125369-57-5

Basic information

• Product Name: 2,6-DIFLUORO-4-METHOXYBENZAMIDE
• Synonyms: 2,6-DIFLUORO-4-METHOXYBENZAMIDE
• CAS NO: 125369-57-5
• Molecular Formula: C₈H₇F₂NO₂
• Molecular Weight: 187.14
• Mol File: 125369-57-5.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,6-DIFLUORO-4-METHOXYBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIFLUORO-4-METHOXYBENZAMIDE(125369-57-5)
• EPA Substance Registry System: 2,6-DIFLUORO-4-METHOXYBENZAMIDE(125369-57-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 125369-57-5(Hazardous Substances Data)

Usage

Physical form

White solid

Common uses

Pharmaceutical research and development, building block for synthesizing biologically active molecules, creating new drug candidates, studying interactions with biological systems, intermediate in the production of specialty chemicals

Notable properties

Versatile compound with a wide range of applications in pharmaceuticals and chemical research.

Upstream product

• 93343-10-3 3,5-difluoroanisol 
• 125369-56-4 2,6-difluoro-4-methoxybenzoyl chloride 
• 123843-65-2 2,6-difluoro-4-methoxybenzoic acid 

Downstream Products

• 123843-66-3 2,6-Difluoro-4-methoxybenzonitrile 
• 944742-29-4 5-fluoro-7-methoxyquinazolin-4(3H)-one 
• 123843-54-9 4-butoxy-2-fluorobenzoic acid 
• 123843-69-6 4-cyano-3,5-difluorophenyl 4-pentylbenzoate 
• 123843-57-2 2,6-difluoro-4-hydroxybenzonitrile 
• 880885-41-6 2-amino-6-(2-ethoxymethyl-2H-pyrazol-3-yl)-4-methoxy-benzonitrile 
• 880885-38-1 2-amino-6-(4-chloro-pyrazol-1-yl)-4-methoxy-benzonitrile 
• 880885-40-5 2-amino-4-methoxy-6-(2-methyl-2H-pyrazol-3-yl)-benzonitrile 
• 880885-39-2 2-amino-4-methoxy-6-(3-methyl-pyrazol-1-yl)-benzonitrile 
• 880885-42-7 2-amino-4-methoxy-6-thiazol-2-yl-benzonitrile 
• 880885-37-0 2-amino-4-methoxy-6-pyrazol-1-yl-benzonitrile 
• 601516-61-4 2-amino-6-iodo-4-methoxy-benzonitrile 
• 601516-55-6 2-fluoro-6-iodo-4-methoxy-benzonitrile 
• 601517-02-6 2-amino-6-fluoro-4-methoxybenzonitrile 

Relevant articles and documents

QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS

The present application relates to novel quinazoline compounds as inhibitors of type I receptor tyrosine kinases, the pharmaceutical compositions comprising one or more of the compounds and salts thereof as an active ingredient, and the use of the compounds and salts thereof in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals and especially in humans.

Synthesis of 5-heterocyclic substituted quinazolin-4-ones via 2-aminobenzonitrile derivatives

Two routes to prepare a series of six 5-heterocyclic substituted 2-chloro-7-methoxyquinazolin-4-ones are described, where the heterocycle is a substituted or unsubstituted 1-pyrazolyl, 5-pyrazolyl or 2-thiazolyl group. Both routes proceeded via key 2-amin

The Synthesis and Transition Temperatures of Some Fluoro-Substituted 4-Cyanophenyl and 4-Cyanobiphenyl-4'-yl 4-Pentyl- and 4-Butoxy-Benzoates

A series of 4-cyanophenyl 4-X-benzoates and a series of 4-cyanobiphenyl-4'-yl 4-X-benzoates (X= pentyl, butoxy) have been prepared without fluoro-substitution and with mono-fluoro to tetra-fluoro-substitution; all possible combinations of substitution patterns at the positions ortho- to the cyano group and ortho- to the carboxylate group have been obtained in an attempt to determine the structural features which are responsible for some members of these series showing very large positive values of dielectric anisotropy.The synthesis of novel precursors required for the preparation of these esters is described and the melting points and transition temperatures of the esters are discussed and an explanation is provided for the variation of Tn-1 values with position and extent of fluoro-substitution. - Keywords: Fluoro-substitution, phenyl and biphenyl benzoates, terminal cyano namatogens.