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1260092-44-1

t-Boc-N-amido-PEG1-acid is a PEG-based molecule featuring a terminal carboxylic acid and a Boc-protected amino group. The hydrophilic PEG spacer enhances solubility in aqueous environments, while the terminal carboxylic acid allows for the formation of stable amide bonds with primary amine groups through activation by reagents such as EDC or HATU. The Boc group can be removed under mild acidic conditions to reveal the free amine.

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  • 1260092-44-1 Structure

  • Basic information

    1. Product Name: t-Boc-N-amido-PEG1-acid
    2. Synonyms: t-Boc-N-amido-PEG1-acid;Boc-N-amido-PEG1-acid;t-boc-N-amido-PEG1-propionic acid;Boc-NH-PEG1-CH2CH2COOH;3-[2-(Boc-amino)ethoxy]propanoic acid;3-(2-T-BOC-AMINOETHOXY)PROPANOIC ACID;Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-
    3. CAS NO:1260092-44-1
    4. Molecular Formula: C10H19NO5
    5. Molecular Weight: 233.26
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1260092-44-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 385.0±27.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.127±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 4.29±0.10(Predicted)
    10. CAS DataBase Reference: t-Boc-N-amido-PEG1-acid(CAS DataBase Reference)
    11. NIST Chemistry Reference: t-Boc-N-amido-PEG1-acid(1260092-44-1)
    12. EPA Substance Registry System: t-Boc-N-amido-PEG1-acid(1260092-44-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1260092-44-1(Hazardous Substances Data)

1260092-44-1 Usage

Uses

Used in Pharmaceutical Industry:
t-Boc-N-amido-PEG1-acid is used as a PEGylation agent for improving the solubility, stability, and bioavailability of therapeutic agents. The Boc-protected amino group enables selective deprotection and subsequent conjugation to target molecules, facilitating the development of PEGylated drugs with enhanced pharmacokinetic properties.
Used in Bioconjugation:
t-Boc-N-amido-PEG1-acid is used as a bioconjugation reagent for attaching biologically active molecules to other biomolecules or surfaces. The terminal carboxylic acid allows for the formation of stable amide bonds with primary amine groups, enabling the creation of conjugates with precise control over the molecular structure and properties.
Used in Drug Delivery Systems:
t-Boc-N-amido-PEG1-acid is used as a component in the design of drug delivery systems, such as nanoparticles or hydrogels, for targeted and controlled drug release. The PEG spacer and terminal carboxylic acid facilitate the attachment of drug molecules or other functional groups, enhancing the performance and biocompatibility of the delivery system.
Used in Diagnostics and Imaging:
t-Boc-N-amido-PEG1-acid is used as a molecular probe for diagnostic and imaging applications. The PEG spacer and terminal carboxylic acid can be functionalized with imaging agents or targeting ligands, allowing for the development of contrast agents or probes for molecular imaging techniques such as MRI, PET, or fluorescence imaging.

Check Digit Verification of cas no

The CAS Registry Mumber 1260092-44-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,0,0,9 and 2 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1260092-44:
(9*1)+(8*2)+(7*6)+(6*0)+(5*0)+(4*9)+(3*2)+(2*4)+(1*4)=121
121 % 10 = 1
So 1260092-44-1 is a valid CAS Registry Number.

1260092-44-1Downstream Products

1260092-44-1Relevant articles and documents

Poly(vinyl ester) Polymers for In Vivo Nucleic Acid Delivery

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Paragraph 0171, (2015/10/28)

The present invention is directed membrane active poly(vinyl ester) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cells in vivo. RNAi polynucleotides are conjugated to the poly(vinyl ester) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(vinyl ester) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.

Poly(vinyl ester) Polymers for In Vivo Nucleic Acid Delivery

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Paragraph 0174, (2013/05/22)

The present invention is directed membrane active poly(vinyl ester) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cells in vivo. RNAi polynucleotides are conjugated to the poly(vinyl ester) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(vinyl ester) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.

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