- Synthesis of cyanofuroxans from 4-nitrofuroxans via C–C bond forming reactions
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A substitution reaction of 4-nitrofuroxans to prepare 4-cyanofuroxans is described. This substitution reaction was complicated by the reverse reaction and a judicious choice of cyanide source was important to enable this direct synthesis process. The optimized reaction conditions showed an excellent applicability for the synthesis of a range of 4-cyanofuroxans. 3-Cyanofuroxans, known to be thiol-mediated nitric oxide donors, could also be obtained by the thermal or photochemical isomerization of 4-cyanofuroxans. The developed cyanation of furoxans is a rare example of C–C bond-forming reaction on a furoxan ring.
- Matsubara, Ryosuke,Ando, Akihiro,Hayashi, Masahiko
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supporting information
p. 3337 - 3340
(2017/08/03)
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- Synthesis of oxadiazole-2-oxide analogues as potential antischistosomal agents
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The synthesis of several 1,2,5-oxadiazole-2-oxide (Furoxan) analogues is described herein. These compounds were prepared in an effort to probe the SAR around the phenyl substituent and oxadiazole core for our studies toward thioredoxin-glutathione reductase (TGR) inhibition and antischistosomal activity.
- Rai, Ganesha,Thomas, Craig J.,Leister, William,Maloney, David J.
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scheme or table
p. 1710 - 1713
(2009/07/05)
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- Characterisation of furoxancarbonitriles as a new class of vasodilators
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The synthesis, structural characterization, NO-donor properties, and in vitro vasodilating activities of a series of furoxancarbonitriles 2, 17-22a, b are reported. Some derivatives (2b, 2a, 18b, 21b, 22b) are more potent vasodilating agents than sodium n
- Gasco, Andre A Marcello,Boschi, Donatella,Stilo, Antonella Di,Medana, Claudio,Gasco, Alberto,Martorana, Piero Antonio,Schoenafinger, Karl
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p. 212 - 218
(2007/10/03)
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- Phenylfuroxancarboxylic Acids and Their Derivatives
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Synthesis and structure of the two isomeric furoxanecarboxylic acids 3 and 14 and a few of their derivatives 10-13, 15, 16 is reported. 1,3-dipolar cycloaddition reactions of the product obtained by thermal decomposition of 4-phenyl-3-furoxancarboxylic acid and thermal equilibration of furoxan derivatives are also discussed.
- Fruttero, Roberta,Ferrarotti, Bruno,Serafino, Anna,Gasco, Alberto
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p. 335 - 338
(2007/10/02)
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