132259-55-3

Basic information

• Product Name: 2-Piperidinecarboxamide,2-methyl-,(R)-(9CI)
• Synonyms: 2-Piperidinecarboxamide,2-methyl-,(R)-(9CI)
• CAS NO: 132259-55-3
• Molecular Formula: C7H14N2O
• Molecular Weight: 142.2
• Product Categories: AMIDE
• Mol File: 132259-55-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Piperidinecarboxamide,2-methyl-,(R)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Piperidinecarboxamide,2-methyl-,(R)-(9CI)(132259-55-3)
• EPA Substance Registry System: 2-Piperidinecarboxamide,2-methyl-,(R)-(9CI)(132259-55-3)

Safety Data

• Hazardous Substances Data: 132259-55-3(Hazardous Substances Data)

Upstream product

• 132235-39-3 (1'R,2R,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-piperidine carboxamide 
• 55386-67-9 2-methyl-3,4,5,6-tetrahydropyridine-1-oxide 
• 132235-35-9 (1'R,2R,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-piperidinecarbonitrile 

Downstream Products

• 105141-61-5 (R)-2-methyl-2-piperidinecarboxylic acid 

Relevant articles and documents

Preparation and Use of Chloromethyl (-)-Menthyl Ether in the Synthesis of Optically Pure α-Branched α-Amino Nitriles

The synthesis of optically pure chloromethyl (-)-menthyl ether (2b) and its use in the synthesis of di-(-)-menthyl acetal (-)-menthyl (+)-menthyl acetals are described.The diastereomeric mixed acetals 7a,b and 8a,b are easily obtainable from the nitrones 5 and 6, KCN and 2b.The mixture of diastereomers are separated into the pure components 7a, 7b and 8a, 8b by simple silica gel column chromatography.Hydrolysis of these products (H2O2/Na2CO3, ultrasound) followed by N-O cleavage affords the heterocyclic α-methyl-α-amino amides 11a, 11b and 12a, 12b.These are subsequently hydrolyzed to give the corresponding α-methyl-α-amino acids with S and R configuration, respectively.