PROCESS FOR THE PREPARATION OF AN ENANTIOMERICALLY PURE TRISUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVE
The present invention relates to a process for the preparation of the compound of formula 7, which process comprises: the asymmetric transfer hydrogenation of the compound of formula 4 * HX: wherein HX is as decribed in the description; in the presence of
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Page/Page column 16-17
(2011/02/24)
METHOD FOR THE PREPARATION OF (LS)-6,7-DIMETHOXY-L-[2-(4-TRIFLUOROMETHYLPHENYL)ETHYL]- 1,2,3,4-TETRAHYDROISOQUINOLINE
The solution relates to the substance (15)-6,7-dimethoxy-l-[2-(4- trifluoromethylphenyl)ethyl]-l,2,3,4-tetrahydroisoquinoline of formula I, containing the desired S-enantiomer in an enantiomeric excess higher than or equal to 98.0%. Another solution is a
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Page/Page column 13
(2011/05/06)
TETRAHYDROISOQUINOLYL ACETAMIDE DERIVATIVES FOR USE AS OREXIN RECEPTOR ANTAGONISTS
The invention relates to novel acetamide derivatives of formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compound
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Page 37-38
(2008/06/13)
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