132095-53-5

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-2-tetralone is used as a reagent for the preparation of 2-aminotetralins, which are known for their high affinity and selectivity for the dopamine D3 receptor. This application is particularly relevant in the development of drugs targeting the dopaminergic system, which plays a crucial role in various neurological and psychiatric disorders, such as schizophrenia, Parkinson's disease, and addiction.

InChI:InChI=1/C10H9BrO/c11-10-3-1-2-7-6-8(12)4-5-9(7)10/h1-3H,4-6H2

Upstream product

• 74-85-1 ethene 
• 1878-67-7 3-Bromophenylacetic acid 
• 365555-15-3 4-(2-bromophenyl)-1-diazobutan-2-one 
• 103-80-0 phenylacetyl chloride 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 92013-31-5 5-bromotetralol 
• 68449-30-9 5-bromo-1-tetralone 
• 87779-57-5 bromo-5 dihydro-3,4 naphthalene 
• 15115-58-9 3-(2-bromophenyl)propionic acid 
• 90725-40-9 3-(2-bromophenyl)propanoyl chloride 

Downstream Products

• 1221135-69-8 C₁₈H₁₈BrNO 
• 183543-37-5 5-Cyano-N-(4-(4-phenylbenzoylamino)butyl)-2-(R,S)-propylamino-1,2,3,4-tetrahydronaphthalene 
• 183543-24-0 5-Bromo-N-(4-(4-phenylbenzoylamino)butyl)-2-(R,S)-propylamino-1,2,3,4-tetrahydronaphthalene 

Relevant academic research and scientific papers

Synthesis of the ABC- and D-ring systems of the indole alkaloid ambiguine G

A glycine Schiff base Michael addition is used in sequence with free radical-mediated aryl amination to ultimately arrive at the ambiguine G ABC-tricycle convergently. Additionally, thermal Diels-Alder cycloaddition of β-chloromethacrolein with Cohen's di

SEROTONIN RECEPTOR MODULATORS

Compounds, compositions, and methods are provided for dual partial agonism of serotonin 5-HT7 and 5-HT1A receptors. The enantiomerically pure 5-phenyl-2-aminotetralin (5-PAT) compounds can be used to treat or prevent substance use disorder, opioid use disorder, addiction, anxiety, psychosis, depression, autism spectrum disorder, fragile X syndrome, neurological disorders, neuropsychiatric disorders, repetitive behaviors, movement disorders, compulsions, tics, pain disorders, vasospastic disorders, migraine headache, seizures, epilepsy, social anxiety, addiction withdrawal, drug withdrawal, drug abuse, alcoholism, eating disorders, general inflammation disorders, miosis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, and gastrointestinal disorders.

COMPOUNDS AND METHODS FOR MODULATING SEROTONIN RECEPTORS IN THE PERIPHERY

This invention relates to, in part, compositions and methods that are useful for, inter alia, the treatment of various diseases, including those linked to binding at a serotonin receptor in the Gl tract.

SEROTONIN RECEPTOR-TARGETING COMPOUNDS AND METHODS

This invention relates to, in part, compositions and methods that are useful for, inter alia, the treatment of various diseases, including those linked to binding at a serotonin receptor. The compositions include chiral tetrahydronaphthalen-2-amine deriva

Structure-activity relationship of linear peptide Bu-His-DPhe-Arg-Trp-Gly-NH2 at the human melanocortin-1 and -4 receptors: Histidine substitution

Systematic substitution of His6 residue using non-selective hMC4R pentapeptide agonist (Bu-His6-DPhe7-Arg8-Trp9-Gly 10-NH2) as the template led to the identification of Bu-Atcsu

Selective cyclic peptides with melanocortin-4 receptor (MC4-R) agonist activity

Peptides cyclized via disulfide or lactam bridges having melanocortin-4 receptor (MC4-R) agonist activity useful for treatment of obesity.

Selective linear peptides with melanocortin-4 receptor (MC4-R) agonist activity

Peptides of formulae I, II and III selectively activate melanocortin-4 (MC-4) receptor activity.

Bicyclic amine derivatives and their use as anti-psychotic agents

This invention relates to compounds of formula (I) STR1 which are useful as modulators of D3 receptors, in particular as antipsychotic agents.

1,2,3,4-tetrahydronaphthalene compounds

R1 and R2 form, with the carbon atoms to which they are attached, cyclopentane or cyclohexane, R3 represents hydroxyl, linear or branched (C1 -C6) alkoxy or unsubstituted or substituted amino,