- Cine-Substitutions at Five-Membered Hetarenes Enabled by Sulfonium Salts
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We report a nucleophilic substitution reaction of five-membered hetarylsulfonium salts that results in a change of the substitution pattern on the arene. The products of these cine-substitutions are hard to access synthetically otherwise. The sulfonium salts that serve as starting materials are generated by a highly site-selective C-H functionalization reaction.
- Alvarez, Eva Maria,Barletta, Joana,Berger, Florian,Bohdan, Kostiantyn,Engl, Pascal S.,Frank, Nils,Kondratiuk, Mykhailo,Ritter, Tobias,Torkowski, Luca
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supporting information
(2020/07/24)
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- Ethyl cyanoacetate: A new cyanating agent for the palladium-catalyzed cyanation of aryl halides
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A new Pd-catalyzed cyanation reaction has been discovered using ethyl cyanoacetate as the cyanating reagent. A variety of electron-rich and electron-deficient aryl halides were efficiently converted into their corresponding nitriles in good to excellent yields.
- Zheng, Shuyan,Yu, Chunhui,Shen, Zhengwu
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supporting information; experimental part
p. 3644 - 3647
(2012/08/28)
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- Synthesis of methyl-, fluoro-, and chloro-substituted 6-hydroxyisoindolin-1-ones
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The synthesis of a series of methyl-, fluoro-, and chloro-substituted 6-hydroxyisoindolin-1-ones is described.
- Powers, James J.,Favor, David A.,Rankin, Trent,Sharma, Rashmi,Pandit, Chetan,Jeganathan, Azhwarsamy,Maiti, Samarendra N.
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supporting information; experimental part
p. 1267 - 1269
(2009/09/05)
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- ISOINDOLE DERIVATIVES
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This invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, a process of making these compounds, pharmaceutical compositions containing one or more of these compounds or their salts, and their use for the treatment of schizophrenia, bipolar disorder, or other central nervous system disorders.
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Page/Page column 26
(2010/11/30)
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- DIPHENYLMETHANE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS
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The instant invention provides compounds of Formula I which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents.
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Page/Page column 47-48
(2008/06/13)
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