Glutathione potentiates cGMP synthesis induced by the two phenylfuroxancarbonitrile isomers in RFL-6 cells
The cellular mechanism of bioactivation underlying guanylate cyclase activation by the pair of phenylfuroxancarbonitrile isomers 2a, b was investigated. In cultured rat lung fibroblast (RFL-6 cells) it was principally dependent on intracellular thiols.
Synthesis of oxadiazole-2-oxide analogues as potential antischistosomal agents
The synthesis of several 1,2,5-oxadiazole-2-oxide (Furoxan) analogues is described herein. These compounds were prepared in an effort to probe the SAR around the phenyl substituent and oxadiazole core for our studies toward thioredoxin-glutathione reductase (TGR) inhibition and antischistosomal activity.
Rai, Ganesha,Thomas, Craig J.,Leister, William,Maloney, David J.
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p. 1710 - 1713
(2009/07/05)
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