129077-96-9

Basic information

• Product Name: L-TYROSINE-BETA-13C
• Synonyms: L-TYROSINE-BETA-13C;L-TYROSINE (3-13C);L-TYROSINE-BETA-13C, 99 ATOM % 13C;l-4-hydroxyphenylalanine-3-13c;L-Tyrosine-β-13C
• CAS NO: 129077-96-9
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 182.2
• Product Categories: Amino Acids 13C, 2H, 15N
• Mol File: 129077-96-9.mol

Chemical Properties

• Melting Point: >300 °C (dec.)(lit.)
• Appearance: /
• CAS DataBase Reference: L-TYROSINE-BETA-13C(CAS DataBase Reference)
• NIST Chemistry Reference: L-TYROSINE-BETA-13C(129077-96-9)
• EPA Substance Registry System: L-TYROSINE-BETA-13C(129077-96-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 129077-96-9(Hazardous Substances Data)

Usage

Uses

Used in Biochemical and Medical Research:
L-TYROSINE-BETA-13C is used as a tracer for metabolic studies, allowing researchers to track and measure the metabolism of tyrosine in biological systems. This is crucial for understanding processes such as protein synthesis and neurotransmitter production.
Used in Nuclear Magnetic Resonance (NMR) Spectroscopy:
L-TYROSINE-BETA-13C is used in the production of labeled compounds for NMR spectroscopy, a technique that provides detailed information about the structure and dynamics of molecules. The carbon-13 labeling enhances the sensitivity and resolution of NMR spectra, facilitating the study of complex biological systems.
Used in Mass Spectrometry:
L-TYROSINE-BETA-13C is also used in the production of labeled compounds for mass spectrometry, a technique that measures the mass-to-charge ratio of ions. The carbon-13 labeling improves the accuracy and precision of mass measurements, enabling the identification and quantification of specific metabolites and proteins in biological samples.

Upstream product

• 131157-42-1 13C^β-alanine 
• 108-95-2 phenol 
• 220077-36-1 Methylparaben-¹³C 
• 220077-43-0 4-(methoxymethyloxy)phenyl[13C]methanol 
• 220077-26-9 1-[¹³C]-bromomethyl-4-(methoxymethyloxy)benzene 
• 220077-35-0 methyl 4-(methoxymethyloxy)(carbonyl-13C)benzoate 
• 220077-38-3 (3R,5S)-2,3,5,6-tetrahydro-3-[4-(methoxymethyloxy)phenyl[13C]methyl]-5-phenyl-N-(tert-butyloxycarbonyl)-4H-1,4-oxazin-2-one 

Relevant articles and documents

An asymmetric synthesis of L-[3-13C]phenylalanine and L-[3- 13C]tyrosine from [13C]carbon monoxide

L-[3-13C]Phenylalanine and L-[3-13C]tyrosine were synthesized. [α- 13C]Benzyl bromides were prepared from [13C]carbon monoxide via the palladium-catalyzed carboalkoxylation of aryl halides. The asymmetric carbon corresponding to the 2-position in phenylalanine was introduced by the diastereoselective alkylation of Dellaria's oxazinone with [α-13C]benzyl bromides. Finally, ethanolysis, deprotection, hydrogenolysis and acid hydrolysis of the resulting alkylated oxazinones gave L-[3- 13C]phenylalanine and L-[3-13C]tyrosine in high optical purity.

Multi-enzymatic Synthesis of β-11C-Labelled L-Tyrosine and L-DOPA

The synthesis of L-tyrosine (3) and L-DOPA (4) from carbon dioxide via DL-alanine (1) using a combination of organic synthetic methods and a multi-enzymatic procedure are presented.The 11C-labelled alanine was prepared by a methy