129075-56-5

Basic information

• Product Name: 1(2H)-Isoquinolinone, 3,4-dihydro-5-methyl-
• Synonyms: 1(2H)-Isoquinolinone, 3,4-dihydro-5-methyl-;3,4-dihydro-5-methyl-1(2H)-isoquinolinone;3,4-Dihydro-5-methoxyisoquinolin-1(2H)one;Pd 128763;5-Methyl-1,2,3,4-tetrahydroisoquinolin-1-one
• CAS NO: 129075-56-5
• Molecular Formula: C10H11NO
• Molecular Weight: 161.08
• Mol File: 129075-56-5.mol

Chemical Properties

• Boiling Point: 413.769 °C at 760 mmHg
• Flash Point: 243.511 °C
• Appearance: /
• Density: 1.111
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 15.12±0.20(Predicted)
• CAS DataBase Reference: 1(2H)-Isoquinolinone, 3,4-dihydro-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1(2H)-Isoquinolinone, 3,4-dihydro-5-methyl-(129075-56-5)
• EPA Substance Registry System: 1(2H)-Isoquinolinone, 3,4-dihydro-5-methyl-(129075-56-5)

Safety Data

• Hazardous Substances Data: 129075-56-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1(2H)-Isoquinolinone, 3,4-dihydro-5-methylis used as a potential antipsychotic agent for its ability to interact with GABA receptors in the brain, which may help in managing symptoms associated with psychotic disorders.
1(2H)-Isoquinolinone, 3,4-dihydro-5-methylis also used as a potential anxiolytic agent for its potential to modulate GABAergic neurotransmission, which could provide relief from anxiety symptoms.
Additionally, the compound's structure and properties make it a subject of interest for research in drug development, where it may be further explored for other therapeutic applications based on its interaction with GABA receptors.

InChI:InChI=1/C10H11NO/c1-7-3-2-4-9-8(7)5-6-11-10(9)12/h2-4H,5-6H2,1H3,(H,11,12)

Upstream product

• 24188-72-5 5-methylisoquinolin-1(2Η)-one 
• 24644-78-8 4-methylindanone 
• 55755-16-3 2-methylphenethylamine 

Relevant articles and documents

Synthesis of 3,4-dihydro-1(2H)-isoquinolinones

Approaches toward the preparative-scale synthesis of target 3,4-dihydro-1(2H)-isoquinolinones 1-3 are presented. Compounds 1 and 2 were prepared via a Schmidt rearrangement on easily obtained indanone precursors, but in low overall yield. A better method

Rational Design of Cell-Active Inhibitors of PARP10

Poly-ADP-ribose polymerases (PARPs 1-16) have emerged as major regulators of diverse cellular processes. PARPs can be subclassified based on their ability to catalyze poly-ADP-ribosylation (PARylation) or mono-ADP-ribosylation (MARylation). While much is

Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process

The invention is selected, novel, and known analogs of isoquinolinones of the formula and pharmaceutically acceptable salts thereof; novel pharmaceutical compositions; and a method for enhancing the lethal effects for tumor cells to treatment having DNA damaging activity such as ionizing radiation or with chemotherapeutic agents.