128944-41-2

Basic information

• Product Name: BUTTPARK 139\40-45
• Synonyms: BUTTPARK 139\40-45;4-(4-BENZYLOXYBENZYLIDENE)-2-PHENYL-2-OXAZOLIN-5-ONE;4-(4-BENZYLOXY-BENZYLIDENE)-2-PHENYL-4H-OXAZOL-5-ONE
• CAS NO: 128944-41-2
• Molecular Formula: C₂₃H₁₇NO₃
• Molecular Weight: 355.39
• Mol File: 128944-41-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BUTTPARK 139\40-45(CAS DataBase Reference)
• NIST Chemistry Reference: BUTTPARK 139\40-45(128944-41-2)
• EPA Substance Registry System: BUTTPARK 139\40-45(128944-41-2)

Safety Data

• Hazardous Substances Data: 128944-41-2(Hazardous Substances Data)

Upstream product

• 495-69-2 Hippuric Acid 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 836-43-1 4-benzyloxybenzyl alcohol 
• 98-88-4 benzoyl chloride 

Downstream Products

• 128944-42-3 7-(Benzyloxy)-1-<4-(benzyloxy)benzyl>-1,2,3,4-tetrahydro-6-hydroxyisoquinoline-1-carboxylic Acid 
• 128437-99-0 (4-Benzyloxy)pyruvic Acid 

Relevant articles and documents

Antileshmanial activities of synthetic substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones

Substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones 1-27 were evaluated for their activity against Leishmania major. Compounds 1-27 demonstrated in vitro antileishmanial activities with IC50 values between 28.9 - 69.05 μM, as compared to standard drug pentamidine (IC50 = 5.09 ± 0.04 μM). Compounds 12 (IC50 = 28.90 ± 1.10 μM), 24 (IC50 = 31.4 ± 2.15 μM), 13 (IC50 = 35.0 ± 3.18 μM), 16 (IC50 = 35.0 ± 3.13 μM), and 25 (IC50 = 35.0 ± 3.18μM) displayed signifiant antileishmanial activities. Whereas, compounds 8-10, 15, 19, and 26 with IC50 values of 62.2 ± 3.36, 57.8 ± 2.30, 57.72 ± 5.02, 56.18 ± 4.40, 57.85 ± 2.25, 69.05 ± 6.20, 54.8 ± 1.50, and 57.8 ± 2.30 μM showed a moderate antileishmanial activities.

Organic-inorganic hybrid polyoxometalates: Efficient, heterogeneous and reusable catalysts for solvent-free synthesis of azlactones

Two organic-inorganic hybrid polyoxometalates, consist of 1-butyl-3-methylimidazolium salts of (W10O32)4- and (PW12O40)3- polyanions were prepared and characterized by thermal analysis, X-ray diffraction, FT-IR, diffuse reflectance UV-Vis spectroscopic methods and nitrogen absorption-desorption determination (BET). These heterogeneous catalysts were used for synthesis of azlactones by the reaction of aldehydes with hippuric acid and acetic anhydride under solvent-free conditions. These catalysts were reused several times without loss of their activities.

2W10O32. 2H2O: A novel and powerful catalyst for the synthesis of 4-arylidene-2-phenyl-5(4)-oxazolones under ultrasonic condition

Di[1,6-bis(3-methylimidazolium-1-yl)hexane] decatungstate dihydrate ([C6(MIm)2]2W10O32. 2H2O) as a new family of polyoxometalate-based dicationic ionic liquids (POM-DIL) is synthesized and employed as a novel and powerful heterogeneous catalyst in the synthesis of 4-arylidene-2-phenyl-5(4)-oxazolones (azlactones) under ultrasound-assisted solvent-free condition. On the basis of the results, the products were obtained in excellent yields under mild condition. Utilization of easy work-up and purification make it very interesting from an economic perspective. Moreover, a recycling study confirmed that the catalyst can be reused multiple times without significant loss of its activity.

Novel and chemoselective one-pot synthesis of 4-arylidene-2-phenyl-5(4H)- oxazolones starting from benzyl alcohols promoted by [(C14H 24N4)2W10O32]-[bmim] NO3

A new and practical promoter system for one-pot, efficient, chemoselective synthesis of 4-arylidene-2-phenyl-5(4H)-oxazolones using [(C14H 24N4)2W10O32]-[bmim] NO3 under solvent-free conditions is described. The present work opens up a new and ecofriendly synthetic route to Erlenmeyer-Ploechl adducts from primary benzyl alcohols in a one-pot operation. Graphical abstract: [Figure not available: see fulltext.]

46. Mammalian Alkaloids: O-Methylation of (+/-)-Norcoclaurine-1-carboxylic Acid and Related Isoquinolines Including (S)- and (R)-Norcoclaurine with 14C-Labeled S-Adenosyl-L-Methionine in Presence of Mammalian Catechol O-Methyltransferase

(+/-)-Norcoclaurine-1-carboxylic acid (5) and the derived dihydroisoquinolinone 6 (present as quinonemethide 6a at pH 7) afforded, on methylation with 14C-labeled S-adenosyl-L-methionine in the presence of mammalian catechol O-methyltransferase, exclusively the 7-O-methylated congeners 7 and 9, respectively.High stereoselectivity of the O-methylation was observed with (-)-(S)- and (+)-(R)-norcoclaurine (2a and 2b, resp.), affording 80percent of 6-O-methylated isoquinoline 12 and 20percent of the 7-O-methylated isomer 11 from 2a, and the reversed proportion of 12 and 11 from 2b.Synthesis of the reference amino acid 8 was achieved by Pictet-Spengler condensation of O-benzyl-protected dopamine 17 with benzyl-protected keto acid 20 (-> 21) followed by methylation with diazomethane (-> 22 + 23) and removal of the protecting groups by acid hydrolysis.It is considered unlikely that amino acids such as 5 constitute important precursors in the biosynthesis of isoquinolines related to reticuline.