128437-99-0

Basic information

• Product Name: (4-Benzyloxy)pyruvic Acid
• CAS NO: 128437-99-0
• Molecular Weight: 270.285
• Mol File: 128437-99-0.mol

Chemical Properties

• CAS DataBase Reference: (4-Benzyloxy)pyruvic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Benzyloxy)pyruvic Acid(128437-99-0)
• EPA Substance Registry System: (4-Benzyloxy)pyruvic Acid(128437-99-0)

Safety Data

• Hazardous Substances Data: 128437-99-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(4-Benzyloxy)pyruvic Acid is used as an intermediate in the synthesis of pharmaceuticals for its potential biological activity. It plays a crucial role in the development of new drugs and organic products, contributing to the advancement of medical treatments.
Used in Flavor and Fragrance Production:
(4-Benzyloxy)pyruvic Acid is used as a component in the production of flavors and fragrances, adding unique scents and tastes to various consumer products. Its presence in these products enhances the sensory experience for users.
Further Research:
(4-Benzyloxy)pyruvic Acid is a compound of interest for its potential applications in the pharmaceutical industry. However, further research is needed to fully understand its properties and potential uses, ensuring that it can be effectively and safely utilized in various applications.

Upstream product

• 112520-26-0 (4-benzyloxy-phenyl)-pyruvic acid methyl ester 
• 128944-41-2 4-<4-(Benzyloxy)benzylidene>-2-phenyloxazol-5(4H)-one 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 156-39-8 4-hydroxyphenylpiruvic acid 
• 154722-74-4 methyl 2-oxo-3-(4-hydroxyphenyl)propionate 

Downstream Products

• 128944-42-3 7-(Benzyloxy)-1-<4-(benzyloxy)benzyl>-1,2,3,4-tetrahydro-6-hydroxyisoquinoline-1-carboxylic Acid 

Relevant articles and documents

SELECTED CGRP ANTAGONISTS, METHODS FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS

The invention relates to CGRP antagonists of general formula (I), in which A, X, D, E, G, M, Q and R1 to R3 are defined as in Claim 1, to their tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures and their salts as well as the hydrates of the salts, particularly their physiologically compatible salts having inorganic or organic acids, to medicaments containing these compounds, to their use, and to methods for the production thereof.

46. Mammalian Alkaloids: O-Methylation of (+/-)-Norcoclaurine-1-carboxylic Acid and Related Isoquinolines Including (S)- and (R)-Norcoclaurine with 14C-Labeled S-Adenosyl-L-Methionine in Presence of Mammalian Catechol O-Methyltransferase

(+/-)-Norcoclaurine-1-carboxylic acid (5) and the derived dihydroisoquinolinone 6 (present as quinonemethide 6a at pH 7) afforded, on methylation with 14C-labeled S-adenosyl-L-methionine in the presence of mammalian catechol O-methyltransferase, exclusively the 7-O-methylated congeners 7 and 9, respectively.High stereoselectivity of the O-methylation was observed with (-)-(S)- and (+)-(R)-norcoclaurine (2a and 2b, resp.), affording 80percent of 6-O-methylated isoquinoline 12 and 20percent of the 7-O-methylated isomer 11 from 2a, and the reversed proportion of 12 and 11 from 2b.Synthesis of the reference amino acid 8 was achieved by Pictet-Spengler condensation of O-benzyl-protected dopamine 17 with benzyl-protected keto acid 20 (-> 21) followed by methylation with diazomethane (-> 22 + 23) and removal of the protecting groups by acid hydrolysis.It is considered unlikely that amino acids such as 5 constitute important precursors in the biosynthesis of isoquinolines related to reticuline.