A simple and convenient one-pot method for the preparation of heteroaryl-2-imidazoles from nitriles
A simple, convenient and high-yielding one-pot method for the synthesis of 2-heterocycle-substituted imidazoles from the corresponding nitriles has been developed. The procedure is easily scaleable and the workup does not involve chromatography. This synthesis is also applicable to the preparation of imidazoles with electron-poor aryl substituents.
Voss, Matthew E.,Beer, Catherine M.,Mitchell, Scott A.,Blomgren, Peter A.,Zhichkin, Paul E.
p. 645 - 651
(2008/04/12)
Synthesis and Cardiac Electrophysiological Activity of N-Substituted-4-(1H-imidazol-1-yl)benzamides-New Selective Class III Agents
The synthesis and cardiac electrophysiological activity of 18 N-substituted imidazolylbenzamides or benzenesulfonamides are described.Compounds 6a,d,f-k and 11 exhibited potency in the in vitro Purkinje fiber assay comparable to that of N-2-(diethylamino
Morgan, Thomas K.,Lis, Randall,Lumma, William C.,Nickisch, Klaus,Wohl, Ronald A.,et al.
p. 1091 - 1097
(2007/10/02)
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