132376-67-1

Basic information

• Product Name: (2E)-3-(1-BENZOFURAN-2-YL)ACRYLIC ACID
• Synonyms: RARECHEM BK HD 0006;(2E)-3-(1-BENZOFURAN-2-YL)ACRYLIC ACID;(2E)-3-(1-benzofuran-2-yl)acrylic (2E)-3-(1-Benzofuran-2-Yl)Acrylic Acid(WX610378)
• CAS NO: 132376-67-1
• Molecular Formula: C₁₁H₈O₃
• Molecular Weight: 188.18
• Mol File: 132376-67-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2E)-3-(1-BENZOFURAN-2-YL)ACRYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-(1-BENZOFURAN-2-YL)ACRYLIC ACID(132376-67-1)
• EPA Substance Registry System: (2E)-3-(1-BENZOFURAN-2-YL)ACRYLIC ACID(132376-67-1)

Safety Data

• Hazardous Substances Data: 132376-67-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(2E)-3-(1-BENZOFURAN-2-YL)ACRYLIC ACID is used as a building block for more complex molecules in organic synthesis. Its unique structure allows for the creation of a wide range of compounds with various applications.
Used in Pharmaceutical Research:
(2E)-3-(1-BENZOFURAN-2-YL)ACRYLIC ACID is used as a starting material in the development of new pharmaceutical compounds. Its biological activity and potential pharmacological properties make it a promising candidate for drug discovery.
Used in Materials Science:
(2E)-3-(1-BENZOFURAN-2-YL)ACRYLIC ACID is used in the development of organic electronic devices, dyes, and pigments due to its conjugated structure and potential for various applications in this field.
Used in Chemical Biology:
(2E)-3-(1-BENZOFURAN-2-YL)ACRYLIC ACID is used in chemical biology research to study its interactions with biological systems and to explore its potential as a therapeutic agent.
Used in Drug Development:
(2E)-3-(1-BENZOFURAN-2-YL)ACRYLIC ACID is used in the development of new drugs, particularly in the pharmaceutical industry, due to its biological activity and potential pharmacological properties.

Upstream product

• 141-82-2 malonic acid 
• 4265-16-1 2-formylbenzo[b]furan 
• 91909-84-1 ethyl 3-(benzo[b]furan-2-yl)propionate 
• 748752-63-8 (rac)-2-amino-3-benzofuran-2-yl-propionic acid 
• 125482-23-7 (E)-ethyl 3-(2-benzofuryl)acrylate 
• 271-89-6 1-benzofurane 
• 3199-61-9 ethyl coumarilate 
• 42974-19-6 benzo[b]furan-2-carbohydrazide 
• 76268-18-3 C₁₆H₁₄N₂O₄S 

Downstream Products

• 1075220-99-3 6-[(E)-2-(1-benzofuran-2-yl)ethenyl]-3-(4-bromophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1075220-97-1 6-[(E)-2-(1-benzofuran-2-yl)ethenyl]-3-(3-methylphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1075220-96-0 6-[(E)-2-(1-benzofuran-2-yl)ethenyl]-3-benzyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1075220-98-2 6-[(E)-2-(1-benzofuran-2-yl)ethenyl]-3-(4-methylphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 144829-19-6 dihydro-5-([2'-hydroxyphenyl]methyl)-2(3H)-furanone 
• 21683-86-3 3-(Benzofuran-2-yl)propionic acid 

Relevant articles and documents

Intramolecular acylative ring-switching reactions of 3-(tetrahydro-2′-furyl)propanoic acid derivatives to give butanolides: Mechanism and scope

The mechanisms by which dihydro-5-(3′-trifluoroacetoxypropyl)-2(3H)-furanone is formed when 3-(tetrahydro-2′- furyl)propanoic-trifluoroacetic mixed anhydride is treated with an acidic catalyst is defined, and routes to some potentially useful butanolide synthons are described.

One-pot synthesis of fused 2-pyridones from heteroarylacrylic acid via curtius rearrangement & microwave-assisted thermal electrocyclization

We investigated the one-pot synthesis of several fused 2-pyridone ring systems based on a Curtius rearrangement, followed by a microwave-assisted thermal electrocyclization of a 2-aza-6?-electron system including isocyanate. We synthesized seven heterocyclic compounds containing a fused 2-pyridone ring. In these results, the one-pot synthesis of fused 2-pyridone ring system 5 from (E)-acrylic acids 1 under microwave irradiation conditions was more effective than the conventional reaction conditions in terms of the yield and the reaction time.

Novel Bicyclic Pyridinones

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Synthesis of 3-substituted (6-[(e)-2-(1-benzofuran-2-yl)ethenyl][1,2,4] triazolo[3,4-b][1,3,4]thiadiazoles

The reaction of (2E)-3-(1-benzofuran-2-yl)-2-propenoic acid with 4-amino-5-R-1,2,4-triazole-3-thioles has been investigated. It has been established, that 6-[(E)-2-(1-benzofuran-2-yl)ethenyl][1,2,4]triazolo[3,4-b][1, 3,4] thiadiazole were formed as the result of heterocyclization.

The interaction of heteroaryl-acrylates and alanines with phenylalanine ammonia-lyase from parsley

Acrylic acids and alanines substituted with heteroaryl groups at the β-position were synthesized and spectroscopically characterized (UV, HRMS, 1H NMR, and 13C NMR spectroscopy). The heteroaryl groups were furanyl, thiophenyl, benzofuranyl, and benzothiophenyl and contained the alanyl side chains either at the 2- or 3-positions. While the former are good substrates for phenylalanine ammonia lyase (PAL), the latter compounds are inhibitors. Exceptions are thiophen-3-yl-alanine, a moderate substrate and furan-3-yl-alanine, which is inert. Possible reasons for these exceptions are discussed. Starting from racemic het eroaryl-2-alanines their D-enantiomers were prepared by using a stereodestructive procedure. From the heteroaryl-2- acrylates, the L-enantiomers of the heteroaryl-2-alanines were prepared at high ammonia concentration. These results can be best explained by a Friedel - Crafts-type electrophilic attack at the aromatic part of the substrates as the initial step of the PAL reaction.

Synthesis and some CNS activities of new benzofuranylacryloylpiperazines

A series of novel benzofuranylacryloylpiperazines, which are structurally related to both cinnamamide derivatives and befuraline, have been prepared as their hydrochlorides. Their anticonvulsant and antidepressant activities against seizures induced by el

Syntheses of Furano Compounds: Part XLIV. Syntheses of 2-CarboxybenzoFuran-3-Acetic Acid and 3-CarboxybenzoFuran-2-Acetic Acid

1-Carboxybenzofuran-3-acetic acid and 3-carboxybenzofuran-acetic acid have been synthesised. A new synthesis of benzofuran-3-acetic acid, a plant hormone is reported.