126614-04-8Relevant academic research and scientific papers
Synthesis of Quaternary Amine Ether Lipids and Evaluation of Neoplastic Cell Growth Inhibitory Properties
Morris-Natschke, Susan L.,Meyer, Karen L.,Marasco, Canio J.,Piantadosi, Claude,Rossi, Fiona,et al.
, p. 1812 - 1818 (1990)
Novel quaternary amine ether lipids have been synthesized and tested for inhibition of neoplastic cell proliferation with the HL-60 promyelocytic leukemia cell line.The compounds contain a positively charged quaternary amine functional group attached either directly to the glycerol backbone or at the end of an alkoxy chain.The biological testing has identified several analogues with activity equivalent to greater than that exhibited by the reference compound in this assay, ET-18-OMe (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine).Among the most active analogues are compounds 11, and 22 -1-butyl>pyridinium bromide>, which are approximately 3 times as active as the reference standard.
Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions
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, (2008/06/13)
Quaternary amine-containing ether lipid analogs of the formula are disclosed. R1 represents a hydrophobic group and R2 represents the backbone of the molecule, with the quaternary amine being linked directly to the backbone. Pharmaceutical compositions including these compounds and methods of combating tumors with these compounds are disclosed. Also disclosed is a method of combating viral infections with both these compounds and ET-18-OMe and its analogs.
