1273587-21-5

Basic information

• Product Name: ethyl 2-(4-cyanophenyl)-2-methylpropanoate
• Synonyms: ethyl 2-(4-cyanophenyl)-2-methylpropanoate
• CAS NO: 1273587-21-5
• Molecular Weight: 217.268
• Mol File: 1273587-21-5.mol

Chemical Properties

• CAS DataBase Reference: ethyl 2-(4-cyanophenyl)-2-methylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-cyanophenyl)-2-methylpropanoate(1273587-21-5)
• EPA Substance Registry System: ethyl 2-(4-cyanophenyl)-2-methylpropanoate(1273587-21-5)

Safety Data

• Hazardous Substances Data: 1273587-21-5(Hazardous Substances Data)

Upstream product

• 623-00-7 4-bromobenzenecarbonitrile 
• 97-62-1 Ethyl isobutyrate 
• 1528-41-2 ethyl 4-cyanophenylacetate 
• 74-88-4 methyl iodide 

Downstream Products

• 1415501-03-9 ethyl 2-[4-(aminomethyl)phenyl]-2-methylpropanoate hydrochloride 

Relevant articles and documents

POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4

Disclosed herein are tricyclic compounds, including pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine-8-amine, pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine-4-amine, pyrazino[2′,3′:4,5]thieno[3,2-d]pyrimidin-4-amine, pyrido[3′,2′:4,5]furo[3, 2-d]pyrimidin-4-amine, and pyrimido[4′,5′:4,5]furo[2,3-c]pyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

IMIDAZOPYRIDINE COMPOUNDS

[Problem] An excellent drug for treating or preventing cardiovascular diseases, based on cGMP production enhancing action due to soluble guanylate cyclase activating action, is provided. [Means for Solution] It was found that imidazopyridine compounds having a carbamoyl group at the 3-position and a substituent bonded at the 8-position via an oxygen atom in an imidazo[1,2-a]pyridine skeleton exhibits a cGMP production enhancing action by a potent soluble guanylate cyclase activating action, and is useful as a drug for treating or preventing various soluble guanylate cyclase-related cardiovascular diseases, thereby completing the present invention.

Pd-catalyzed α-arylation of nitriles and esters and γ-arylation of unsaturated nitriles with TMPZnCl?LiCl

Using TMPZnCl?LiCl as a kinetically highly active base, nitriles and esters undergo a Pd-catalyzed α-arylation under mild conditions. Remarkably, in the case of α,β- or β,γ-unsaturated nitriles, a regioselective γ-arylation or a γ-alkenylation is observed.