130407-16-8

Basic information

• Product Name: 1-methyl-1,2,3,6-tetrahydrostilbazole
• Synonyms: 1-methyl-1,2,3,6-tetrahydrostilbazole
• CAS NO: 130407-16-8
• Molecular Formula: C₁₄H₁₇N
• Molecular Weight: 199.29
• Mol File: 130407-16-8.mol

Chemical Properties

• Boiling Point: 320.5°C at 760 mmHg
• Flash Point: 134.3°C
• Appearance: /
• Density: 1.066g/cm³
• Vapor Pressure: 0.000316mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: 1-methyl-1,2,3,6-tetrahydrostilbazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-1,2,3,6-tetrahydrostilbazole(130407-16-8)
• EPA Substance Registry System: 1-methyl-1,2,3,6-tetrahydrostilbazole(130407-16-8)

Safety Data

• Hazardous Substances Data: 130407-16-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H17N/c1-15-11-9-14(10-12-15)8-7-13-5-3-2-4-6-13/h2-9H,10-12H2,1H3/b8-7+

Upstream product

• 5097-93-8 trans-4-styrylpyride 
• 74-88-4 methyl iodide 
• 20111-34-6 (E)-1-methyl-4-(2-phenylethenyl)pyridinium iodide 
• 108-89-4 picoline 
• 100-52-7 benzaldehyde 

Downstream Products

• 143888-17-9 (E)-1-methyl-4-(2-phenylethenyl)-1,2,3,6-tetrahydropyridine N-oxide 

Relevant articles and documents

Synthesis of Novel MPTP Analogs as Potential Monoamine Oxidase B (MAO-B) Inhibitors

The nigrostratial toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is an excellent substrate and a weak inactivator of the flavoenzyme monoamine oxidase B (MAO-B).In an attempt to develop novel mechanism-based inactivators of MAO-B, we have synth

Flexible N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogues: Synthesis and monoamine oxidase catalyzed bioactivation

Eighteen analogues of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were synthesized and evaluated as substrates of monoamine oxidase. In general, the flexible analogues, characterized by the presence of a methylene (or ethylene) bridge between the aryl/heteroaryl and tetrahydropyridyl moieties, were better substrates of the enzyme than the conformationally restricted MPTP. It is suggested that the increased oxidative activity of these flexible analogues reflects enhanced binding due to the ability of the C-4-aryl/heteroaryl substituent to gain access to a hydrophobic pocket within the substrate binding site.