- Encapsulated reagents for nitrosation
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(Matrix presented) A novel class of stable, mild, and size-shape-selective nitrosating agents for secondary amides is introduced. These are based on reversible entrapment and release of reactive nitrosonium species by calix[4]arenes. The NO+ encapsulation controls the reaction selectivity.
- Zyryanov, Grigory V.,Rudkevich, Dmitry M.
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p. 1253 - 1256
(2007/10/03)
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- The Selective N-Monoalkylation of Amides with Alkyl Halides in the Presence of Alumina and KOH
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The effects of alumina impregnated with KOH (KOH/Al2O3) and a mixture of alumina and powdered KOH (KOH+Al2O3) have been examined using the alkylation of benzamide under various conditions.In each case, alkylation occurs exclusively in the pores of the alumina, the extent depending upon the alumina-pore size.For both yield and selectivity for N-monoalkylation, KOH+Al2O3 is superior to KOH/Al2O3.Dioxane is the best of the solvents employed.It is proposed that, in dioxane, an enolate-like species, PhC(O-K+)=NR', exists as stable ion pair aggregates, which are true reactants in the pore.This method, using KOH/Al2O3 or KOH+Al2O3, has been applied to N-alkylation of the other amides, giving the N-monoalkylated products in substantial yields with extremely high selectivities. 2-Phenylacetamide is regioselectively N-monoalkylated in high yields.This regioselectivity is explained in terms of steric hindrance.
- Sukata, Kazuaki
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p. 838 - 843
(2007/10/02)
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- Organic compounds substituted heptadeca-5,9- and 5,10-dienoic acid
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The present invention provides novel substituted heptadeca-5,9- and 5,10-dienoic acid and similar fatty acid compounds which are derivatives of certain prostaglandins and are potent thromboxane A2 inhibitors. By virtue of this pharmacological property, they represent useful pharmacological agents for a wide variety of purposes.
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