material or intermediate for the synthesis of other complex organic molecules. Its unique structure may provide new insights into the design and synthesis of novel compounds with various applications.
Used in Anthelmintic Applications:
As a related compound to Praziquantel, which is an effective anthelmintic against flatworms, 2-(cyclohexylcarbonyl)-2,3,6,7-tetrahydro-4H-pyrazino[2,1-alpha]isoquinolin-4-one may have potential applications in the development of new anthelmintic drugs. Its structural similarity to Praziquantel suggests that it could be used to target and treat parasitic infections caused by flatworms.

Upstream product

• 55268-74-1 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one 
• 1372607-34-5 1-cyclohexanecarbonyl-3-methoxy-1,2-dihydropyrazine 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 1074-16-4 2-bromophenylethyl alcohol 
• 406954-89-0 1-[2-(2-bromophenyl)ethyl]-4-(cyclohexylcarbonyl)-1,3,4-trihydropyrazin-2-one 
• 171734-72-8 toluene-4-sulfonic acid 2-(2-bromophenyl)ethyl ester 

Relevant articles and documents

Preparation method of praziquantel impurity B

The invention relates to the technical field of medicine preparation, in particular to a preparation method of a praziquantel impurity B. The preparation method comprises the following steps: adding sublimed sulfur and Fe2O3 into praziquantel, and carryin

A palladium-catalyzed intramolecular Heck/Hydrogenation approach towards the synthesis of praziquantel

Starting from 3-methoxy N-acylpyrazinium salts, a new approach towards the synthesis of the antischistosomal drug praziquantel (PZQ) has been developed. Utilization of a palladium-catalyzed intramolecular Heck reaction to form dehydro-PZQ followed by a Hydrogenation step, in a stepwise or one-pot manner, allowed for the gram scale synthesis of PZQ in 4 or 5 steps and in good overall yields. This methodology proved to be well suited for generating the pyrazino[1,2-a] isoindole and pyrazino[1,2-a] benzazepine analogues of PZQ.