1528-41-2

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 2-(4-cyanophenyl)acetate is utilized as a key intermediate in the synthesis of a range of pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Flavoring and Fragrance Industry:
In the flavoring and fragrance industry, ethyl 2-(4-cyanophenyl)acetate is employed as a flavoring agent and fragrance, enhancing the sensory appeal of cosmetic and personal care products.
Used in Cosmetic and Personal Care Products:
Ethyl 2-(4-cyanophenyl)acetate is used as a flavoring agent and fragrance in cosmetic and personal care products, adding to their sensory characteristics and consumer experience.
Used in Research and Development:
ethyl 2-(4-cyanophenyl)acetate is also studied for its potential therapeutic properties, such as antimicrobial and anti-inflammatory effects, indicating its use in research and development for new applications in medicine and healthcare.
It is crucial to handle ethyl 2-(4-cyanophenyl)acetate with care due to its potential hazards if not used properly, emphasizing the need for safety measures in its application across various industries.

InChI:InChI=1/C11H11NO2/c1-2-14-11(13)7-9-3-5-10(8-12)6-4-9/h3-6H,2,7H2,1H3

Upstream product

• 623-00-7 4-bromobenzenecarbonitrile 
• 141-97-9 ethyl acetoacetate 
• 14062-25-0 Ethyl 4-bromophenylacetate 
• 143-33-9 sodium cyanide 
• 64-17-5 ethanol 
• 5462-71-5 4-cyanophenylacetic acid 
• 623-03-0 4-Cyanochlorobenzene 
• 6148-64-7 ethyl potassium malonate 
• 105-53-3 diethyl malonate 
• 557-21-1 dicyanozinc 
• 3058-39-7 4-iodobenzonitrile 
• 2678-54-8 ketene diethyl acetal 
• 623-33-6 glycine ethyl ester hydrochloride 
• 126747-14-6 4-cyanophenylboronic acid 

Downstream Products

• 62910-48-9 ethyl 2-[4-(aminomethyl)phenyl]acetate 
• 911301-03-6 (E)-2-(4-Cyano-phenyl)-3-furan-2-yl-acrylic acid ethyl ester 
• 911301-04-7 (E)-2-(4-Cyano-phenyl)-3-thiophen-2-yl-acrylic acid ethyl ester 
• 62910-17-2 4-(5-chloro-2-methoxybenzamidomethyl)-phenylacetic acid 
• 42383-05-1 2-(4-(aminomethyl)phenyl)acetic acid hydrochloride 
• 62910-19-4 4-(2-butoxy-5-chlorobenzamidomethyl)-phenylacetic acid 
• 362052-00-4 2-(4-cyano-phenyl)-propionic acid 
• 1428765-46-1 2-(4-cyanophenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 
• 1428765-47-2 2-(4-(aminomethyl)phenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 
• 1428765-49-4 ethyl 2-(4-((tert-butoxycarbonylamino)methyl)phenyl)propanoate 
• 1428765-50-7 ethyl 2-(4-(aminomethyl)phenyl)propanoate 
• 1428765-51-8 ethyl 2-(4-((N-(tert-butoxycarbonyl)sulfamoylamino)methyl)phenyl)propanoate 
• 1428765-52-9 2-(4-(((N-(tert-butoxycarbonyl)sulfamoyl)amino)methyl)phenyl)propanoic acid 
• 1428790-17-3 2-(4-cyanophenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 

Relevant academic research and scientific papers

Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters

We have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale.

MODULATORS OF EXCITATORY AMINO ACID TRANSPORTERS AND METHODS USING SAME

The present disclosure provides compounds of Formula I useful for treating, ameliorating or preventing a disease or disorder that is caused, induced or characterized by abnormal reduction in glutamate transporter activity or abnormal increase in extracellular CNS glutamate concentration in a subject. In certain embodiments, the compounds of Formula I stimulate a glutamate transporter.

Photoinduced Cross-Coupling of Aryl Iodides with Alkenes

A protocol for photoinduced cross-coupling of aryl iodides having polar π-functional groups or elongated π-conjugation with alkenes has been developed. The radical cascade mechanism involving generation of aryl radicals via C-I bond homolysis of photoexcited aryl iodides and their subsequent addition to alkenes is proposed. The method enables iodide-selective cross-coupling over other halogen leaving groups with functional group compatibility on both arene and alkene motifs.

The base-catalysed Tamura cycloaddition reaction: Calculation, mechanism, isolation of intermediates and asymmetric catalysis

A combined experimental and computational investigation has revealed that the base-catalysed Tamura cycloaddition between homophthalic anhydride and activated alkenes/alkynes-a reaction previously thought of as a Diels-Alder type process-proceeds via a stepwise mechanism involving conjugate addition and ring closure; which allowed the first catalytic asymmetric α-substitution reactions to be demonstrated with up to >99% ee.

N-Heterocyclic Carbenes as Key Intermediates in the Synthesis of Fused, Mesoionic, Tricyclic Heterocycles

Coupling between 5-bromoimidazo[1,5-a]pyridinium salts and malonate or arylacetate esters leads to a facile and straightforward access to the new mesoionic, fused, tricyclic system of imidazo[2,1,5-cd]indolizinium-3-olate. Mechanistic studies show that the reaction pathway consists of nucleophilic aromatic substitution on the cationic, bicyclic heterocycle by an enolate-type moiety and in the nucleophilic attack of a transient free N-heterocyclic carbene (NHC) species on the ester group; the relative order of these two steps depends on the nature of the starting ester. This work highlights the valuable implementation of free NHC species as key intermediates in synthetic chemistry, beyond their classical use as stabilizing ligands or organocatalysts.

Catalytic Asymmetric γ-Lactam Synthesis from Enolisable Anhydrides and Imines

An anion-binding approach to the problem of preparing enantioenriched γ-lactams from enolisable anhydrides and imines is reported. A simple bisurea catalyst promotes the cycloaddition between α-aryl succinic anhydrides and either PMP- or benzhydryl-protec

Synthesis of α-aryl esters and nitriles: Deaminative coupling of α-aminoesters and α-aminoacetonitriles with arylboronic acids

Transition-metal-free synthesis of α-aryl esters and nitriles using arylboronic acids with α-aminoesters and α-aminoacetonitriles, respectively, as the starting materials has been developed. The reaction represents a rare case of converting C(sp3)-N bonds into C(sp3)-C(sp2) bonds. The reaction conditions are mild, demonstrate good functional-group tolerance, and can be scaled up. Touch base: A transition-metal-free protocol for the synthesis of α-aryl esters and nitriles by deaminative coupling is presented. Strong bases and transition-metal catalysts are not needed. The new synthetic method uses readily available starting materials and demonstrates wide substrate scope.

6-(5-HYDROXY-1H-PYRAZOL-1-YL)NICOTINAMIDE DERIVATIVES AND THEIR USE AS PHD INHIBITORS

The present invention provides compounds of formula (I) which are useful as inhibitors of PHD, pharmaceutical compositions thereof, methods for treatment of conditions associated with HIF, processes for making the compounds and intermediates thereof.

Aryl or N-heteroaryl Substituted Methanesulfonamide Derivatives as Vanilloid Receptor Ligands

The invention relates to aryl or N-heteroaryl substituted methanesulfonamide derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Amine Substituted Methanesulfonamide Derivatives as Vanilloid Receptor Ligands

The invention relates to amine substituted methanesulfonamide derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.