127919-32-8

Basic information

• Product Name: ETHYL 5-(4'-BROMOPHENYL)-1,3-OXAZOLE-4-CARBOXYLATE
• Synonyms: ETHYL 5-(4'-BROMOPHENYL)-1,3-OXAZOLE-4-CARBOXYLATE;5-(4-BROMO-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;Ethyl 5-(4-broMophenyl)oxazole-4-carboxylate;Ethyl5-(4'-broMophenyl)-1,3-oxazole;4-Oxazolecarboxylic acid, 5-(4-bromophenyl)-, ethyl ester
• CAS NO: 127919-32-8
• Molecular Formula: C₁₂H₁₀BrNO₃
• Molecular Weight: 296.12
• Mol File: 127919-32-8.mol

Chemical Properties

• Boiling Point: 409.6 °C at 760 mmHg
• Flash Point: 201.5 °C
• Appearance: /
• Density: 1.47 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -1.53±0.10(Predicted)
• CAS DataBase Reference: ETHYL 5-(4'-BROMOPHENYL)-1,3-OXAZOLE-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 5-(4'-BROMOPHENYL)-1,3-OXAZOLE-4-CARBOXYLATE(127919-32-8)
• EPA Substance Registry System: ETHYL 5-(4'-BROMOPHENYL)-1,3-OXAZOLE-4-CARBOXYLATE(127919-32-8)

Safety Data

• Hazardous Substances Data: 127919-32-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
ETHYL 5-(4'-BROMOPHENYL)-1,3-OXAZOLE-4-CARBOXYLATE is used as a key intermediate in the synthesis of various pharmaceuticals for its unique structural features and reactivity. Its presence in the molecular structure can contribute to the development of new drugs with improved therapeutic properties.
Used in Agrochemicals:
In the agrochemical industry, ETHYL 5-(4'-BROMOPHENYL)-1,3-OXAZOLE-4-CARBOXYLATE is used as a building block for the creation of novel agrochemicals, potentially enhancing crop protection and yield through its incorporation into active ingredients.
Used in Organic Synthesis:
ETHYL 5-(4'-BROMOPHENYL)-1,3-OXAZOLE-4-CARBOXYLATE serves as a versatile reagent in organic synthesis, enabling the formation of a variety of complex organic molecules. Its carboxylate ester functional group and bromophenyl moiety facilitate multiple reaction pathways, expanding the scope of synthetic chemistry.
Used in Medicinal Chemistry Research:
As a component in medicinal chemistry, ETHYL 5-(4'-BROMOPHENYL)-1,3-OXAZOLE-4-CARBOXYLATE is utilized in the study of biologically active molecules. Its unique structural elements can be explored for their potential to interact with biological targets, leading to the discovery of new therapeutic agents.

Upstream product

• 2999-46-4 Ethyl isocyanoacetate 
• 586-75-4 4-chlorobenzoyl chloride 
• 586-76-5 4-Bromobenzoic acid 
• 7099-87-8 4-bromophenylglyoxylic acid 
• 99-90-1 para-bromoacetophenone 

Downstream Products

• 127919-20-4 t-butyl [2-[5-(4-bromophenyl)-4-oxazolecarboxamido]ethyl]carbamate 
• 1082444-81-2 tert-butyl 4-(4-(4-(ethoxycarbonyl)oxazol-5-yl)phenyl)piperazine-1-carboxylate 
• 1249008-71-6 5-(4-bromophenyl)oxazole-4-carboxylic acid 
• 1380587-35-8 [5-(4-bromophenyl)oxazol-4-yl]carbamic acid (R)-1-phenylethyl ester 
• 1423694-17-0 C₂₉H₂₆N₂O₅ 
• 1380587-34-7 1-{4'-[4-((R)-1-phenylethoxycarbonylamino)oxazol-5-yl]biphenyl-4-yl}cyclopropanecarboxylic acid 
• 1423694-19-2 C₂₈H₂₃N₂O₅^(1-)*Na⁽¹⁺⁾ 

Relevant articles and documents

Synthesis of oxazoles by silver catalysed oxidative decarboxylation-cyclization of α-oxocarboxylates and isocyanides

A silver catalysed synthesis of oxazoles by the oxidative decarboxylation-cyclization of α-oxocarboxylates and isocyanides was developed. This method provided a novel strategy to construct oxazole rings compared to traditional methods. Mechanistic investigations such as operando IR, EPR and radical inhibition experiments were carefully done and confirmed the acyl cation and Ag(ii) as the intermediates in this transformation, and the involvement of a radical decarboxylative process.

LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS

Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provided.

OXAZOLE TYROSINE KINASE INHIBITORS

The invention provides a compound which is an amide of the formula (1), or a salt, solvate, N-oxide or tautomer thereof; wherein: a is 0 or 1; b is 0 or 1 : provided that the sum of a and b is 0 or 1; T is O or NH Ar1 is a monocyclic or bicyclic 5- to 10-membered aryl or heteroaryl group containing up to 4 heteroatoms selected from O, N and S, and being optionally substituted by one or more substituents R1; Ar2 Js a monocyclic or bicyclic 5- to 10-membered aryl or heteroaryl group containing up to 4 heteroatoms selected from O, N and S and being optionally substituted by one or more substituents R2; and R1 and R2are as defined in the claims. The compounds are inhibitors of kinases and in particular FLT3, FLT4 and Aurora kinases.

Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles

A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesis platform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The reactor is configu

COMPOUNDS FOR TREATING AND PREVENTING COGNITIVE DISEASES AND DEPRESSION AND METHODS OF MAKING SAME

Ethylenediamine monoamides of the formula R--CO--NH--CH2 --CH2 --NH2. wherein R is one of groups in which R1 is phenyl monohalophenyl, monolower-alkylphenyl, monolower-alkoxypheynl, monotrifluoromethylphenyl, monocyanophenyl or monoaryl-lower-alkoxyphenyl, dihalophenyl, furyl, thienyl or monohalothienyl, R2 is hydrogen, halogen or amino, R3, R5 and R7 each are phenyl, monohalophenyl, dihalophenyl, thienyl, furyl or monohalofuryl, R4 and R6 each are hydrogen or amino and R8 is hydrogen or lower-alkyl, as well as their pharmaceutically usable acid addition salts are disclosed. The compounds have monoamine oxidase inhibiting properties with low toxicity and are useful for the treatment of depressive states and cognitive disorders