- Synthesis of the ABC- and D-ring systems of the indole alkaloid ambiguine G
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A glycine Schiff base Michael addition is used in sequence with free radical-mediated aryl amination to ultimately arrive at the ambiguine G ABC-tricycle convergently. Additionally, thermal Diels-Alder cycloaddition of β-chloromethacrolein with Cohen's di
- Chandra, Aroop,Viswanathan, Rajesh,Johnston, Jeffrey N.
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- SEROTONIN RECEPTOR MODULATORS
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Compounds, compositions, and methods are provided for dual partial agonism of serotonin 5-HT7 and 5-HT1A receptors. The enantiomerically pure 5-phenyl-2-aminotetralin (5-PAT) compounds can be used to treat or prevent substance use disorder, opioid use disorder, addiction, anxiety, psychosis, depression, autism spectrum disorder, fragile X syndrome, neurological disorders, neuropsychiatric disorders, repetitive behaviors, movement disorders, compulsions, tics, pain disorders, vasospastic disorders, migraine headache, seizures, epilepsy, social anxiety, addiction withdrawal, drug withdrawal, drug abuse, alcoholism, eating disorders, general inflammation disorders, miosis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, and gastrointestinal disorders.
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- COMPOUNDS AND METHODS FOR MODULATING SEROTONIN RECEPTORS IN THE PERIPHERY
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This invention relates to, in part, compositions and methods that are useful for, inter alia, the treatment of various diseases, including those linked to binding at a serotonin receptor in the Gl tract.
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- SEROTONIN RECEPTOR-TARGETING COMPOUNDS AND METHODS
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This invention relates to, in part, compositions and methods that are useful for, inter alia, the treatment of various diseases, including those linked to binding at a serotonin receptor. The compositions include chiral tetrahydronaphthalen-2-amine deriva
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- Structure-activity relationship of linear peptide Bu-His-DPhe-Arg-Trp-Gly-NH2 at the human melanocortin-1 and -4 receptors: Histidine substitution
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Systematic substitution of His6 residue using non-selective hMC4R pentapeptide agonist (Bu-His6-DPhe7-Arg8-Trp9-Gly 10-NH2) as the template led to the identification of Bu-Atcsu
- Cheung, Adrian Wai-Hing,Danho, Waleed,Swistok, Joseph,Qi, Lida,Kurylko, Grazyna,Rowan, Karen,Yeon, Mitch,Franco, Lucia,Chu, Xin-Jie,Chen, Li,Yagaloff, Keith
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p. 133 - 137
(2007/10/03)
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- Selective cyclic peptides with melanocortin-4 receptor (MC4-R) agonist activity
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Peptides cyclized via disulfide or lactam bridges having melanocortin-4 receptor (MC4-R) agonist activity useful for treatment of obesity.
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- Selective linear peptides with melanocortin-4 receptor (MC4-R) agonist activity
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Peptides of formulae I, II and III selectively activate melanocortin-4 (MC-4) receptor activity.
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- Bicyclic amine derivatives and their use as anti-psychotic agents
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This invention relates to compounds of formula (I) STR1 which are useful as modulators of D3 receptors, in particular as antipsychotic agents.
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- 1,2,3,4-tetrahydronaphthalene compounds
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R1 and R2 form, with the carbon atoms to which they are attached, cyclopentane or cyclohexane, R3 represents hydroxyl, linear or branched (C1 -C6) alkoxy or unsubstituted or substituted amino,
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