Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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Page/Page column 291
(2019/05/22)
MODULATORS OF THE INTEGRATED STRESS PATHWAY
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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Page/Page column 357
(2017/12/15)
Optimization of non-ATP competitive CDK/cyclin groove inhibitors through REPLACE-mediated fragment assembly
A major challenge in drug discovery is to develop and improve methods for targeting protein-protein interactions. Further exemplification of the REPLACE (REplacement with Partial Ligand Alternatives through Computational Enrichment) strategy for generatin
Functionalized 4-aminoquinolines by rearrangement of pyrazole N-heterocyclic carbenes
(Figure Presented) Thermal decarboxylation of 1-phenyl pyrazolium-3- carboxylates from the mesomeric betaine class of substances leads to pyrazole-N-heterocyclic carbenes, which immediately rearrange to multiply substituted 4-aminoquinolines (see scheme). These species are of interest for the synthesis of heterocycles and pharmacologically active compounds.
Schmidt, Andreas,Muenster, Niels,Dreger, Andrij
supporting information; experimental part
p. 2790 - 2793
(2010/07/04)
Pyrazole-amides and sulfonamides as sodium channel modulators
Compounds of the present invention modulate PN3 in mammals and are useful in treating pain in mammals.
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Page/Page column 15
(2010/02/10)
Pyrazole-amides and sulfonamides as sodium channel modulators
Compounds of the present invention modulate PN3 in mammals and are useful in treating pain in mammals.
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Page 16
(2010/02/09)
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