126918-27-2

Basic information

• Product Name: [(2R,3S)-2-(2,4-DIFLUORO-PHENYL)-3-METHYL-OXIRANYL]-METHANOL
• Synonyms: [(2R,3S)-2-(2,4-DIFLUORO-PHENYL)-3-METHYL-OXIRANYL]-METHANOL
• CAS NO: 126918-27-2
• Molecular Formula: C₁₀H₁₀F₂O₂
• Molecular Weight: 200.1820064
• Mol File: 126918-27-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [(2R,3S)-2-(2,4-DIFLUORO-PHENYL)-3-METHYL-OXIRANYL]-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [(2R,3S)-2-(2,4-DIFLUORO-PHENYL)-3-METHYL-OXIRANYL]-METHANOL(126918-27-2)
• EPA Substance Registry System: [(2R,3S)-2-(2,4-DIFLUORO-PHENYL)-3-METHYL-OXIRANYL]-METHANOL(126918-27-2)

Safety Data

• Hazardous Substances Data: 126918-27-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
[(2R,3S)-2-(2,4-DIFLUORO-PHENYL)-3-METHYL-OXIRANYL]-METHANOL is used as a potential active pharmaceutical ingredient (API) for its unique structural features, which may offer novel therapeutic benefits in the treatment of various diseases.
Used in Agricultural Industry:
In the agricultural sector, [(2R,3S)-2-(2,4-DIFLUORO-PHENYL)-3-METHYL-OXIRANYL]-METHANOL could be utilized as a component in the development of new pesticides or herbicides, leveraging its specific chemical properties to target and control pests and weeds more effectively.
Used in Material Science:
Within the field of material science, [(2R,3S)-2-(2,4-DIFLUORO-PHENYL)-3-METHYL-OXIRANYL]-METHANOL may serve as a key building block for the synthesis of advanced materials with tailored properties, such as improved mechanical strength, thermal stability, or chemical resistance.

Upstream product

• 126918-26-1 (2S,3S)-2-(2,4-Difluorophenyl)-2,3-epoxybutanal 
• 126917-43-9 (R)-(2,4-difluorophenyl) 1-chloroethyl ketone 
• 126917-44-0 (R)-3-chloro-2-(2,4-difluorophenyl)-1-butene 
• 126917-45-1 (2R,3R)-3-Chloro-2-(2,4-difluorophenyl)-1,2-butanediol 

Downstream Products

• 124627-86-7 1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole 

Relevant articles and documents

Concise Synthesis of Optically Active Oxirane Precursors for the Preparation of Triazole Antifungals Using the Friedel-Crafts Reaction of (S)-2-Tosyloxypropionyl Chloride

Optically active epoxide (2R,3S)-4, a key intermediate for the preparation of triazole antifungal agents (4R,5R)-1 and (2R,3R)-2 (X = 2,4-F2), was synthesized.The Friedel-Crafts reaction between the (S)-lactic acid derivative (S)-10 and m-difluorobenzene gave the (R)-2-chloropropiophenone derivative (R)-11, which was converted into (2R,3R)-18 via Peterson olefination, stereoselective osmium(VIII) oxide oxidation, and mesylation.Treatment of (2R,3R)-18 with sodium triazolide gave (2R,3S)-4.Similarly, the 4-chlorophenyl analog (2R,3S)-4' was prepared.

Triazole derivatives, their preparation and their use as fungicides

Compounds of formula (I): in which: Ar is optionally substituted phenyl; R1 is hydrogen or alkyl; X is optionally unsaturated alkylene, cycloalkylene or both; mis 0 or 1; -Yn-R2 is azido, phthalimido, 1-oxo-2,3-dihydro-2-isoindolyl, protected hydroxy or -OSO2R4 (in which R4 is alkyl group, haloalkyl or optionally substituted phenyl); or Y represents a group of formula -N(R5)CO-, -N(R5)CO-CH=CH-, -O-CO-, -O-CO-CH=CH-, -S-CO- or -S-CO-CH=CH- (in which R5 is hydrogen or alkyl); nis 0 or 1; R2 is alkyl, haloalkyl or optionally substituted phenyl, naphthyl or heterocyclic; and R3 is hydrogen; or R3 and -Xm-Yn-R2 together are a group of formula (II): in which R2 is as defined above, pis 0 or 1, and qis 0 or 1;, and acid addition salts thereof are fungicides, which find considerable value in the eradication of fungi in both agriculture and medicine.