1528-41-2

Basic information

• Product Name: ethyl 2-(4-cyanophenyl)acetate
• Synonyms: Ethyl 4-cyanophenylacetate, 98%;p-Cyanophenyl acetic acid ethyl ester;4-Cyanobenzeneacetic acid ethyl ester;NSC 130982;Benzeneacetic acid, 4-cyano-, ethyl ester;Ethyl 2-(4-cyanophenyl);ethyl 2-(4-cyanophenyl)acetate;4-Cyanophenylacetic acid ethyl ester
• CAS NO: 1528-41-2
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.2105
• Mol File: 1528-41-2.mol
• Article Data: 25

Chemical Properties

• Melting Point: 90-94°C
• Boiling Point: 305℃
• Flash Point: 141℃
• Appearance: white powder
• Density: 1.11
• Vapor Pressure: 0.000858mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: ethyl 2-(4-cyanophenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-cyanophenyl)acetate(1528-41-2)
• EPA Substance Registry System: ethyl 2-(4-cyanophenyl)acetate(1528-41-2)

Safety Data

• RIDADR: UN3439
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 1528-41-2(Hazardous Substances Data)

Usage

General Description

Ethyl 2-(4-cyanophenyl)acetate is a chemical compound with the molecular formula C11H11NO2. It is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. ethyl 2-(4-cyanophenyl)acetate is a clear, colorless liquid with a fruity odor, and it is soluble in organic solvents such as ethanol and ether. Ethyl 2-(4-cyanophenyl)acetate is primarily used as a flavoring agent and fragrance in cosmetic and personal care products. Additionally, it has been studied for its potential therapeutic properties, including antimicrobial and anti-inflammatory effects. However, it is important to handle this chemical with care, as it can be hazardous if not used properly.

InChI:InChI=1/C11H11NO2/c1-2-14-11(13)7-9-3-5-10(8-12)6-4-9/h3-6H,2,7H2,1H3

Upstream product

• 623-00-7 4-bromobenzenecarbonitrile 
• 681-94-7 ethyl 2-(tributylstannyl)acetate 
• 14062-25-0 Ethyl 4-bromophenylacetate 
• 143-33-9 sodium cyanide 
• 557-21-1 zinc(II) cyanide 
• 623-33-6 glycine ethyl ester hydrochloride 
• 126747-14-6 4-cyanophenylboronic acid 
• 3058-39-7 4-iodobenzonitrile 
• 2678-54-8 ketene diethyl acetal 
• 773837-37-9 sodium cyanide 
• 557-21-1 dicyanozinc 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 6148-64-7 ethyl potassium malonate 
• 105-53-3 diethyl malonate 

Downstream Products

• 62910-17-2 4-(5-chloro-2-methoxybenzamidomethyl)-phenylacetic acid 
• 42383-05-1 2-(4-(aminomethyl)phenyl)acetic acid hydrochloride 
• 62910-19-4 4-(2-butoxy-5-chlorobenzamidomethyl)-phenylacetic acid 
• 118618-32-9 ethyl 2-(p-cyano-phenyl)-propionate 
• 362052-00-4 2-(4-cyano-phenyl)-propionic acid 
• 1428765-46-1 2-(4-cyanophenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 
• 1428765-47-2 2-(4-(aminomethyl)phenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 
• 1428765-49-4 ethyl 2-(4-((tert-butoxycarbonylamino)methyl)phenyl)propanoate 
• 1428765-50-7 ethyl 2-(4-(aminomethyl)phenyl)propanoate 
• 1428765-51-8 ethyl 2-(4-((N-(tert-butoxycarbonyl)sulfamoylamino)methyl)phenyl)propanoate 
• 1428765-52-9 2-(4-(((N-(tert-butoxycarbonyl)sulfamoyl)amino)methyl)phenyl)propanoic acid 
• 1428765-05-2 2-(4-((sulfamoylamino)methyl)phenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 
• 1428765-48-3 tert-butyl N-(4-(1-oxo-1-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzyl)sulfamoylcarbamate 
• 1449391-43-8 potassium 2-ethoxy-1-(4-cyanophenyl)-2-oxoethan-1-ide 

Relevant articles and documents

Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters

We have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale.

MODULATORS OF EXCITATORY AMINO ACID TRANSPORTERS AND METHODS USING SAME

The present disclosure provides compounds of Formula I useful for treating, ameliorating or preventing a disease or disorder that is caused, induced or characterized by abnormal reduction in glutamate transporter activity or abnormal increase in extracellular CNS glutamate concentration in a subject. In certain embodiments, the compounds of Formula I stimulate a glutamate transporter.

N-Heterocyclic Carbenes as Key Intermediates in the Synthesis of Fused, Mesoionic, Tricyclic Heterocycles

Coupling between 5-bromoimidazo[1,5-a]pyridinium salts and malonate or arylacetate esters leads to a facile and straightforward access to the new mesoionic, fused, tricyclic system of imidazo[2,1,5-cd]indolizinium-3-olate. Mechanistic studies show that the reaction pathway consists of nucleophilic aromatic substitution on the cationic, bicyclic heterocycle by an enolate-type moiety and in the nucleophilic attack of a transient free N-heterocyclic carbene (NHC) species on the ester group; the relative order of these two steps depends on the nature of the starting ester. This work highlights the valuable implementation of free NHC species as key intermediates in synthetic chemistry, beyond their classical use as stabilizing ligands or organocatalysts.