13126-07-3Relevant articles and documents
Convenient green preparation of dipeptides using unprotected α-amino acids
Ezawa, Tetsuya,Jung, Seunghee,Kawashima, Yuya,Noguchi, Takuya,Imai, Nobuyuki
, p. 75 - 83 (2017/01/10)
Dipeptides and amides were obtained in high yields from N-carbobenzyloxy α-amino acids and 3-phenylpropanoic acid with unprotected α-amino acids via the corresponding mixed carbonic carboxylic anhydrides using ethyl chloroformate and triethylamine by an ecological and convenient method in which the protection of C-terminals is not needed.
Convenient synthesis of C-terminal di- and tri-peptide amides from N-protected dipeptidoylbenzotriazoles
Celik, Ilhami,Abdel-Fattah, Ashraf A.A.
experimental part, p. 4923 - 4929 (2009/10/09)
N-Protected dipeptidoylbenzotriazoles react with aqueous ammonia to give dipeptide primary amides (77-98%) and with N-unprotected α-amino amides to afford tripeptide primary amides (82-86%).
Design and Synthesis of Enkephalin Analogues: Part I - Synthesis of Met-Enkephalin Alkylamides with Enhanced Analgesic Potency
Dhotre, B. J.,Chaturvedi, S.,Mathur, K. B.
, p. 828 - 833 (2007/10/02)
Synthesis of a series of alkylamides of Met-enkephalin has been achieved employing the key intermediate Boc-Tyr-Gly-Gly-Phe-Met-ONBzl (IV), obtained from Met-ONBzl by treatment with appropiate Nα-Boc-amino acid-2,4,5-trichlorophenyl esters in a