As easy as ABCD: (-)-Jiadifenin was synthesized in eighteen reaction steps from 1-[(E)-(4′-bromo-2′-butenyl)oxy]-4-methoxybenzene. Key features of this synthesis include: 1) Ireland-Claisen rearrangement to produce the two contiguous quaternary centers at
A Selective Baeyer-Villiger Oxidation: A Total Synthesis of (-)-Acetomycin
A short, stereoselective synthesis of (-)-acetomycin (2) from L-threonine is reported.The final step in the synthesis is a selective Baeyer-Villiger oxidation that discriminates between two methyl ketones.
Ziegler, Frederick E.,Kim, Hakwon
p. 7669 - 7672
(2007/10/02)
ENZYMATIC ENANTIOSELECTIVE HYDROLYSIS OF 2,2-DIMETHYL-1,3-DIOXOLANE-4-CARBOXYLIC ESTERS
2,2-dimethyl-1,3-dioxolane-4-carboxylic acid derived chiral building blocks were prepared from substituted α,β-unsaturated acids with high enantiomeric purities by enzymatic hydrolysis of their n.butyl esters.
Pottie, M.,Eycken, J. Van der,Vandewalle, M.,Dewanckele, J. M.,Roeper, H.
p. 5319 - 5322
(2007/10/02)
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