- An efficient synthesis of isomeric 1-(1-Alkyl-1H-pyrazolyl) ethanones
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A simple and versatile general method for the preparation of N-substituted 3-, 4-, or 5-acetylpyrazoles from corresponding acids via hydrolysis and decarboxylation of substituted diethyl [(1-alkyl-1H-pyrazolyl)carbonyl]malonates was developed. Title compounds were prepared in three steps without isolation of intermediates in 48-82% overall yield.
- Taydakov, Ilya,Krasnoselskiy, Sergey
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p. 1422 - 1424
(2013/02/23)
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- PARAMYXOVIRUS FAMILY INHIBITORS AND METHODS OF USE THEREOF
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Embodiments of the present disclosure include methods for identifying a compound or compounds useful as therapeutic agents in the treatment of paramyxovirus infections, compounds for the treatment of measles, and high throughput screening methods for iden
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Page/Page column 4; 11
(2011/07/08)
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- HARMFUL ORGANISM CONTROL COMPOSITION
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This invention provides a harmful organism control composition having an excellent harmful organism control effect and comprising as an effective ingredient the following 4-(2-butynyloxy)-5-fluoro-6-(3,5-dimethylpiperidino)-pyrimidine (X): and a hydrazide compound represented by formula (I): wherein A1 and A2 represent, for example, an oxygen atom; R1, R2, and R3 represent, for example, a hydrogen atom, a C1-6 alkyl group optionally substituted by a halogen atom; and Q represents, for example, a methoxycarbonyl group.
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Page/Page column 27
(2010/05/13)
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- HARMFUL ORGANISM CONTROL COMPOSITION
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This invention provides a harmful organism control composition comprising as an effective ingredient the following 4-(2-chlorobenzyl)-6-(2-butynyloxy)pyrimidine (X): and a hydrazide compound represented by formula (I): wherein A1 and A2 represent, for example, an oxygen atom; R1, R2, and R3 represent, for example, a hydrogen atom, a C1-6 alkyl group optionally substituted by a halogen atom; and Q represents, for example, a methoxycarbonyl group.
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Page/Page column 25
(2010/06/16)
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- Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex activity: Synthesis and in vitro evaluation
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High-throughput screening has identified 1-methyl-3-(trifluoromethyl)-N-[4-(pyrrolidinylsulfonyl)phenyl]-1H-pyrazole-5-carboxamide 16677 as a novel and potent (IC50 = 35-145 nM) inhibitor against multiple primary isolates of diverse measles vir
- Sun, Aiming,Chandrakumar, Nizal,Yoon, Jeong-Joong,Plemper, Richard K.,Snyder, James P.
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p. 5199 - 5203
(2008/02/12)
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- Nonnucleoside inhibitor of measles virus RNA-dependent RNA polymerase complex activity
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Paramyxoviruses comprise several major human pathogens. Although a live-attenuated vaccine protects against measles virus (MV), a member of the paramyxovirus family, the virus remains a principal cause of worldwide mortality and accounts for approximately
- White, Laura K.,Yoon, Jeong-Joong,Lee, Jin K.,Sun, Aiming,Du, Yuhong,Fu, Haian,Snyder, James P.,Plemper, Richard K.
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p. 2293 - 2303
(2008/09/16)
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- HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME
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A hydrazide compound represented by the formula (1): has excellent pesticidal activity.
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Page/Page column 296-297
(2008/06/13)
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- Insecticidal anthranilic diamides: A new class of potent ryanodine receptor activators
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A novel class of anthranilic diamides has been discovered with exceptional insecticidal activity on a range of Lepidoptera. These compounds have been found to exhibit their action by release of intracellular Ca2+ stores mediated by the ryanodine receptor. The discovery, synthesis, structure-activity, and biological results are presented.
- Lahm, George P.,Selby, Thomas P.,Freudenberger, John H.,Stevenson, Thomas M.,Myers, Brian J.,Seburyamo, Gilles,Smith, Ben K.,Flexner, Lindsey,Clark, Christopher E.,Cordova, Daniel
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p. 4898 - 4906
(2007/10/03)
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