126443-07-0Relevant articles and documents
Iodine-Promoted Semmler–Wolff Reactions: Step-Economic Access to meta-Substituted Primary Anilines via Aromatization
Wang, Shi-Ke,You, Xia,Zhao, Da-Yuan,Mou, Neng-Jie,Luo, Qun-Li
, p. 11757 - 11760 (2017/09/07)
An atom- and step-economic access to an array of unprotected meta-substituted primary anilines was disclosed using the Semmler–Wolff reaction, promoted by molecular iodine. Therein, noble metal catalysts and inert atmosphere are unnecessary while the forcing reaction conditions and the lengthy synthesis can be avoided. The synthetic utility of this approach is evident in the de novo syntheses of three bioactive molecules with good total yields.
Copper-catalyzed oxidative coupling of alkenes with aldehydes: Direct access to α,β-unsaturated ketones
Wang, Jing,Liu, Chao,Yuan, Jiwen,Lei, Aiwen
supporting information, p. 2256 - 2259 (2013/04/10)
Let's get radical: The first copper-catalyzed oxidative coupling of alkenes and aldehydes was developed. Various aldehydes were utilized as substrates to construct α,β-unsaturated ketones. A preliminary mechanistic study indicated that this reaction is likely to proceed through a single-electron transfer. Copyright
A new and direct synthesis of chalcones via TFAA-H3PO 4 mediated c-c bond forming reaction
Kankanala, Kavitha,Reddy, Lingam Venkata,Reddy, Vangala Ranga,Mukkantia, Khagga,Pal, Sarbani
experimental part, p. 53 - 59 (2012/04/18)
A number of α,β-unsaturated carboxylic acids were reacted with electron rich arenes or heteroarene in the presence of trifluoroacetic anhydride (TFAA) and H3PO4 at room temperature to give a variety of chalcone derivatives in good to
Synthesis of some new pyrazolines and isoxazoles carrying 4-methylthiophenyl moiety as potential analgesic and antiinflammatory agents
Karabasanagouda,Adhikari, Airody Vasudeva,Girisha
experimental part, p. 430 - 437 (2009/12/26)
A series of new pyrazolines 3a-m and isoxazoies 4a-k have been synthesized from 4-acetylthioanisole, 1 with aryl aldehydes through α, β-unsaturated ketones. The structures of the newly synthesized compounds have been confirmed on the basis of elemental analysis and spectral studies. The newly synthesized title compounds have been tested for their analgesic and antiinflammatory activity. Some of the compounds exhibited encouraging results.