- Concise syntheses of the amaryllidaceae alkaloids ungerimine and hippadine via the suzuki aryl-aryl cross coupling reaction
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Short syntheses of the betaine alkaloid ungerimine (1) and the lactam alkaloid hippadine (4) based on aryl boronic acid - aryl halide cross coupling methodology are described.
- Siddiqui,Snieckus
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Read Online
- Nickel-catalyzed C-O activation of phenol derivatives with potassium heteroaryltrifluoroborates
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A general method based on nickel-catalyzed C-O activation of various phenol derivatives with potassium (hetero)aryltrifluoroborates has been developed. A large number of heterobiaryls can be easily obtained with yields up to 99% using methanesulfonate cross-coupling partners.
- Molander, Gary A.,Beaumard, Floriane
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supporting information; experimental part
p. 4022 - 4025
(2010/11/05)
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- A mild and efficient palladium-catalyzed cyanation of aryl mesylates in water or tBuOH/water
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Cool and compatible: Aryl mesylates and tosylates underwent palladium-catalyzed cyanation under mild, aqueous conditions at 65-80°C (see scheme). In many cases, water could be used as the reaction medium without a cosolvent, and a variety of substituents R, such as keto, aldehyde, ester, free amine, and nitrile groups, remained intact during the transformation. Cy=cyclohexyl, Ms=methanesulfonyl, Ts=p-toluenesulfonyl.
- Yeung, Pui Yee,So, Chau Ming,Lau, Chak Po,Kwong, Fuk Yee
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supporting information; experimental part
p. 8918 - 8922
(2011/02/24)
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- NOVEL COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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The present invention relates to novel compounds of formula (I) and their pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds.
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Page/Page column 50-51
(2010/02/11)
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