55386-67-9

Upstream product

• 99687-80-6 2-methyl-1-hydroxypiperidine 
• 10226-30-9 6-chloro-2-hexanone 
• 109-05-7 2-Methylpiperidin 
• 80-62-6 methacrylic acid methyl ester 

Downstream Products

• 127983-46-4 cis-6-methyl-8-phenyl-9-oxa-1-azabicyclo<4.3.0>nonane 
• 124525-91-3 (3aR,3bS,8aS)-3b-Methyl-2-phenyl-hexahydro-8-oxa-2,7a-diaza-cyclopenta[a]indene-1,3-dione 
• 132235-37-1 (1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-piperidinecarbonitrile 
• 132235-35-9 (1'R,2R,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-piperidinecarbonitrile 
• 124525-95-7 (3R,3aS)-3-Benzenesulfonyl-3a-methyl-hexahydro-isoxazolo[2,3-a]pyridine 
• 109-05-7 2-Methylpiperidin 
• 155371-20-3 3a-methyl-2-phenyl-4,5,6,7-tetrahydro-3aH-isoxazolo[2,3-a]pyridine-3-carbaldehyde 
• 131697-74-0 (2S,3aR)-8-Benzyl-3a-methyl-2-phenyl-hexahydro-isoxazolo[2,3-a]pyridin-8-ium; bromide 
• 132235-41-7 (1'R,2S,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-piperidine carboxamide 
• 132235-39-3 (1'R,2R,2'S,5'R)-1-<(2-isopropyl-5-methylcyclohexyl)oxymethoxy>-2-methyl-2-piperidine carboxamide 
• 105141-61-5 (R)-2-methyl-2-piperidinecarboxylic acid 
• 89115-95-7 (S)-2-Methyl-2-piperidinecarboxylic acid 
• 132259-55-3 (2R)-2-methyl-2-piperidinecarboxamide 
• 132235-44-0 (2S)-2-methyl-2-piperidinecarboxamide 

Relevant academic research and scientific papers

Strain-Release Driven Cycloadditions for Rapid Construction of Functionalized Pyridines and Amino Alcohols

This paper describes the development of a new variant of stereoselective strain-release driven reactions (formal homo [3 + 2] dipolar cycloadditions) which utilize housane (1) to construct functionalized amino alcohols and pyridine-substituted cyclopentanes in two to three steps from simple and easily available building blocks (nitrones and pyridine N-oxides respectively).

Gold Supported on Silica Catalyzes the Aerobic Oxidation of N,N-Disubstituted Hydroxylamines to Nitrones

A new method for the preparation of nitrones through the aerobic oxidation of the corresponding N,N-disubstituted hydroxylamines has been developed by exploring a new catalytic reactivity of gold supported on silica. The oxidation occurs under very mild c

Molybdenum oxide/bipyridine hybrid material {[MoO3(bipy)] [MoO3(H2O)]}n as catalyst for the oxidation of secondary amines to nitrones

The inorganic-organic hybrid material {[MoO3(bipy)][MoO 3(H2O)]}n (bipy = 2,2′-bipyridine) can be used as a water-tolerant catalyst for the oxidation of secondary amines under mild conditions using either urea hydrogen peroxide (UHP) or tert-butylhydroperoxide (TBHP) as the oxidant. Under optimized reaction conditions (2 mol % catalyst, 3-4 equiv TBHP, CH2Cl2 as the solvent, 40 °C), the corresponding nitrones were obtained with different efficiency depending on the nature of the cyclic or acyclic amine used.

Process for the preparation of amine oxides

The present invention provides a process for the preparation of amine oxide by reacting a tertiary or a secondary amine with hydrogen peroxide as an oxidant in the presence of a recyclable heterogeneous catalyst comprising a layered double hydroxide exchanged with an anion in the presence of an additive selected from the group consisting of benzonitrile, propionitrile, isoburyronitrile, benzamide and isobutyramide.

Two new methodologies for the deoxygenation and reduction of nitrones based on the use of lithium and DTBB (cat.)

A variety of nitrones undergo deoxygenation when treated with an excess of lithium powder and a catalytic amount of 4,4′-di-tert-butylbiphenyl (DTBB) (10 mol%) in THF at room temperature to give the corresponding imines. The Li/DTBB system, when combined with nickel(II) chloride dihydrate allows the reduction of a series of nitrones to secondary amines. The use of the deuterium oxide-containing nickel(II) salt transforms the starting nitrones to deuterated secondary amines.

Synthesis of nitrones using the methyltrioxorhenium/hydrogen peroxide system

Secondary amines are oxidized by the methyltrioxorhenium/hydrogen peroxide system to the corresponding nitrones in excellent yield. The results provide a further example of the parallel between the chemistry of this metal system and that of the dioxiranes.

Synthesis of nitrones by methyltrioxorhenium catalyzed direct oxidation of secondary amines

Oxidation of secondary amines catalyzed by methyltrioxorhenium (MTO) with H2O2 or urea-hydrogen peroxide complex (UHP) at room temperature gives the corresponding nitrones in good yields.

Oxidation of secondary amines to nitrones using urea-hydrogen peroxide complex (UHP) and metal catalysts

Secondary amines can be readily oxidized to the corresponding nitrones using urea-hydrogen peroxide complex (UHP) and metal catalysts in methanol at room temperature. Sodium tungstate is the most effective catalyst in several runs and common protecting groups are tolerated in these conditions.