129821-08-5Relevant articles and documents
Inhibition of Cryptosporidium parvum in vitro by 9-(alkylthio)acridine derivatives
Khalifa, Latifa,Rosales, Maria-Jose,Mascaro, Carmen,Karolak-Wojciechowska, Janina,Bsiri, Nadia,Brouant, Pierre,Barbe, Jacques
, p. 163 - 166 (2007/10/03)
The synthesis of several acridinic thioethers is described. Compounds prepared were tested in vitro as potential drugs against the opportunistic infection known as cryptosporidiosis. With a view to predict activity, the quantitative structure-activity relationships were investigated. Correlations between experimental data and either log P or pKa are discussed.
Structure-trypanodical activity relationships
Bsiri,Johnson,Kayirere,Galy,Galy,Barbe,Osuna,Mesa-Valle,Castilla Calvente,Rodriguez-Cabezas
, p. 27 - 33 (2007/10/03)
A set of 9-thioalkylacridinones, has been prepared and investigated' in vitro' against T. cruzi. Structure-antiparasitic activity relationships are detailed with a view to identify the major structural parameters for the activity under consideration.