126067-52-5Relevant articles and documents
MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Page/Page column 291, (2019/05/22)
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Page/Page column 357, (2017/12/15)
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
Optimization of non-ATP competitive CDK/cyclin groove inhibitors through REPLACE-mediated fragment assembly
Liu, Shu,Premnath, Padmavathy Nandha,Bolger, Joshua K.,Perkins, Tracy L.,Kirkland, Lindsay O.,Kontopidis, George,McInnes, Campbell
, p. 1573 - 1582 (2013/04/10)
A major challenge in drug discovery is to develop and improve methods for targeting protein-protein interactions. Further exemplification of the REPLACE (REplacement with Partial Ligand Alternatives through Computational Enrichment) strategy for generatin
Functionalized 4-aminoquinolines by rearrangement of pyrazole N-heterocyclic carbenes
Schmidt, Andreas,Muenster, Niels,Dreger, Andrij
supporting information; experimental part, p. 2790 - 2793 (2010/07/04)
(Figure Presented) Thermal decarboxylation of 1-phenyl pyrazolium-3- carboxylates from the mesomeric betaine class of substances leads to pyrazole-N-heterocyclic carbenes, which immediately rearrange to multiply substituted 4-aminoquinolines (see scheme). These species are of interest for the synthesis of heterocycles and pharmacologically active compounds.
Pyrazole-amides and sulfonamides as sodium channel modulators
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Page/Page column 15, (2010/02/10)
Compounds of the present invention modulate PN3 in mammals and are useful in treating pain in mammals.
Pyrazole-amides and sulfonamides as sodium channel modulators
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Page 16, (2010/02/09)
Compounds of the present invention modulate PN3 in mammals and are useful in treating pain in mammals.