93343-10-3

Basic information

• Product Name: 3,5-Difluoroanisole
• Synonyms: 3,5-DIFLUOROANISOLE;3,5-DIFLUORO-1-METHOXYBENZENE;3,5-Difluoroanisole,97%;3,5-Difluoroanisole 98%;3,5-Difluoroanisole98%;Benzene, 1,3-difluoro-5-methoxy-;3，5-difluoroanisile;1,3-Difluoro-5-methoxybenzene, 3,5-Difluorophenyl methyl ether
• CAS NO: 93343-10-3
• Molecular Formula: C₇H₆F₂O
• Molecular Weight: 144.12
• Product Categories: Other fluorin-contained compounds;Aromatic Ethers;Anisole;Miscellaneous;Ethers;Organic Building Blocks;Oxygen Compounds
• Mol File: 93343-10-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 145-148°C
• Flash Point: 111 °F
• Appearance: Clear colorless/Liquid
• Density: 1.234 g/mL at 25 °C(lit.)
• Vapor Pressure: 21.5mmHg at 25°C
• Refractive Index: n20/D 1.466(lit.)
• Storage Temp.: Flammables area
• BRN: 4966844
• CAS DataBase Reference: 3,5-Difluoroanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Difluoroanisole(93343-10-3)
• EPA Substance Registry System: 3,5-Difluoroanisole(93343-10-3)

Safety Data

• Hazard Codes: Xi,F
• Statements: 10-36/37/38
• Safety Statements: 16-26-36/37/39-7/9
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 93343-10-3(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

General Description

The structure and vibrations of 3,5-difluoroanisole in first electronically excited state were studied by mass-analyzed resonant two-photon ionization technique as well as the quantum chemical calculations.

InChI:InChI=1/C7H6F2O/c1-10-7-3-5(8)2-6(9)4-7/h2-4H,1H3

Upstream product

• 325143-04-2 4,4,5,5-tetramethyl-2-(2,4,6-trifluorophenyl)-1,3,2-dioxaborolane 
• 1111096-19-5 2-(2,6-difluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 406482-20-0 (2,6-difluoro-4-methoxyphenyl)boronic acid 
• 2713-34-0 3,5-difluorophenol 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 363-81-5 2,4,6-trifluoroaniline 
• 372-38-3 1,3,5-trifluorobenzene 
• 865-33-8 potassium methanolate 
• 123843-65-2 2,6-difluoro-4-methoxybenzoic acid 

Downstream Products

• 608515-57-7 2,4-difluoro-6-methoxybenzaldehyde 
• 256417-10-4 2,6-difluoro-4-methoxybenzaldehyde 
• 1026308-92-8 1-(2,6-difluoro-4-methoxyphenyl)-2-phenylethanone 
• 125369-56-4 2,6-difluoro-4-methoxybenzoyl chloride 
• 151414-47-0 2,6-difluoro-4-methoxybenzenamine 
• 125369-57-5 2,6-difluoro-4-methoxybenzamide 
• 123843-66-3 2,6-Difluoro-4-methoxybenzonitrile 
• 880885-41-6 2-amino-6-(2-ethoxymethyl-2H-pyrazol-3-yl)-4-methoxy-benzonitrile 
• 880885-38-1 2-amino-6-(4-chloro-pyrazol-1-yl)-4-methoxy-benzonitrile 
• 880885-40-5 2-amino-4-methoxy-6-(2-methyl-2H-pyrazol-3-yl)-benzonitrile 
• 880885-39-2 2-amino-4-methoxy-6-(3-methyl-pyrazol-1-yl)-benzonitrile 
• 880885-42-7 2-amino-4-methoxy-6-thiazol-2-yl-benzonitrile 
• 880885-37-0 2-amino-4-methoxy-6-pyrazol-1-yl-benzonitrile 
• 601516-61-4 2-amino-6-iodo-4-methoxy-benzonitrile 

Relevant articles and documents

Protodeboronation of (Hetero)Arylboronic Esters: Direct versus Prehydrolytic Pathways and Self-/Auto-Catalysis

The kinetics and mechanism of the base-catalyzed hydrolysis (ArB(OR)2→ ArB(OH)2) and protodeboronation (ArB(OR)2→ ArH) of a series of boronic esters, encompassing eight different polyols and 10 polyfluoroaryl and heteroaryl moieties, have been investigated by in situ and stopped-flow NMR spectroscopy (19F,1H, and11B), pH-rate dependence, isotope entrainment,2H KIEs, and KS-DFT computations. The study reveals the phenomenological stability of boronic esters under basic aqueous-organic conditions to be highly nuanced. In contrast to common assumption, esterification does not necessarily impart greater stability compared to the corresponding boronic acid. Moreover, hydrolysis of the ester to the boronic acid can be a dominant component of the overall protodeboronation process, augmented by self-, auto-, and oxidative (phenolic) catalysis when the pH is close to the pKaof the boronic acid/ester.

IMIDAZOPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER

A compound of Formula (IA), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein A, R3, R4, R6, and R7 are as defined herein.

Rh(I)-catalyzed decarboxylative transformations of arenecarboxylic acids: Ligand- and reagent-controlled selectivity toward hydrodecarboxylation or heck-mizoroki products

(Chemical Equetion Presentation) A Rh(I)-based catalyst system has been developed to promote three types of decarboxylative transformations of arenecarboxylic acids: (1) hydrodecarboxylation, (2) Heck-Mizoroki olefination, and (3) conjugate addition. Scopes of reactions (1) and (2) were studied, and the ligand and reagent dependence of selectivity was explored.