126917-43-9

Basic information

• Product Name: (R)-2-CHLORO-1-(2,4-DIFLUORO-PHENYL)-PROPAN-1-ONE
• Synonyms: (R)-2-CHLORO-1-(2,4-DIFLUORO-PHENYL)-PROPAN-1-ONE;1-Propanone, 2-chloro-1-(2,4-difluorophenyl)-, (R)- (9CI)
• CAS NO: 126917-43-9
• Molecular Formula: C₉H₇ClF₂O
• Molecular Weight: 204.6010864
• Product Categories: ACETYLHALIDE
• Mol File: 126917-43-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-2-CHLORO-1-(2,4-DIFLUORO-PHENYL)-PROPAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-CHLORO-1-(2,4-DIFLUORO-PHENYL)-PROPAN-1-ONE(126917-43-9)
• EPA Substance Registry System: (R)-2-CHLORO-1-(2,4-DIFLUORO-PHENYL)-PROPAN-1-ONE(126917-43-9)

Safety Data

• Hazardous Substances Data: 126917-43-9(Hazardous Substances Data)

Usage

General Description

"(R)-2-CHLORO-1-(2,4-DIFLUORO-PHENYL)-PROPAN-1-ONE" is a chemical compound with a molecular formula C9H8ClF2O. It is a chiral compound, meaning it has a non-superimposable mirror image. (R)-2-CHLORO-1-(2,4-DIFLUORO-PHENYL)-PROPAN-1-ONE is a ketone, which is a functional group characterized by a carbonyl group bonded to two carbon atoms. The presence of a chloro group and two difluoro groups in the chemical structure gives it certain properties and potential applications in organic synthesis and pharmaceutical research. Additionally, its chiral nature may make it useful for the development of new chiral catalysts or pharmaceuticals.

Upstream product

• 79-37-8 oxalyl dichloride 
• 372-18-9 1,3-Difluorobenzene 
• 70836-98-5 (S)-2-(p-toluenesulphonyloxy)propionic acid 
• 83261-13-6 (2S)-2-(4-toluenesulfonyloxy)propionyl chloride 
• 126918-15-8 (S)-2-(p-toluenesulfonyloxy)-2',4'-difluoropropiophenone 
• 7623-09-8 2-chloropropionyl chloride 
• 126918-14-7 (2S)-2',4'-Difluoro-2-hydroxypropiophenone 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 139330-84-0 (S)-2-((R)-1-Chloro-ethyl)-2-(2,4-difluoro-phenyl)-oxirane 
• 740832-68-2 1-(2,4-difluorophenyl)-2-(5-{2-[4-phenyl-piperazin-1-yl]ethyl}tetrazol-1-yl)propan-1-one 
• 740832-40-0 1-(2,4-difluorophenyl)-2-(5-{2-[4-phenyl-piperazin-1-yl]ethyl}tetrazol-2-yl)propan-1-one 
• 359826-10-1 2-{4-[4-[4-(2-methyl-5-chlorophenyl)piperazinyl]phenyl]-(2H,4H)-1,2,4-triazol-3-one-2-yl}-2(R/S)-methyl-2,4-difluoroacetophenone 
• 740832-38-6 1-(2,4-difluorophenyl)-2-(5-{2-[4-(2-n-butoxyphenyl)piperazin-1-yl]ethyl}tetrazol-2-yl)propan-1-one 
• 740832-66-0 1-(2,4-difluorophenyl)-2-(5-{2-[4-(2-n-butoxyphenyl)piperazin-1-yl]ethyl}tetrazol-1-yl)propan-1-one 
• 740832-48-8 1-(2,4-difluorophenyl)-2-(5-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}tetrazol-1-yl)propan-1-one 
• 740832-20-6 1-(2,4-difluorophenyl)-2-(5-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}tetrazol-2-yl)propan-1-one 
• 740832-64-8 1-(2,4-difluorophenyl)-2-(5-{2-[4-(diphenylmethyl)piperazin-1-yl]ethyl}tetrazol-1-yl)propan-1-one 
• 740832-36-4 1-(2,4-difluorophenyl)-2-(5-{2-[4-(diphenylmethyl)piperazin-1-yl]ethyl}tetrazol-2-yl)propan-1-one 
• 740832-60-4 1-(2,4-difluorophenyl)-2-(5-{2-[4-(2,4-dichlorophenyl)piperazin-1-yl]ethyl}tetrazol-1-yl)propan-1-one 
• 740832-32-0 1-(2,4-difluorophenyl)-2-(5-{2-[4-(2,4-dichlorophenyl)piperazin-1-yl]ethyl}tetrazol-2-yl)propan-1-one 
• 740832-18-2 1-(2,4-difluorophenyl)-2-(5-{2-[4-(4-nitrophenyl)piperazin-1-yl]ethyl}tetrazol-2-yl)propan-1-one 
• 740832-46-6 1-(2,4-difluorophenyl)-2-(5-{2-[4-(4-nitrophenyl)piperazin-1-yl]ethyl}tetrazol-1-yl)propan-1-one 

Relevant articles and documents

Synthesis and biological evaluation of vinyl ether-containing azole derivatives as inhibitors of Trichophyton rubrum

In an attempt to search for many target compounds with excellent activities, a series of vinyl ether-containing azole derivatives were designed, synthesized, and evaluated as antifungal agents. Results of preliminary antifungal tests against Trichophyton rubrum in vitro indicated that most of the synthesized compounds showed excellent activities. In comparison with fluconazole, itraconazole, voriconazole, omoconazole and amphotericin B, several compounds (such as 7d, 7g and 7h) exhibited more potent inhibitory activities, suggesting that they were promising leads for the development of novel antifungal agents.

Azole compounds as therapeutic agents for fungal infections

The present invention relates to the derivatives of specially substituted azole compounds which have improved antifungal activity as compared to known compounds such as fluconazole and itraconazole and the processes for the preparation thereof. This invention also relates to pharmaceutical compositions containing the compounds of the present invention and their use in treating and/or preventing fungal infections in mammals, preferably humans.

Concise Synthesis of Optically Active Oxirane Precursors for the Preparation of Triazole Antifungals Using the Friedel-Crafts Reaction of (S)-2-Tosyloxypropionyl Chloride

Optically active epoxide (2R,3S)-4, a key intermediate for the preparation of triazole antifungal agents (4R,5R)-1 and (2R,3R)-2 (X = 2,4-F2), was synthesized.The Friedel-Crafts reaction between the (S)-lactic acid derivative (S)-10 and m-difluorobenzene gave the (R)-2-chloropropiophenone derivative (R)-11, which was converted into (2R,3R)-18 via Peterson olefination, stereoselective osmium(VIII) oxide oxidation, and mesylation.Treatment of (2R,3R)-18 with sodium triazolide gave (2R,3S)-4.Similarly, the 4-chlorophenyl analog (2R,3S)-4' was prepared.