Didehydro praziquantel

Base Information

Chemical Name:Didehydro praziquantel
CAS No.:125273-86-1
Molecular Formula:C₁₉H₂₂N₂O₂
Molecular Weight:310.396
Hs Code.:2933599550
European Community (EC) Number:642-209-5
UNII:SWR6DIS4IU
Nikkaji Number:J246.152H
Wikidata:Q27289435
Mol file:125273-86-1.mol

Synonyms:125273-86-1;Didehydro praziquantel;1,2-Deshydro Praziquantel;SWR6DIS4IU;4H-Pyrazino[2,1-a]isoquinolin-4-one, 2-(cyclohexylcarbonyl)-2,3,6,7-tetrahydro-;2-(cyclohexanecarbonyl)-6,7-dihydro-3H-pyrazino[2,1-a]isoquinolin-4-one;2-(Cyclohexylcarbonyl)-2,3,6,7-tetrahydro-4H-pyrazino[2,1-a]isoquinolin-4-one;2-(Cyclohexylcarbonyl)-2,3,6,7-tetrahydro-4H-pyrazino(2,1-a)isoquinolin-4-one;2-(Cyclohexylcarbonyl)-2,3,6,7-tetrahydro-4H-pyrazino (2,1-a)isoquinolin-4-one;4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-2,3,6,7-tetrahydro-;UNII-SWR6DIS4IU;2-(cyclohexylcarbonyl)-2,3,6,7-tetrahydro-4h-pyrazino [2,1-a]isoquinolin-4-one;Praziquantel specified impurity B [EP];Praziquantel EP Impurity B;SCHEMBL11472559;BCP31631;MFCD29060052;AKOS030241398;PRAZIQUANTEL IMPURITY B [EP IMPURITY];A899046;Q27289435;2-Cyclohexanecarbonyl-2,3,6,7-tetrahydro-pyrazino[2,1-a]isoquinolin-4-one;2,3,6,7-Tetrahydro-4H-2-(cyclohexylcarbonyl)-pyrazino[2,1-a]isoquinolin-4-one;2-(Cyclohexanecarbonyl)-2,3,6,7-tetrahydro-4H-pyrazino[2,1-a]isoquinolin-4-one;2-(cyclohexylcarbonyl)-2,3,6,7-tetrahydro-4H-pyrazino [2,1-alpha]isoquinolin-4-one

Suppliers and Price of Didehydro praziquantel

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1,2-DeshydroPraziquantel
10mg
$ 180.00

Sigma-Aldrich
Praziquantel Related Compound B
50mg
$ 1260.00

Total 11 raw suppliers

Chemical Property of Didehydro praziquantel

Chemical Property:

Boiling Point:569.3±50.0 °C(Predicted)
PKA:-1.34±0.20(Predicted)
PSA：40.62000
Density:1.25±0.1 g/cm3(Predicted)
LogP:2.66800
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:310.168127949
Heavy Atom Count:23
Complexity:522

Purity/Quality:

>97% ^*data from raw suppliers

1,2-DeshydroPraziquantel ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(CC1)C(=O)N2CC(=O)N3CCC4=CC=CC=C4C3=C2
Uses 1,2-Deshydro Praziquantel is a related compound to Praziquantel (P702095), anthelmintic, effective against flatworms. Praziquantel USP Related Compound B.

Technology Process of Didehydro praziquantel

There total 13 articles about Didehydro praziquantel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 406954-89-0
1-[2-(2-bromophenyl)ethyl]-4-(cyclohexylcarbonyl)-1,3,4-trihydropyrazin-2-one

: 125273-86-1
2-(Cyclohexylcarbonyl)-2,3,6,7-tetrahydro-4H-pyrazino-<2,1-a>-isoquinolin-4-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 18h; Reagent/catalyst; Solvent; Temperature; Catalytic behavior; Inert atmosphere;
DOI:10.1016/j.tet.2017.10.006

Reference yield: 80.0%

: 406954-89-0
1-[2-(2-bromophenyl)ethyl]-4-(cyclohexylcarbonyl)-1,3,4-trihydropyrazin-2-one

: 125273-86-1
2-(Cyclohexylcarbonyl)-2,3,6,7-tetrahydro-4H-pyrazino-<2,1-a>-isoquinolin-4-one

: 94494-35-6
4-(cyclohexylcarbonyl)-3,4-dihydro-1-(2-phenylethyl)-2(1H)-pyrazinone

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 2-methyltetrahydrofuran; at 80 ℃; for 22h; Inert atmosphere;
DOI:10.1016/j.tet.2017.10.006