129822-38-4

Usage

Uses

Used in Pharmaceutical Industry:
(3-FLUORO-2-METHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER is used as an intermediate in the synthesis of various pharmaceuticals for its potential to contribute to the development of new drugs.
Used in Agrochemical Industry:
(3-FLUORO-2-METHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER is used as a potential pesticide and insecticide, leveraging its chemical properties to control or kill pests in agricultural settings.
Used in Chemical Research and Development:
(3-FLUORO-2-METHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER is utilized in the research and development of new chemical substances and materials, serving as a building block for innovative applications across different industries.

InChI:InChI=1/C12H16FNO2/c1-8-9(13)6-5-7-10(8)14-11(15)16-12(2,3)4/h5-7H,1-4H3,(H,14,15)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 443-86-7 3-fluoro-2-methylaniline 

Downstream Products

• 138343-92-7 (2-tert-Butoxycarbonylamino-6-fluoro-phenyl)-acetic acid 
• 138343-94-9 4-fluoro-1,3-dihydro-2H-indol-2-one 
• 129822-45-3 tert-butyl 4-fluoro-1H-indole-1-carboxylate 
• 1260383-51-4 4-fluoro-2-methyl-1H-indole 
• 1383976-61-1 tert-butyl [3-fluoro-2-(2-oxopropyl)phenyl]carbamate 

Relevant academic research and scientific papers

NOVEL PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS

The present invention relates to novel chemical compounds derived from pyrimidines, to the method for preparing same, to the novel intermediates obtained, to the use thereof as drugs, to the pharmaceutical compositions containing same, and to the therapeutic use thereof as AKT inhibitors.

Process for the preparation of indolin-2-one derivatives useful as PR modulators

Processes for dialkylating indolinones, specifically indolin-2-ones are provided. The processes for dialkylating an indolin-2-one include performing the dialkylation in the presence of at least 2 equivalents of a first base, a second base containing at le

Preparation of indoles and oxindoles from N-(tert-butoxycarbonyl)-2-alkylanilines

Treatment of dilithiated N-(tert-butoxycarbonyl)anilines 1 with dimethylformamide or carbon dioxide furnishes intermediates 3, 5, that are easily converted to N-(tert-butoxycarbonyl)indoles 4 and oxindoles (indol-2(3H)-ones, 7), respectively. Condensation of dilithiated 1 with N-methoxy-N-methylamides provides ketones 9 which are cyclized upon trifluoroacetic acid treatment to either 2-substituted 1-(tert-butoxycarbonyl)indoles 10 or 2-substituted indoles 11 depending on the reaction time. This general methodology has been applied to efficient synthesis of 1,2-alkyl-bridged indoles 12, 1,3,4,5-tetrahydrobenz[c,d]indole (16), 2a,3,4,5-tetrahydrobenz[c,d]indol-2(1H)-one (18), and 1-(tert-butoxycarbonyl)1H-pyrrolo[2,3-b]pyridine (21).