127919-28-2

Basic information

• Product Name: Ethyl 5-(4-chlorophenyl)oxazole-4-carboxylate
• Synonyms: Ethyl 5-(4-chlorophenyl)oxazole-4-carboxylate;5-(4-Chloro-phenyl)-oxazole-4-carboxylic acid ethyl ester
• CAS NO: 127919-28-2
• Molecular Formula: C₁₂H₁₀ClNO₃
• Molecular Weight: 251.67
• Product Categories: blocks;Carboxes;Oxazoles
• Mol File: 127919-28-2.mol

Chemical Properties

• Boiling Point: 390.4 °C at 760 mmHg
• Flash Point: 189.9 °C
• Appearance: /
• Density: 1.276
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Ethyl 5-(4-chlorophenyl)oxazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 5-(4-chlorophenyl)oxazole-4-carboxylate(127919-28-2)
• EPA Substance Registry System: Ethyl 5-(4-chlorophenyl)oxazole-4-carboxylate(127919-28-2)

Safety Data

• Hazardous Substances Data: 127919-28-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
Ethyl 5-(4-chlorophenyl)oxazole-4-carboxylate is utilized as a building block for the synthesis of biologically active molecules, given its inherent potential for antimicrobial, antifungal, and anti-inflammatory activities. Its structural and reactive properties make it a valuable component in the creation of new pharmaceutical agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, Ethyl 5-(4-chlorophenyl)oxazole-4-carboxylate is employed as a versatile intermediate. Its reactivity and structural features allow for the development of various pharmaceuticals, contributing to the advancement of treatments for a multitude of diseases and conditions.
Used in Agrochemicals:
Ethyl 5-(4-chlorophenyl)oxazole-4-carboxylate also finds application in the agrochemical industry, where its biological activities can be harnessed for the development of products that address challenges in agriculture, such as crop protection and pest management.
Used in Chemical Synthesis:
As a chemical intermediate, Ethyl 5-(4-chlorophenyl)oxazole-4-carboxylate is used in the synthesis of a variety of compounds, expanding its utility beyond the realms of medicine and agriculture into broader chemical applications.

Upstream product

• 2999-46-4 Ethyl isocyanoacetate 
• 74-11-3 para-chlorobenzoic acid 
• 122-01-0 4-chloro-benzoyl chloride 
• 7099-88-9 4-chlorophenylglyoxylic acid 
• 99-91-2 para-chloroacetophenone 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 127919-16-8 t-butyl [2-[5-(4-chlorophenyl)-4-oxazolecarboxamido]ethyl]carbamate 
• 197460-83-6 5-(4-chlorophenyl)oxazole-4-carboxaldehyde 

Relevant articles and documents

Reaction method for selectively synthesizing oxazole-4-carboxylic ester

The invention provides a reaction method for selectively synthesizing oxazole-4-carboxylic ester, which comprises the following steps of reacting by taking aromatic aldehyde serving as a raw material,cuprous salt serving as a catalyst and organic amine serving as an additive in a solvent in a nitrogen or argon atmosphere to obtain oxazole-4-carboxylic ester serving as a main product. The synthesis method provided by the invention has the characteristics of atom economy and high selectivity, uses substituted benzaldehyde and aromatic heterocyclic formaldehyde as substrates, and has the advantages of low price, easiness in obtaining, no generation of waste acid and waste gas and the like; the metal copper salt is used for catalyzing, so that the method has the advantages of low cost, easiness in obtaining, wide substrate applicability, simple post-treatment, good reaction selectivity and the like.

Synthesis of oxazoles by silver catalysed oxidative decarboxylation-cyclization of α-oxocarboxylates and isocyanides

A silver catalysed synthesis of oxazoles by the oxidative decarboxylation-cyclization of α-oxocarboxylates and isocyanides was developed. This method provided a novel strategy to construct oxazole rings compared to traditional methods. Mechanistic investigations such as operando IR, EPR and radical inhibition experiments were carefully done and confirmed the acyl cation and Ag(ii) as the intermediates in this transformation, and the involvement of a radical decarboxylative process.

5-MEMBERED HETEROARYLS AND THEIR USE AS ANTIVIRAL AGENTS

Compounds of formula (I): or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

COMPOUNDS FOR TREATING AND PREVENTING COGNITIVE DISEASES AND DEPRESSION AND METHODS OF MAKING SAME

Ethylenediamine monoamides of the formula R--CO--NH--CH2 --CH2 --NH2. wherein R is one of groups in which R1 is phenyl monohalophenyl, monolower-alkylphenyl, monolower-alkoxypheynl, monotrifluoromethylphenyl, monocyanophenyl or monoaryl-lower-alkoxyphenyl, dihalophenyl, furyl, thienyl or monohalothienyl, R2 is hydrogen, halogen or amino, R3, R5 and R7 each are phenyl, monohalophenyl, dihalophenyl, thienyl, furyl or monohalofuryl, R4 and R6 each are hydrogen or amino and R8 is hydrogen or lower-alkyl, as well as their pharmaceutically usable acid addition salts are disclosed. The compounds have monoamine oxidase inhibiting properties with low toxicity and are useful for the treatment of depressive states and cognitive disorders