Synthesis of Quaternary Amine Ether Lipids and Evaluation of Neoplastic Cell Growth Inhibitory Properties

Article abstract of DOI:10.1021/jm00168a042

Novel quaternary amine ether lipids have been synthesized and tested for inhibition of neoplastic cell proliferation with the HL-60 promyelocytic leukemia cell line.The compounds contain a positively charged quaternary amine functional group attached either directly to the glycerol backbone or at the end of an alkoxy chain.The biological testing has identified several analogues with activity equivalent to greater than that exhibited by the reference compound in this assay, ET-18-OMe (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine).Among the most active analogues are compounds 11, and 22 -1-butyl>pyridinium bromide>, which are approximately 3 times as active as the reference standard.