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8-Bromo-5,6-difluoro-2-methylquinoline is a quinoline derivative, a heterocyclic compound characterized by a quinoline ring system with a bromine atom and two fluorine atoms. The methyl group at position 2 adds to its structural complexity, making it a potentially valuable building block for the synthesis of bioactive molecules in medicinal chemistry and other fields.

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  • 131190-82-4 Structure
  • Basic information

    1. Product Name: 8-BROMO-5,6-DIFLUORO-2-METHYLQUINOLINE
    2. Synonyms: 8-BROMO-5,6-DIFLUORO-2-METHYLQUINOLINE
    3. CAS NO:131190-82-4
    4. Molecular Formula: C10H6BrF2N
    5. Molecular Weight: 258.0621464
    6. EINECS: 1533716-785-6
    7. Product Categories: N/A
    8. Mol File: 131190-82-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 299.831 °C at 760 mmHg
    3. Flash Point: 135.133 °C
    4. Appearance: /
    5. Density: 1.637 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 8-BROMO-5,6-DIFLUORO-2-METHYLQUINOLINE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 8-BROMO-5,6-DIFLUORO-2-METHYLQUINOLINE(131190-82-4)
    11. EPA Substance Registry System: 8-BROMO-5,6-DIFLUORO-2-METHYLQUINOLINE(131190-82-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 131190-82-4(Hazardous Substances Data)

131190-82-4 Usage

Uses

Used in Medicinal Chemistry:
8-Bromo-5,6-difluoro-2-methylquinoline is used as a building block for the development of pharmaceuticals due to its unique structure and properties, which can be utilized in the synthesis of various bioactive molecules.
Used in Agrochemicals:
8-Bromo-5,6-difluoro-2-methylquinoline is used as a building block in the development of agrochemicals, potentially contributing to the creation of new pesticides or other agricultural chemicals.
Used in Organic Synthesis:
8-Bromo-5,6-difluoro-2-methylquinoline is used as a reagent or intermediate in organic synthesis, facilitating the creation of complex organic compounds for various applications.
Note: The specific uses and properties of 8-Bromo-5,6-difluoro-2-methylquinoline would need to be further studied and characterized through research to fully understand its potential applications across different industries.

Check Digit Verification of cas no

The CAS Registry Mumber 131190-82-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,1,9 and 0 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 131190-82:
(8*1)+(7*3)+(6*1)+(5*1)+(4*9)+(3*0)+(2*8)+(1*2)=94
94 % 10 = 4
So 131190-82-4 is a valid CAS Registry Number.

131190-82-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 8-BROMO-5,6-DIFLUORO-2-METHYLQUINOLINE

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:131190-82-4 SDS

131190-82-4Relevant articles and documents

Synthesis process of S-(-)-nadifloxacin chiral intermediate

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Paragraph 0014; 0058-0060; 0063-0065; 0068-0070; 0073-0077, (2021/10/27)

The invention discloses a synthesis process of an S-(-)-nadifloxacin chiral intermediate, and belongs to the technical field of chemical pharmacy. The synthesis process comprises the following steps: 1, synthesizing an intermediate 1; and 2, synthesizing the S-(-)-chiral intermediate. R binaphthylenediamine is used as a matrix of a chiral ligand, epoxy polysilsesquioxane is grafted on a molecule of N-Boc-L-histidine to form the chiral ligand, on one hand, the ee value is increased by utilizing the chiral characteristic of N-Boc-L-histidine, and on the other hand, the ee value is increased by utilizing the characteristics of nanoscale size and solubility of the epoxy polysilsesquioxane, so that the solubility of the catalyst is increased, and the catalyst can be mixed with the reactant in the nanometer size so as to improve the catalytic performance of the chiral catalyst and improve the reaction yield, such that the chiral ligand and the metal ruthenium are subjected to coordination to form the chiral catalyst so as to provide the good chiral amplification effect;.

Synthesis, antibacterial activities, mode of action and acute toxicity studies of new oxazolidinone-fluoroquinolone hybrids

Liu, Lili,Shao, Liping,Li, Jing,Cui, Haifeng,Li, Bing,Zhou, Xuzheng,Lv, Pengyue,Zhang, Jiyu

, (2019/05/01)

To combat bacterial resistance, a series of new oxazolidinone-fluoroquinolone hybrids have been synthesized and characterized. All synthetic hybrids were preliminarily evaluated for their in vitro antibacterial activities against 6 standard strains and 3 clinical isolates. The majority of hybrids displayed excellent activities against Gram-positive bacteria, but limited activities against Gram-negative bacteria. Hybrids OBP-4 and OBP-5 were found to be the most promising compounds. Further, in vitro antibacterial activities, mode of action and acute toxicity in mice of hybrids OBP-4 and OBP-5 were investigated. Hybrids OBP-4 and OBP-5 exhibited potent activities against Gram-positive bacteria, including drug-resistant strains. Correspondingly, studies on the mode of action of hybrids OBP-4 and OBP-5 indicated a strong inhibitory activity on protein synthesis by binding the active site of 50S subunit, but a weak inhibitory action on DNA synthesis. In addition, LD50 values of hybrids OBP-4 and OBP-5 in the acute oral toxicity were larger than 2000 mg/kg, suggesting a good safety profile.

DIPHENYLMETHANE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS

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Page/Page column 44, (2008/06/13)

The instant invention provides compounds of Formula I which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents.

DIPHENYL SUBSTITUTED CYCLOALKANES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE

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Page/Page column 55, (2008/06/13)

The instant invention provides compounds of Formula (I) which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

A practical synthesis of (S)-(-)-nadifloxacin: Novel acid-catalyzed racemization of tetrahydroquinaldine derivative

Hashimoto, Koji,Okaichi, Yoshihiko,Nomi, Daisuke,Miyamoto, Hisashi,Bando, Masahiko,Kido, Masaru,Fujimura, Tsutomu,Furuta, Takuya,Minamikawa, Jun-Ichi

, p. 642 - 645 (2007/10/03)

(S)-(-)-Nadifloxacin [(S)-(-)-9-fluro-6,7-dihydro-8-(4-hyroxy-1- piperidyl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, (S)- (-)-OPC-7251], an antibacterial agent, was synthesized from (S)-(-)-5,6- difluoro-2-methyl-1,2,3,4-tetrahydroquinoline (DFTQ), which was prepared by the optical resolution of racemic DFTQ with 2,3-di-O-benzoyl-L-tartaric acid. Racemization of the undesired enantiomer [(R)-(+)-DFTQ] was studied in the presence of various acids and the best result was obtained in the case of methanesulfonic acid. The absolute configuraton of (-)-nadifloxacin was determined as S by X-ray crystallographic analysis.

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