50433-64-2

Usage

InChI:InChI=1/C13H10N2O/c14-8-5-6-10-12(7-8)15-11-4-2-1-3-9(11)13(10)16/h1-7H,14H2,(H,15,16)

Upstream product

• 64-17-5 ethanol 
• 96463-94-4 3-iodo-6-nitro-10H-acridin-9-one 
• 49551-01-1 2-anilino-4-nitrobenzoic acid 
• 1744-91-8 9-chloro-3-nitroacridine 
• 62-53-3 aniline 
• 118-91-2 ortho-chlorobenzoic acid 
• 108-45-2 m-phenylenediamine 
• 99-60-5 2-chloro-4-nitrobenzoic acid 
• 25293-29-2 N-(3-amino-phenyl)-anthranilic acid 
• 1744-92-9 3-nitro-9,10-dihydroacridin-9-one 

Downstream Products

• 6269-27-8 3-chloroacridin-9(10H)-one 
• 581-29-3 acridin-3-ylamine 
• 129821-08-5 3-ATA 
• 776299-28-6 3-(p-acetylaminobenzenesulphonylamino)-acridone 
• 676456-14-7 3-(p-aminobenzenesulphonylamino)acridone 
• 80265-47-0 2-(2,5-Dioxo-imidazolidin-1-yl)-N-[9-(4-methanesulfonylamino-2-methoxy-phenylamino)-acridin-3-yl]-acetamide; hydrochloride 
• 80265-48-1 N-{4-[3-(2,5-Dioxo-imidazolidin-1-yl)-acridin-9-ylamino]-3-methoxy-phenyl}-methanesulfonamide; hydrobromide 

Relevant academic research and scientific papers

New sulphonamides with acridinic nucleus

Twelve new sulphonamides with acridonic and acridinic nucleus were synthesized, in which the sulphonamidic group appears in positions 1, 2, 3 and 4. We also obtained the corresponding acridanes, but we did not isolate them. We proved that in the case of 2-nitroacridone synthesis, by ring closure of 4-nitrodiphenylamine-2-carboxylic acid, working in the presence of sulphuric acid, sulphonation takes place. To reduce some nitroacridones we used hydrazine hydrate in the presence of Ni from formiate and Ni Raney, a method not yet mentioned in the literature for compounds of this class, and which presents many advantages. We proved that sulphonamides with acridonic nucleus can be transformed into the corresponding acridines, by reduction with Na-amalgam. The studied new substances show a noteworthy activity against microorganisms.

Inhibition of Cryptosporidium parvum in vitro by 9-(alkylthio)acridine derivatives

The synthesis of several acridinic thioethers is described. Compounds prepared were tested in vitro as potential drugs against the opportunistic infection known as cryptosporidiosis. With a view to predict activity, the quantitative structure-activity relationships were investigated. Correlations between experimental data and either log P or pKa are discussed.

Structure-trypanodical activity relationships

A set of 9-thioalkylacridinones, has been prepared and investigated' in vitro' against T. cruzi. Structure-antiparasitic activity relationships are detailed with a view to identify the major structural parameters for the activity under consideration.