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CAS

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127786-29-2

Epinastine hydrobromide is a second-generation H1 receptor antagonist, primarily used as an antihistamine for the treatment of allergic conjunctivitis and other allergic reactions. It functions by blocking the action of histamine, a chemical released during an allergic response, thereby alleviating symptoms such as itching and redness. Epinastine hydrobromide is available in ophthalmic solution form, providing rapid and sustained relief for those with allergic eye conditions and is recognized as a safe and effective treatment option for individuals with allergic conjunctivitis.

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  • 127786-29-2 Structure

  • Basic information

    1. Product Name: Epinastine hydrobromide
    2. Synonyms: (+/-)-3-amino-9,13b-dihydro-1h-dibenz[c,f]imidazo[1,5-a]azepine hydrobromide;epinastine hydrobromide;EPINASTIN HBR;Epinastine HBr;9,13b-Dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine hydrobromide
    3. CAS NO:127786-29-2
    4. Molecular Formula: BrH*C16H15N3
    5. Molecular Weight: 330.22234
    6. EINECS: 1312995-182-4
    7. Product Categories: N/A
    8. Mol File: 127786-29-2.mol

  • Chemical Properties

    1. Melting Point: 284-286°
    2. Boiling Point: 428 °C at 760 mmHg
    3. Flash Point: 212.7 °C
    4. Appearance: /
    5. Density: N/A
    6. Vapor Pressure: 1.56E-07mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: Sealed in dry,Room Temperature
    9. Solubility: N/A
    10. CAS DataBase Reference: Epinastine hydrobromide(CAS DataBase Reference)
    11. NIST Chemistry Reference: Epinastine hydrobromide(127786-29-2)
    12. EPA Substance Registry System: Epinastine hydrobromide(127786-29-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 127786-29-2(Hazardous Substances Data)

127786-29-2 Usage

Uses

Used in Pharmaceutical Industry:
Epinastine hydrobromide is used as an antihistamine for the treatment of allergic conjunctivitis, providing rapid and lasting relief from symptoms such as itching and redness in the eyes. Its mechanism of action involves blocking histamine, a chemical released by the body during an allergic reaction, making it an effective treatment for individuals suffering from allergic eye conditions.
Used in Ophthalmic Solutions:
Epinastine hydrobromide is used as an active ingredient in ophthalmic solutions, specifically formulated to treat allergic eye conditions. The ophthalmic solution form allows for targeted delivery to the affected area, ensuring effective relief from symptoms associated with allergic conjunctivitis and other allergic reactions in the eyes.

Check Digit Verification of cas no

The CAS Registry Mumber 127786-29-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,7,8 and 6 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 127786-29:
(8*1)+(7*2)+(6*7)+(5*7)+(4*8)+(3*6)+(2*2)+(1*9)=162
162 % 10 = 2
So 127786-29-2 is a valid CAS Registry Number.
InChI:InChI=1/C16H15N3.BrH/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16;/h1-8,15H,9-10H2,(H2,17,18);1H

127786-29-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Epinastine hydrobromide

1.2 Other means of identification

Product number -
Other names 3-amino-9,13b-dihydro-1H-dibenzo-[c,f]imidazo[1,5-a]-azepine hydrobromide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:127786-29-2 SDS

127786-29-2Relevant articles and documents

A new process for the preparation of 3-amino-9,13b-dihydro-1H-dibenz [c,f] imidazo[1,5-a]azepine bromic acid salt

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Paragraph 0017; 0060-0063, (2016/12/07)

The present invention relates to a novel method for preparing an enhanced 3-amino-9, 13b-dihydro-1H-dibenz [c,f] imidazo [1,5-a] azepine bromic acid salt. The compound is used as an intermediate in manufacturing the epinastine hydrochloride. The compound is represented by the structural formula (I).COPYRIGHT KIPO 2015

NOVEL CRYSTAL MODIFICATION OF EPINASTINE OR SALTS THEREOF AND PROCESS FOR PREPARATION THEREOF

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Page/Page column 25, (2009/06/27)

The present invention provides novel crystalline forms of 3-amino-9,13b-dihydro-lH- dibenzo[c,f]imidazo[l55-a] azepine or salts thereof and process for preparation thereof.

New tetracyclic guanidine derivatives with H1-antihistaminic properties. Chemistry of epinastine

Walther,Daniel,Bechtel,Brandt

, p. 440 - 446 (2007/10/02)

A series of new tetracyclic guanides were synthesized by various methods. Specific binding of the described compounds to histamine-1 and histamine-2 receptors was determined. The compound 3-amino-9, 13b-dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepine (epinastine, WAL 801) combines high selectivity with high affinity for the H1 receptor and was selected from the compounds studied for further pharmacological and clinical investigations. Experimentally determined physicochemical parameters (pk(a)-value, partition coefficient) and the hydrogen-bonding ability of epinastine are indications that this compound will not easily cross the blood-brain barrier. This explains the absence of CNS side-effects of epinastine in pharmacological and clinical studies.

FUSED DIBENZO IMIDAZOLO COMPOUNDS, COMPOSITIONS AND USE

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, (2008/06/13)

This invention relates to a compound of the formula wherein R1, R2, R3, and R4, which may be the same or different, each represent a hydrogen or halogen atom or an alkyl or alkoxy group of from 1 to 6 carbon atoms; R5 and R6, which may be the same or different, each represent a hydrogen atom, an alkyl group of from 1 to 6 carbon atoms, or an alkenyl group of from 3 to 6 carbon atoms, or R5 and R6 together with the nitrogen atom to which they are attached represent a pyrrolidino, piperidino, or morpholino group; and X represents oxygen, sulfur, or a methylene group, or a non-toxic, pharmacologically acceptable acid addition salt thereof, or a racemate, enantiomer, or mixture of enantiomers thereof. The compounds of Formula I are useful in pharmaceutical compositions for treating bronchial asthma and allergic bronchitis

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