129865-52-7

Basic information

• Product Name: 2-PIPERIDIN-1-YL-THIAZOLE-5-CARBALDEHYDE
• Synonyms: 2-PIPERIDINOTHIAZOLE-5-CARBOXALDEHYDE;2-PIPERIDINO-1,3-THIAZOLE-5-CARBALDEHYDE;2-PIPERIDIN-1-YL-THIAZOLE-5-CARBALDEHYDE;2-Piperidin-1-yl-1,3-thiazole-5-carboxaldehyde 97%;2-Piperidin-1-yl-1,3-thiazole-5-carboxaldehyde;2-(1-Piperidinyl)thiazole-5-carboxaldehyde;2-Piperidin-1-yl-1,3-thiazole-5-carboxaldehyde97%;2-piperidin-1-yl-1,3-thiazole-5-carbaldehyde
• CAS NO: 129865-52-7
• Molecular Formula: C₉H₁₂N₂OS
• Molecular Weight: 196.27
• Mol File: 129865-52-7.mol

Chemical Properties

• Melting Point: 48.5-49.5°C
• Boiling Point: 342 °C at 760mmHg
• Flash Point: 160.6 °C
• Appearance: /
• Density: 1.257 g/cm³
• Vapor Pressure: 7.76E-05mmHg at 25°C
• Refractive Index: 1.612
• PKA: 4.67±0.10(Predicted)
• CAS DataBase Reference: 2-PIPERIDIN-1-YL-THIAZOLE-5-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PIPERIDIN-1-YL-THIAZOLE-5-CARBALDEHYDE(129865-52-7)
• EPA Substance Registry System: 2-PIPERIDIN-1-YL-THIAZOLE-5-CARBALDEHYDE(129865-52-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 129865-52-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
2-PIPERIDIN-1-YL-THIAZOLE-5-CARBALDEHYDE is utilized as a key building block in the synthesis of various bioactive molecules, contributing to the development of new drugs. Its unique structure and reactivity allow for the creation of pharmaceutical intermediates that can be further modified to enhance their therapeutic properties.
Used in Agrochemical Development:
In the agrochemical industry, 2-PIPERIDIN-1-YL-THIAZOLE-5-CARBALDEHYDE serves as a precursor for the synthesis of new agrochemicals, potentially leading to the discovery of novel compounds with improved efficacy and selectivity in crop protection and pest management.
Used as a Reagent in Organic Synthesis:
2-PIPERIDIN-1-YL-THIAZOLE-5-CARBALDEHYDE is employed as a reagent in chemical reactions, facilitating the synthesis of complex organic compounds. Its structural features enable it to participate in a variety of organic transformations, broadening its utility in the synthesis of diverse organic molecules.

InChI:InChI=1/C9H12N2OS/c12-7-8-6-10-9(13-8)11-4-2-1-3-5-11/h6-7H,1-5H2

Upstream product

• 110-89-4 piperidine 
• 95453-58-0 2-chloro-1,3-thiazole-5-carbaldehyde 
• 3034-52-4 2-chlorothiazole 
• 2591-86-8 N-Formylpiperidine 
• 4175-70-6 2-(piperidin-1-yl)thiazole 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 477868-70-5 2-((2-(piperidin-1-yl)thiazol-5-yl)methylene)malononitrile 

Relevant articles and documents

Influence of thiazole regioisomerism on second-order nonlinear optical chromophores

Two series of matched and mismatched donor-thiazole-acceptor chromophores have been synthesized to disclose the role that the orientation of the thiazole ring plays on their second-order nonlinear optical (NLO) properties. Whereas previous theoretical stu

BENZOXAZOLE DERIVATIVES

It is intended to provide a benzoxazole derivative or a pharmaceutically acceptable salt or solvate thereof which is useful in the early diagnosis of a conformation disease; a composition or a kit containing the same for diagnosing a conformation disease; a medical composition for ttreating and/or preventing a conformation disease; and so on.

An Easy General Synthesis of 2-(N,N-Dialkylamino)thiazol-5-yl Aldehydes and Ketones

Reaction between 2-chloro-5-thiazolyl-lithium and N,N-dialkylformamides or amides gave 2-N,N-dialkylaminothiazol-5-yl aldehydes or ketones on quenching with water.Quenching with acid gave 2-chlorothiazole-5-yl aldehydes or ketones, from which chloride was easily displaced by free amines.