127399-72-8

Basic information

• Product Name: 5-Benzyloxy-6-methoxy-1-indanone
• Synonyms: 2,3-Dihydro-6-methoxy-5-(phenylmethoxy)-1H-inden-1-one;5-Benzyloxy-6-methoxy-1-indanone
• CAS NO: 127399-72-8
• Molecular Formula: C₁₇H₁₆O₃
• Molecular Weight: 268.31
• Product Categories: Aromatics Compounds;Aromatics;Heterocycles;Aromatics, Heterocycles
• Mol File: 127399-72-8.mol

Chemical Properties

• Appearance: /
• Solubility: Acetone, Chloroform, Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: 5-Benzyloxy-6-methoxy-1-indanone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Benzyloxy-6-methoxy-1-indanone(127399-72-8)
• EPA Substance Registry System: 5-Benzyloxy-6-methoxy-1-indanone(127399-72-8)

Safety Data

• Hazardous Substances Data: 127399-72-8(Hazardous Substances Data)

Usage

Chemical Properties

Tan Solid

Upstream product

• 127399-78-4 5-hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one 
• 100-39-0 benzyl bromide 
• 2107-69-9 5,6-dimethoxy-1-indanone 
• 1135-15-5 dihydroisoferulic acid 
• 100-44-7 benzyl chloride 

Downstream Products

• 760992-27-6 5-(benzyloxy)-2-(4-bromobenzoyl)-6-methoxyindan-1-one 
• 68360-26-9 6-benzyloxy-7-methoxy-3,4-dihydro-2H-isoquinolin-1-one 
• 1064206-58-1 methyl 2-((7-methoxy-1-oxo-6-(sulfamoyloxy)-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoate 
• 1064202-00-1 2-((3-chlorophenyl)sulfonyl)-7-methoxy-6-(sulfamoyloxy)-3,4-dihydroisoquinolin-1(2H)-one 
• 1064201-98-4 7-methoxy-2-((4-methoxyphenyl)sulfonyl)-6-(sulfamoyloxy)-3,4-dihydroisoquinolin-1(2H)-one 
• 1064201-94-0 7-methoxy-2-((3-methoxyphenyl)sulfonyl)-6-(sulfamoyloxy)-3,4-dihydroisoquinolin-1(2H)-one 
• 1064201-93-9 7-methoxy-2-((2-methoxyphenyl)sulfonyl)-6-(sulfamoyloxy)-3,4-dihydroisoquinolin-1(2H)-one 
• 1064206-55-8 methyl 2-((6-hydroxy-7-methoxy-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoate 
• 1064201-91-7 6-hydroxy-7-methoxy-2-((3-chlorophenyl)sulfonyl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1064201-88-2 6-hydroxy-7-methoxy-2-((4-methoxyphenyl)sulfonyl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1064201-86-0 6-hydroxy-7-methoxy-2-((3-methoxyphenyl)sulfonyl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1064201-84-8 6-hydroxy-7-methoxy-2-((2-methoxyphenyl)sulfonyl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1064201-81-5 6-benzyloxy-7-methoxy-2-((3-chlorophenyl)sulfonyl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1064201-79-1 6-benzyloxy-7-methoxy-2-((4-methoxyphenyl)sulfonyl)-3,4-dihydroisoquinolin-1(2H)-one 

Relevant articles and documents

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Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

Monomethyl Ether Derivatives of 7,8-Dihydroxy- and 8,9-Dihydroxy-4-n-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzoquinolines as Possible Products of Metabolism by Catechol-O-methyltransferase

In order to facilitate identification of possible metabolites arising from in vitro action of catechol-O-methyltransferase upon 7,8-dihydroxy- and 8,9-dihydroxy-4-n-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzoquinolines (11, 12), all four possible monomethyl ether derivatives have been synthesized.Incubation of 11 and 12 with the enzyme revealed that the 8,9-dihydroxy positional isomer 12 (which contains the dopamine moiety held in the β conformation) but not the 7,8-dihydroxy isomer 11 (which holds the dopamine moiety in the α conformation) was a substrate for theenzyme.The sole detectable product of 12 was 8-hydroxy-9-methoxy derivative 15 in which the "meta" hydroxy group of the dopamine moiety is etherified.