129789-59-9Relevant articles and documents
SYNERGISTIC INIHIBITION OF TUMOR CELL PROLIFERATION INDUCED BY COMBINED TREATMENT OF METFORMIN COMPOUNDS AND IRON CHELATORS
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Paragraph 00106-00107, (2018/07/29)
The present invention is directed to combination therapy comprising metformin or mito-metformin compounds with at least one iron chelating agent for the treatment of cancer and pharmaceutical compositions thereof.
MODIFIED MITO-METFORMIN COMPOUNDS AND METHODS OF SYNTHESIS AND USE THEREOF
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Paragraph 0088; 0089, (2016/02/29)
The present invention provides mito-metformin compounds, pharmaceutical compositions thereof, and methods of using the mito-metformin compounds in the treatment of cancer.
Phosphonium lipocations as antiparasitic agents
Long, Timothy E.,Lu, Xiao,Galizzi, Melina,Docampo, Roberto,Gut, Jiri,Rosenthal, Philip J.
scheme or table, p. 2976 - 2979 (2012/06/04)
Phosphonium lipocations were synthesized and evaluated for inhibition of the development of Plasmodium falciparum and Trypanosoma cruzi, etiological agents of malaria and Chagas disease, respectively. Optimal phthalimides and 1,4-naphthoquinone-based lipocations were active in vitro at mid-high nM concentrations against P. falciparum and low μM concentrations against T. cruzi.
ENZYME INHIBITORS AND THE USE THEREOF
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Page/Page column 30; 31, (2010/04/03)
The present invention provides compounds and methods for the treatment of diseases or disorders such as heart failure, hyperlipidemia, hypercholesterolemia, gonadotropin deficiency, diabetes mellitus, metabolic syndrome, hyperglycemia, insulin resistance,
Synthesis of bridged dinucleosides
Agathocleous, Demetrios C.,Bulman Page, Philip C.,Cosstick, Richard,Galpin, Ian J.,McLennan, Alexander G.,Prescott, Mark
, p. 2047 - 2058 (2007/10/02)
A series of di-(adenosin-N6-yl) alkanes (1b) - (11) has been prepared by reaction of the appropriate diaminoalkanes with 6-chloro-9-β-D-(2,3,5-tri-O-acetyl)-ribofuranosyl-purine (2) followed by ammonolysis. Alternatively, an analogous reaction with 6-chloro-9-β-D-(2,3-O-isopropylidene)-ribofuranosylpurine (3) produced an intermediate which could be phosphorylated at the 5′-position prior to hydrolytic removal of the isopropylidene group. 4-(1,2,4-Triazolo)-1-(β-D-2,3,5-tri-O-acetyl ribofuranosyl)-2(1H)-pyrimidone (7) was an effective intermediate for the preparation of di-(cytidin-N4-yl) alkanes (8a), (8b), and (8c) from the appropriate diaminoalkanes. The longer chain di-(adenosin-N6-yl) alkanes are very effective inhibitors of adenosine kinase. In addition an approach to the di-(adenosin-N6-yl) alkanes is described which should allow tritium labelling of the alkyl chain.