769922-77-2

Upstream product

• 95-14-7 1,2,3-Benzotriazole 
• 1161-13-3 N-Cbz-L-Phe 
• 52641-32-4 N-benzyloxycarbonyl-L-phenylalanyl chloride 

Downstream Products

• 3338-39-4 N-benzyloxycarbonyl-L-phenylalanyl-L-alanine 
• 13123-00-7 (2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanoyl)amino]-3-methylbutanoic acid 
• 860-55-9 (2S)-2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanoyl)amino]-3-hydroxypropanoic acid 
• 13122-91-3 N-benzyloxycarbonyl-L-phenylalanyl-L-phenylalanine 
• 2075-55-0 S-phenyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanethioate 
• 120418-34-0 octadecyl (S)-2-[(benzyloxycarbonyl)amino]-3-phenylpropanoate 
• 98210-62-9 (1R,2R,5R)-2-isopropyl-5-methylcyclohexyl (S)-2-[(benzyloxycarbonyl)amino]-3-phenylpropanoate 
• 1006722-12-8 C₄₃H₆₀N₂O₁₂ 
• 6372-14-1 N-((benzyloxy)carbonyl)-L-phenylalaninol 
• 32949-41-0 (S)-2-((S)-2-benzyloxycarbonylamino-3-phenyl-propionylamino)-5-guanidinopentanoic acid 
• 6464-78-4 (S)-2-((S)-2-benzyloxycarbonylamino-3-phenylpropanoylamino)-5-nitroguanidinopentanoic acid 
• 214122-05-1 (4S)-4-[[(benzyloxy)carbonyl]amino]-3-oxo-5-phenyl-2-triphenylphosphoranylidene-pentanenitrile 
• 136226-19-2 C₃₉H₃₆NO₅P 
• 1194481-48-5 Cbz-L-Phe-AOGly-OH 

Relevant academic research and scientific papers

Design and synthesis of a new series of 3,5-disubstituted-1,2,4-oxadiazoles as potential colchicine binding site inhibitors: Antiproliferative activity, molecular docking, and SAR studies

The development of anticancer compounds targeting the colchicine-binding site of tubulin, termed colchicine-binding site inhibitors (CBSIs) is a promising research area for pharmaceutical companies and research institutes. A series of 3,5-disubstituted 1,

A simple and versatile method to synthesize N-acyl-benzotriazoles

An efficient method for the synthesis of N-acyl-benzotriazoles from a wide variety of protected amino acids, as well as from compounds frequently used in drug discovery such as biotin and N-Fmoc polyethylene glycol, has been developed. The reaction of car

Photoredox Alkenylation of Carboxylic Acids and Peptides: Synthesis of Covalent Enzyme Inhibitors

The synthesis of vinyl sulfones and (α,β-unsaturated) nitriles from carboxylic acids was realized through oxidative decarboxylation with 1,4-dicyanoanthracene as an organic photoredox catalyst. Various types of C-radicals are generated and used to construct three different classes of potential covalent protease inhibitors. The procedure is functional group tolerant and applicable to natural products and druglike scaffolds. It may serve for the rapid construction of screening candidates as demonstrated by a three-step synthesis of the known protease inhibitor K11777.

Synthesis, molecular docking and anticancer studies of peptides and iso-peptides

Chiral peptides and iso-peptides were synthesized in excellent yield by using benzotriazole mediated solution phase synthesis. Benzotriazole acted both as activating and leaving group, eliminating frequent use of protection and subsequent deprotection. The procedure was based on the hypothesis that epimerization should be suppressed in solution due to a faster coupling rate than SPPS. All the synthesized peptides complied with Lipinski's Ro5 except for the rotatable bonds. Inhibition of cell proliferation of cancer cell lines is one of the most commonly used methods to study the effectiveness of any anticancer agents. Synthesized peptides and iso-peptides were tested against three cancer cell lines (MCF-7, MDA-MB 231) to determine their anti-proliferative potential. NFkB was also determined. Molecular docking studies were also carried out to complement the experimental results.

Chemical modification of oximes with N-protected amino acids

The modification of oximes, including 5α-steroids, with N-protected amino acids, in solution phase, using benzotriazole methodology is reported.

Synthesis and evaluation of radioiodinated acyloxymethyl ketones as activity-based probes for cathepsin B

Dipeptidyl (acyloxy)methyl ketones (AOMKs) were functionalized with different iodine-containing prosthetic groups to generate a library of candidate cathepsin B probes. Compound 23a, (S)-20-[(S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanamido]-1-(4-iod

Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates

Amino acid conjugates of quinolone, metronidazole and sulfadiazine antibiotics were synthesized in good yields using benzotriazole methodology. All the conjugates were screened for their antibacterial activity using methods adapted from the Clinical and L

Non-phosgene route to unsymmetrical ureas from N-Cbz-α-amino acid amides

A convenient method toward the synthesis of α-amino acid-derived unsymmetrical ureas 2 is described herein. This route involves an interesting rearrangement of amides of N-Cbz-α-amino acids 1, which presumably entails the intermediacy of hydantoins that is followed by hydrolysis to afford unsymmetrical ureas 2 in quantitative yields and high purity.

Green, catalyst-free synthesis of mesalazine conjugates

A greener protocol for the synthesis of mesalazine conjugates is reported. Mesalazine conjugates are prepared in high yields by a one-pot reaction of mesalazine and aminoacyl/peptidoylbenzotriazoles in water under microwave irradiation. Georg Thieme Verlag Stuttgart New York.